STRINGSTRING
adhE adhE SMD44_01788 SMD44_01788 frmA frmA SMD44_08466 SMD44_08466 eno eno aceE aceE glk glk SMD44_07883 SMD44_07883 korA korA korB korB acsA acsA SMD44_07204 SMD44_07204 aceE-2 aceE-2 SMD44_02556 SMD44_02556 frmA-2 frmA-2 SMD44_08166 SMD44_08166 SMD44_06829 SMD44_06829 ppdK ppdK glk-2 glk-2 SMD44_01403 SMD44_01403 pgi pgi tpiA tpiA pgk pgk SMD44_02101 SMD44_02101 SMD44_04405 SMD44_04405 SMD44_04456 SMD44_04456 SMD44_04457 SMD44_04457 aceE-3 aceE-3 SMD44_02387 SMD44_02387 glk-3 glk-3 gpmA gpmA SMD44_03699 SMD44_03699 frmA-3 frmA-3 SMD44_04839 SMD44_04839 SMD44_04634 SMD44_04634 SMD44_04632 SMD44_04632 eno-2 eno-2 SMD44_05981 SMD44_05981 pfkA pfkA pfkA-2 pfkA-2 yahK yahK SMD44_03590 SMD44_03590 SMD44_02195 SMD44_02195 pckG pckG glk-4 glk-4 pfkA-3 pfkA-3 glpX glpX ppgK ppgK SMD44_02977 SMD44_02977 SMD44_04475 SMD44_04475 SMD44_04474 SMD44_04474 SMD44_05508 SMD44_05508 SMD44_01160 SMD44_01160
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
adhEUnannotated protein; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (896 aa)
SMD44_01788Unannotated protein; Belongs to the aldehyde dehydrogenase family. (467 aa)
frmAUnannotated protein. (361 aa)
SMD44_08466Unannotated protein. (342 aa)
enoUnannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
aceEUnannotated protein. (775 aa)
glkUnannotated protein. (323 aa)
SMD44_07883Unannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (481 aa)
korAUnannotated protein. (644 aa)
korBUnannotated protein. (360 aa)
acsAUnannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa)
SMD44_07204Unannotated protein. (446 aa)
aceE-2Unannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
SMD44_02556Unannotated protein; Belongs to the aldehyde dehydrogenase family. (492 aa)
frmA-2Unannotated protein. (360 aa)
SMD44_08166Unannotated protein; Belongs to the aldehyde dehydrogenase family. (518 aa)
SMD44_06829Unannotated protein. (568 aa)
ppdKUnannotated protein; Belongs to the PEP-utilizing enzyme family. (911 aa)
glk-2Unannotated protein. (385 aa)
SMD44_01403Unannotated protein. (149 aa)
pgiUnannotated protein; Belongs to the GPI family. (550 aa)
tpiAUnannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa)
pgkUnannotated protein; Belongs to the phosphoglycerate kinase family. (403 aa)
SMD44_02101Unannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
SMD44_04405Unannotated protein. (491 aa)
SMD44_04456Unannotated protein. (380 aa)
SMD44_04457Unannotated protein. (334 aa)
aceE-3Unannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (897 aa)
SMD44_02387Unannotated protein. (462 aa)
glk-3Unannotated protein. (321 aa)
gpmAUnannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (253 aa)
SMD44_03699Unannotated protein. (741 aa)
frmA-3Unannotated protein. (349 aa)
SMD44_04839Unannotated protein; Belongs to the aldehyde dehydrogenase family. (485 aa)
SMD44_04634Unannotated protein; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa)
SMD44_04632Unannotated protein. (251 aa)
eno-2Unannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
SMD44_05981Unannotated protein; Belongs to the pyruvate kinase family. (476 aa)
pfkAUnannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
pfkA-2Unannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
yahKUnannotated protein. (350 aa)
SMD44_03590Unannotated protein; Belongs to the aldehyde dehydrogenase family. (516 aa)
SMD44_02195Unannotated protein; Belongs to the pyruvate kinase family. (478 aa)
pckGUnannotated protein; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (616 aa)
glk-4Unannotated protein. (317 aa)
pfkA-3Unannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa)
glpXUnannotated protein. (344 aa)
ppgKUnannotated protein. (250 aa)
SMD44_02977Unannotated protein. (421 aa)
SMD44_04475Unannotated protein. (326 aa)
SMD44_04474Unannotated protein. (412 aa)
SMD44_05508Unannotated protein. (486 aa)
SMD44_01160Unannotated protein. (467 aa)
Your Current Organism:
Streptomyces alboflavus
NCBI taxonomy Id: 67267
Other names: ATCC 12626, ATCC 23874, Actinomyces alboflavus, BCRC 13664, CBS 613.68, CCRC 13664, CCRC:13664, CIP 104427, DSM 40045, IFO 13196, IMET 42936, ISP 5045, JCM 4615, KCTC 9674, NBRC 13196, NRRL B-2373, NRRL-ISP 5045, S. alboflavus, Streptomyces albiflavus, VKM Ac-972
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