STRINGSTRING
SMD44_07319 SMD44_07319 SMD44_02101 SMD44_02101 pgk pgk tpiA tpiA pgi pgi ppdK ppdK ispG ispG SMD44_03366 SMD44_03366 SMD44_04474 SMD44_04474 SMD44_04476 SMD44_04476 ispH ispH pfkA-3 pfkA-3 glk-4 glk-4 dxr dxr aceE-2 aceE-2 SMD44_03029 SMD44_03029 dxs dxs SMD44_03272 SMD44_03272 aceE aceE eno eno SMD44_08528 SMD44_08528 SMD44_08321 SMD44_08321 ispE ispE eno-2 eno-2 SMD44_04634 SMD44_04634 gpmA gpmA ispD ispD ispF ispF SMD44_02388 SMD44_02388 aceE-3 aceE-3 SMD44_04458 SMD44_04458 SMD44_05846 SMD44_05846 SMD44_04456 SMD44_04456 SMD44_04405 SMD44_04405 dxs-2 dxs-2 ispG-2 ispG-2 pckG pckG SMD44_06441 SMD44_06441 SMD44_02195 SMD44_02195 pfkA-2 pfkA-2 pfkA pfkA SMD44_05981 SMD44_05981
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMD44_07319Unannotated protein. (216 aa)
SMD44_02101Unannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
pgkUnannotated protein; Belongs to the phosphoglycerate kinase family. (403 aa)
tpiAUnannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa)
pgiUnannotated protein; Belongs to the GPI family. (550 aa)
ppdKUnannotated protein; Belongs to the PEP-utilizing enzyme family. (911 aa)
ispGUnannotated protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (384 aa)
SMD44_03366Unannotated protein. (147 aa)
SMD44_04474Unannotated protein. (412 aa)
SMD44_04476Unannotated protein. (491 aa)
ispHUnannotated protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (303 aa)
pfkA-3Unannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa)
glk-4Unannotated protein. (317 aa)
dxrUnannotated protein. (432 aa)
aceE-2Unannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
SMD44_03029Unannotated protein. (294 aa)
dxsUnannotated protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (659 aa)
SMD44_03272Unannotated protein. (476 aa)
aceEUnannotated protein. (775 aa)
enoUnannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
SMD44_08528Unannotated protein. (334 aa)
SMD44_08321Unannotated protein. (335 aa)
ispEUnannotated protein; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (303 aa)
eno-2Unannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
SMD44_04634Unannotated protein; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa)
gpmAUnannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (253 aa)
ispDUnannotated protein; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (266 aa)
ispFUnannotated protein; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (197 aa)
SMD44_02388Unannotated protein. (595 aa)
aceE-3Unannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (897 aa)
SMD44_04458Unannotated protein. (557 aa)
SMD44_05846Unannotated protein. (404 aa)
SMD44_04456Unannotated protein. (380 aa)
SMD44_04405Unannotated protein. (491 aa)
dxs-2Unannotated protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (666 aa)
ispG-2Unannotated protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (388 aa)
pckGUnannotated protein; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (616 aa)
SMD44_06441Unannotated protein; Belongs to the phosphoglycerate mutase family. (219 aa)
SMD44_02195Unannotated protein; Belongs to the pyruvate kinase family. (478 aa)
pfkA-2Unannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
pfkAUnannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
SMD44_05981Unannotated protein; Belongs to the pyruvate kinase family. (476 aa)
Your Current Organism:
Streptomyces alboflavus
NCBI taxonomy Id: 67267
Other names: ATCC 12626, ATCC 23874, Actinomyces alboflavus, BCRC 13664, CBS 613.68, CCRC 13664, CCRC:13664, CIP 104427, DSM 40045, IFO 13196, IMET 42936, ISP 5045, JCM 4615, KCTC 9674, NBRC 13196, NRRL B-2373, NRRL-ISP 5045, S. alboflavus, Streptomyces albiflavus, VKM Ac-972
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