STRINGSTRING
adhE adhE SMD44_01788 SMD44_01788 leuA leuA aceE aceE SMD44_01118 SMD44_01118 SMD44_03272 SMD44_03272 poxB poxB korA korA korB korB acsA acsA SMD44_07223 SMD44_07223 SMD44_00711 SMD44_00711 aceE-2 aceE-2 SMD44_02572 SMD44_02572 SMD44_02556 SMD44_02556 SMD44_08166 SMD44_08166 SMD44_06874 SMD44_06874 SMD44_06829 SMD44_06829 poxB-2 poxB-2 acyP acyP ppdK ppdK leuA-2 leuA-2 SMD44_02833 SMD44_02833 SMD44_01549 SMD44_01549 SMD44_01318 SMD44_01318 SMD44_07273 SMD44_07273 mdh mdh SMD44_04411 SMD44_04411 SMD44_04456 SMD44_04456 SMD44_04457 SMD44_04457 aceE-3 aceE-3 SMD44_02387 SMD44_02387 SMD44_05945 SMD44_05945 SMD44_03699 SMD44_03699 SMD44_04839 SMD44_04839 SMD44_03432 SMD44_03432 SMD44_03569 SMD44_03569 SMD44_05846 SMD44_05846 leuA-3 leuA-3 SMD44_05981 SMD44_05981 ackA ackA pta pta SMD44_03590 SMD44_03590 SMD44_02195 SMD44_02195 pckG pckG ldhA ldhA SMD44_00094 SMD44_00094 fumC fumC SMD44_05634 SMD44_05634 SMD44_04475 SMD44_04475 SMD44_04474 SMD44_04474 ppc ppc leuA-4 leuA-4 bccA-2 bccA-2 SMD44_05508 SMD44_05508 SMD44_01160 SMD44_01160
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
adhEUnannotated protein; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (896 aa)
SMD44_01788Unannotated protein; Belongs to the aldehyde dehydrogenase family. (467 aa)
leuAUnannotated protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (577 aa)
aceEUnannotated protein. (775 aa)
SMD44_01118Unannotated protein. (507 aa)
SMD44_03272Unannotated protein. (476 aa)
poxBUnannotated protein; Belongs to the TPP enzyme family. (607 aa)
korAUnannotated protein. (644 aa)
korBUnannotated protein. (360 aa)
acsAUnannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa)
SMD44_07223Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (385 aa)
SMD44_00711Unannotated protein. (397 aa)
aceE-2Unannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
SMD44_02572Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
SMD44_02556Unannotated protein; Belongs to the aldehyde dehydrogenase family. (492 aa)
SMD44_08166Unannotated protein; Belongs to the aldehyde dehydrogenase family. (518 aa)
SMD44_06874Unannotated protein; Belongs to the malate synthase family. (540 aa)
SMD44_06829Unannotated protein. (568 aa)
poxB-2Unannotated protein; Belongs to the TPP enzyme family. (594 aa)
acyPUnannotated protein. (93 aa)
ppdKUnannotated protein; Belongs to the PEP-utilizing enzyme family. (911 aa)
leuA-2Unannotated protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (574 aa)
SMD44_02833Unannotated protein. (133 aa)
SMD44_01549Unannotated protein. (234 aa)
SMD44_01318Unannotated protein. (137 aa)
SMD44_07273Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
mdhUnannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
SMD44_04411Unannotated protein. (438 aa)
SMD44_04456Unannotated protein. (380 aa)
SMD44_04457Unannotated protein. (334 aa)
aceE-3Unannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (897 aa)
SMD44_02387Unannotated protein. (462 aa)
SMD44_05945Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
SMD44_03699Unannotated protein. (741 aa)
SMD44_04839Unannotated protein; Belongs to the aldehyde dehydrogenase family. (485 aa)
SMD44_03432Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
SMD44_03569Unannotated protein. (751 aa)
SMD44_05846Unannotated protein. (404 aa)
leuA-3Unannotated protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (589 aa)
SMD44_05981Unannotated protein; Belongs to the pyruvate kinase family. (476 aa)
ackAUnannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (403 aa)
ptaUnannotated protein; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (701 aa)
SMD44_03590Unannotated protein; Belongs to the aldehyde dehydrogenase family. (516 aa)
SMD44_02195Unannotated protein; Belongs to the pyruvate kinase family. (478 aa)
pckGUnannotated protein; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (616 aa)
ldhAUnannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (334 aa)
SMD44_00094Unannotated protein. (388 aa)
fumCUnannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (477 aa)
SMD44_05634Unannotated protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (555 aa)
SMD44_04475Unannotated protein. (326 aa)
SMD44_04474Unannotated protein. (412 aa)
ppcUnannotated protein; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (922 aa)
leuA-4Unannotated protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (541 aa)
bccA-2Unannotated protein. (590 aa)
SMD44_05508Unannotated protein. (486 aa)
SMD44_01160Unannotated protein. (467 aa)
Your Current Organism:
Streptomyces alboflavus
NCBI taxonomy Id: 67267
Other names: ATCC 12626, ATCC 23874, Actinomyces alboflavus, BCRC 13664, CBS 613.68, CCRC 13664, CCRC:13664, CIP 104427, DSM 40045, IFO 13196, IMET 42936, ISP 5045, JCM 4615, KCTC 9674, NBRC 13196, NRRL B-2373, NRRL-ISP 5045, S. alboflavus, Streptomyces albiflavus, VKM Ac-972
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