STRINGSTRING
yagT yagT yagS yagS yagR yagR SMD44_00228 SMD44_00228 SMD44_00227 SMD44_00227 rdgB rdgB SMD44_05205 SMD44_05205 SMD44_00523 SMD44_00523 dgt dgt SMD44_06844 SMD44_06844 uraH uraH hpxQ hpxQ SMD44_02828 SMD44_02828 guaB guaB gmk gmk relA relA apt apt SMD44_01571 SMD44_01571 purH purH SMD44_02366 SMD44_02366 dgt-2 dgt-2 ppx-gppA ppx-gppA hprT hprT SMD44_07455 SMD44_07455 guaB-2 guaB-2 guaB-3 guaB-3 guaA guaA guaB-4 guaB-4 rdgB-2 rdgB-2 ppx-gppA-2 ppx-gppA-2 SMD44_05803 SMD44_05803 SMD44_05802 SMD44_05802 SMD44_05981 SMD44_05981 SMD44_06016 SMD44_06016 ndk ndk cpdB cpdB SMD44_02195 SMD44_02195 purM purM purF purF purL purL purL-2 purL-2 purL-3 purL-3 purC purC purD purD SMD44_05450 SMD44_05450 SMD44_06435 SMD44_06435 relA-2 relA-2 SMD44_06690 SMD44_06690 ureC ureC ureB ureB ureA ureA purB purB SMD44_03965 SMD44_03965 cysN-2 cysN-2 cysD cysD cysC cysC purE purE purK purK purA purA prs prs SMD44_04356 SMD44_04356 ureC-2 ureC-2 ureAB ureAB add add SMD44_05529 SMD44_05529 punA punA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yagTUnannotated protein. (193 aa)
yagSUnannotated protein. (333 aa)
yagRUnannotated protein. (715 aa)
SMD44_00228Unannotated protein. (340 aa)
SMD44_00227Unannotated protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (722 aa)
rdgBUnannotated protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (200 aa)
SMD44_05205Unannotated protein. (356 aa)
SMD44_00523Unannotated protein. (315 aa)
dgtUnannotated protein; Belongs to the dGTPase family. Type 2 subfamily. (441 aa)
SMD44_06844Unannotated protein; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. (318 aa)
uraHUnannotated protein; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (135 aa)
hpxQUnannotated protein. (170 aa)
SMD44_02828Unannotated protein; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (333 aa)
guaBUnannotated protein. (480 aa)
gmkUnannotated protein; Essential for recycling GMP and indirectly, cGMP. (197 aa)
relAUnannotated protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (863 aa)
aptUnannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa)
SMD44_01571Unannotated protein. (186 aa)
purHUnannotated protein. (527 aa)
SMD44_02366Unannotated protein. (324 aa)
dgt-2Unannotated protein; Belongs to the dGTPase family. Type 2 subfamily. (440 aa)
ppx-gppAUnannotated protein. (316 aa)
hprTUnannotated protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (187 aa)
SMD44_07455Unannotated protein. (336 aa)
guaB-2Unannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (502 aa)
guaB-3Unannotated protein. (374 aa)
guaAUnannotated protein; Catalyzes the synthesis of GMP from XMP. (534 aa)
guaB-4Unannotated protein. (391 aa)
rdgB-2Unannotated protein. (328 aa)
ppx-gppA-2Unannotated protein. (314 aa)
SMD44_05803Unannotated protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (832 aa)
SMD44_05802Unannotated protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (346 aa)
SMD44_05981Unannotated protein; Belongs to the pyruvate kinase family. (476 aa)
SMD44_06016Unannotated protein. (342 aa)
ndkUnannotated protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa)
cpdBUnannotated protein; Belongs to the 5'-nucleotidase family. (613 aa)
SMD44_02195Unannotated protein; Belongs to the pyruvate kinase family. (478 aa)
purMUnannotated protein. (357 aa)
purFUnannotated protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (508 aa)
purLUnannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (749 aa)
purL-2Unannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (227 aa)
purL-3Unannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (87 aa)
purCUnannotated protein; Belongs to the SAICAR synthetase family. (299 aa)
purDUnannotated protein; Belongs to the GARS family. (419 aa)
SMD44_05450Unannotated protein. (229 aa)
SMD44_06435Unannotated protein; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (963 aa)
relA-2Unannotated protein. (715 aa)
SMD44_06690Unannotated protein. (249 aa)
ureCUnannotated protein. (573 aa)
ureBUnannotated protein; Belongs to the urease beta subunit family. (122 aa)
ureAUnannotated protein; Belongs to the urease gamma subunit family. (100 aa)
purBUnannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (494 aa)
SMD44_03965Unannotated protein; Belongs to the 5'-nucleotidase family. (611 aa)
cysN-2Unannotated protein; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (451 aa)
cysDUnannotated protein. (323 aa)
cysCUnannotated protein; Catalyzes the synthesis of activated sulfate. (177 aa)
purEUnannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (180 aa)
purKUnannotated protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (376 aa)
purAUnannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
prsUnannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (328 aa)
SMD44_04356Unannotated protein. (437 aa)
ureC-2Unannotated protein. (560 aa)
ureABUnannotated protein. (232 aa)
addUnannotated protein; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (397 aa)
SMD44_05529Unannotated protein. (451 aa)
punAUnannotated protein; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (274 aa)
Your Current Organism:
Streptomyces alboflavus
NCBI taxonomy Id: 67267
Other names: ATCC 12626, ATCC 23874, Actinomyces alboflavus, BCRC 13664, CBS 613.68, CCRC 13664, CCRC:13664, CIP 104427, DSM 40045, IFO 13196, IMET 42936, ISP 5045, JCM 4615, KCTC 9674, NBRC 13196, NRRL B-2373, NRRL-ISP 5045, S. alboflavus, Streptomyces albiflavus, VKM Ac-972
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