STRINGSTRING
SMD44_01788 SMD44_01788 ilvE ilvE panE panE SMD44_07157 SMD44_07157 panE-2 panE-2 SMD44_03063 SMD44_03063 panE-3 panE-3 SMD44_02556 SMD44_02556 coaD coaD SMD44_06977 SMD44_06977 aguB aguB coaBC coaBC SMD44_01587 SMD44_01587 ilvD ilvD coaX coaX panC panC SMD44_04839 SMD44_04839 ilvE-2 ilvE-2 coaA coaA acpS acpS SMD44_03590 SMD44_03590 coaE coaE SMD44_06147 SMD44_06147 ilvC ilvC SMD44_06124 SMD44_06124 SMD44_06123 SMD44_06123 panB panB panE-4 panE-4 SMD44_05508 SMD44_05508
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMD44_01788Unannotated protein; Belongs to the aldehyde dehydrogenase family. (467 aa)
ilvEUnannotated protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (314 aa)
panEUnannotated protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (334 aa)
SMD44_07157Unannotated protein. (563 aa)
panE-2Unannotated protein. (326 aa)
SMD44_03063Unannotated protein; Belongs to the TPP enzyme family. (561 aa)
panE-3Unannotated protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (326 aa)
SMD44_02556Unannotated protein; Belongs to the aldehyde dehydrogenase family. (492 aa)
coaDUnannotated protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (169 aa)
SMD44_06977Unannotated protein. (467 aa)
aguBUnannotated protein. (280 aa)
coaBCUnannotated protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (416 aa)
SMD44_01587Unannotated protein. (273 aa)
ilvDUnannotated protein; Belongs to the IlvD/Edd family. (617 aa)
coaXUnannotated protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (268 aa)
panCUnannotated protein; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (349 aa)
SMD44_04839Unannotated protein; Belongs to the aldehyde dehydrogenase family. (485 aa)
ilvE-2Unannotated protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (311 aa)
coaAUnannotated protein. (335 aa)
acpSUnannotated protein; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (122 aa)
SMD44_03590Unannotated protein; Belongs to the aldehyde dehydrogenase family. (516 aa)
coaEUnannotated protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (203 aa)
SMD44_06147Unannotated protein. (362 aa)
ilvCUnannotated protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
SMD44_06124Unannotated protein. (180 aa)
SMD44_06123Unannotated protein. (617 aa)
panBUnannotated protein; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (293 aa)
panE-4Unannotated protein. (333 aa)
SMD44_05508Unannotated protein. (486 aa)
Your Current Organism:
Streptomyces alboflavus
NCBI taxonomy Id: 67267
Other names: ATCC 12626, ATCC 23874, Actinomyces alboflavus, BCRC 13664, CBS 613.68, CCRC 13664, CCRC:13664, CIP 104427, DSM 40045, IFO 13196, IMET 42936, ISP 5045, JCM 4615, KCTC 9674, NBRC 13196, NRRL B-2373, NRRL-ISP 5045, S. alboflavus, Streptomyces albiflavus, VKM Ac-972
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