STRINGSTRING
frmA frmA fdoI fdoI SMD44_01758 SMD44_01758 paaH paaH SMD44_01631 SMD44_01631 mmsA mmsA SMD44_08466 SMD44_08466 slcC slcC ccrA ccrA SMD44_00348 SMD44_00348 eno eno aceE aceE SMD44_00220 SMD44_00220 SMD44_00214 SMD44_00214 cysK cysK glk glk SMD44_01087 SMD44_01087 SMD44_03272 SMD44_03272 SMD44_06601 SMD44_06601 serB serB SMD44_04332 SMD44_04332 paaH-2 paaH-2 serA serA crt crt SMD44_07883 SMD44_07883 sdhC sdhC sdhA sdhA sdhB sdhB korA korA korB korB acsA acsA SMD44_07223 SMD44_07223 sucD sucD sucC sucC fdoG fdoG mmsA-2 mmsA-2 SMD44_03036 SMD44_03036 SMD44_00622 SMD44_00622 SMD44_00711 SMD44_00711 aceE-2 aceE-2 eda eda SMD44_02572 SMD44_02572 frmA-2 frmA-2 SMD44_06874 SMD44_06874 katE katE SMD44_06829 SMD44_06829 ppdK ppdK paaH-3 paaH-3 ccrA-2 ccrA-2 ecm ecm glk-2 glk-2 rpe rpe gcvP gcvP SMD44_01266 SMD44_01266 SMD44_01265 SMD44_01265 SMD44_02089 SMD44_02089 tal tal zwf zwf pgl pgl pgi pgi tpiA tpiA pgk pgk SMD44_02101 SMD44_02101 SMD44_07273 SMD44_07273 fadJ fadJ SMD44_07332 SMD44_07332 folD folD mdh mdh glyA glyA SMD44_04405 SMD44_04405 SMD44_04411 SMD44_04411 paaH-4 paaH-4 SMD44_04456 SMD44_04456 SMD44_04457 SMD44_04457 SMD44_07628 SMD44_07628 aceE-3 aceE-3 SMD44_02388 SMD44_02388 SMD44_02387 SMD44_02387 glk-3 glk-3 gpmA gpmA glyA-2 glyA-2 paaH-5 paaH-5 SMD44_05944 SMD44_05944 SMD44_05945 SMD44_05945 frmA-3 frmA-3 serB-2 serB-2 serC serC SMD44_03754 SMD44_03754 SMD44_03750 SMD44_03750 SMD44_07426 SMD44_07426 SMD44_07425 SMD44_07425 SMD44_05320 SMD44_05320 sucC-2 sucC-2 sucD-2 sucD-2 SMD44_04634 SMD44_04634 kdgK-2 kdgK-2 eno-2 eno-2 SMD44_03432 SMD44_03432 SMD44_05846 SMD44_05846 katE-2 katE-2 SMD44_06069 SMD44_06069 gcvH gcvH gcvT gcvT sdhB-2 sdhB-2 sdhA-2 sdhA-2 SMD44_05966 SMD44_05966 SMD44_05981 SMD44_05981 ackA ackA pta pta pfkA pfkA pfkA-2 pfkA-2 SMD44_05553 SMD44_05553 SMD44_02195 SMD44_02195 sdhC-2 sdhC-2 sdhD sdhD sdhA-3 sdhA-3 sdhB-3 sdhB-3 SMD44_06467 SMD44_06467 SMD44_06466 SMD44_06466 serA-2 serA-2 glk-4 glk-4 pfkA-3 pfkA-3 metF metF katE-3 katE-3 fumC fumC SMD44_05634 SMD44_05634 glpX glpX ppgK ppgK rpiB rpiB eda-2 eda-2 SMD44_04475 SMD44_04475 SMD44_04474 SMD44_04474 SMD44_05857 SMD44_05857 prs prs ppc ppc SMD44_05527 SMD44_05527 bccA-2 bccA-2 SMD44_01160 SMD44_01160
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
frmAUnannotated protein. (361 aa)
fdoIUnannotated protein. (194 aa)
SMD44_01758Unannotated protein. (169 aa)
paaHUnannotated protein. (286 aa)
SMD44_01631Unannotated protein; Belongs to the monomeric-type IDH family. (739 aa)
mmsAUnannotated protein. (499 aa)
SMD44_08466Unannotated protein. (342 aa)
slcCUnannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (332 aa)
ccrAUnannotated protein. (448 aa)
SMD44_00348Unannotated protein. (319 aa)
enoUnannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
aceEUnannotated protein. (775 aa)
SMD44_00220Unannotated protein. (428 aa)
SMD44_00214Unannotated protein; Belongs to the citrate synthase family. (381 aa)
cysKUnannotated protein. (380 aa)
glkUnannotated protein. (323 aa)
SMD44_01087Unannotated protein. (388 aa)
SMD44_03272Unannotated protein. (476 aa)
SMD44_06601Unannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
serBUnannotated protein. (223 aa)
SMD44_04332Unannotated protein. (294 aa)
paaH-2Unannotated protein. (289 aa)
serAUnannotated protein. (360 aa)
crtUnannotated protein. (278 aa)
SMD44_07883Unannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (481 aa)
sdhCUnannotated protein. (235 aa)
sdhAUnannotated protein. (649 aa)
sdhBUnannotated protein. (248 aa)
korAUnannotated protein. (644 aa)
korBUnannotated protein. (360 aa)
acsAUnannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa)
SMD44_07223Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (385 aa)
sucDUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
sucCUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (379 aa)
fdoGUnannotated protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (663 aa)
mmsA-2Unannotated protein. (509 aa)
SMD44_03036Unannotated protein; Belongs to the citrate synthase family. (432 aa)
SMD44_00622Unannotated protein. (381 aa)
SMD44_00711Unannotated protein. (397 aa)
aceE-2Unannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
edaUnannotated protein. (207 aa)
SMD44_02572Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
frmA-2Unannotated protein. (360 aa)
SMD44_06874Unannotated protein; Belongs to the malate synthase family. (540 aa)
katEUnannotated protein; Belongs to the catalase family. (488 aa)
SMD44_06829Unannotated protein. (568 aa)
ppdKUnannotated protein; Belongs to the PEP-utilizing enzyme family. (911 aa)
paaH-3Unannotated protein. (593 aa)
ccrA-2Unannotated protein. (445 aa)
ecmUnannotated protein. (683 aa)
glk-2Unannotated protein. (385 aa)
rpeUnannotated protein; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
gcvPUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (962 aa)
SMD44_01266Unannotated protein. (744 aa)
SMD44_01265Unannotated protein. (617 aa)
SMD44_02089Unannotated protein; Belongs to the transketolase family. (702 aa)
talUnannotated protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (372 aa)
zwfUnannotated protein; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (507 aa)
pglUnannotated protein; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (266 aa)
pgiUnannotated protein; Belongs to the GPI family. (550 aa)
tpiAUnannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa)
pgkUnannotated protein; Belongs to the phosphoglycerate kinase family. (403 aa)
SMD44_02101Unannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
SMD44_07273Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
fadJUnannotated protein. (730 aa)
SMD44_07332Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (417 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
mdhUnannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
SMD44_04405Unannotated protein. (491 aa)
SMD44_04411Unannotated protein. (438 aa)
paaH-4Unannotated protein. (504 aa)
SMD44_04456Unannotated protein. (380 aa)
SMD44_04457Unannotated protein. (334 aa)
SMD44_07628Unannotated protein; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (479 aa)
aceE-3Unannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (897 aa)
SMD44_02388Unannotated protein. (595 aa)
SMD44_02387Unannotated protein. (462 aa)
glk-3Unannotated protein. (321 aa)
gpmAUnannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (253 aa)
glyA-2Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (432 aa)
paaH-5Unannotated protein. (282 aa)
SMD44_05944Unannotated protein. (146 aa)
SMD44_05945Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
frmA-3Unannotated protein. (349 aa)
serB-2Unannotated protein. (418 aa)
serCUnannotated protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
SMD44_03754Unannotated protein. (624 aa)
SMD44_03750Unannotated protein; Belongs to the citrate synthase family. (366 aa)
SMD44_07426Unannotated protein. (233 aa)
SMD44_07425Unannotated protein. (298 aa)
SMD44_05320Unannotated protein. (138 aa)
sucC-2Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
sucD-2Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
SMD44_04634Unannotated protein; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa)
kdgK-2Unannotated protein. (364 aa)
eno-2Unannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
SMD44_03432Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
SMD44_05846Unannotated protein. (404 aa)
katE-2Unannotated protein; Belongs to the catalase family. (489 aa)
SMD44_06069Unannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (456 aa)
gcvHUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
gcvTUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. (374 aa)
sdhB-2Unannotated protein. (278 aa)
sdhA-2Unannotated protein. (647 aa)
SMD44_05966Unannotated protein. (566 aa)
SMD44_05981Unannotated protein; Belongs to the pyruvate kinase family. (476 aa)
ackAUnannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (403 aa)
ptaUnannotated protein; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (701 aa)
pfkAUnannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
pfkA-2Unannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
SMD44_05553Unannotated protein. (420 aa)
SMD44_02195Unannotated protein; Belongs to the pyruvate kinase family. (478 aa)
sdhC-2Unannotated protein. (126 aa)
sdhDUnannotated protein. (164 aa)
sdhA-3Unannotated protein. (584 aa)
sdhB-3Unannotated protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (253 aa)
SMD44_06467Unannotated protein; Belongs to the citrate synthase family. (395 aa)
SMD44_06466Unannotated protein. (448 aa)
serA-2Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (534 aa)
glk-4Unannotated protein. (317 aa)
pfkA-3Unannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa)
metFUnannotated protein; Belongs to the methylenetetrahydrofolate reductase family. (288 aa)
katE-3Unannotated protein; Belongs to the catalase family. (481 aa)
fumCUnannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (477 aa)
SMD44_05634Unannotated protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (555 aa)
glpXUnannotated protein. (344 aa)
ppgKUnannotated protein. (250 aa)
rpiBUnannotated protein. (162 aa)
eda-2Unannotated protein. (211 aa)
SMD44_04475Unannotated protein. (326 aa)
SMD44_04474Unannotated protein. (412 aa)
SMD44_05857Unannotated protein. (1270 aa)
prsUnannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (328 aa)
ppcUnannotated protein; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (922 aa)
SMD44_05527Unannotated protein. (539 aa)
bccA-2Unannotated protein. (590 aa)
SMD44_01160Unannotated protein. (467 aa)
Your Current Organism:
Streptomyces alboflavus
NCBI taxonomy Id: 67267
Other names: ATCC 12626, ATCC 23874, Actinomyces alboflavus, BCRC 13664, CBS 613.68, CCRC 13664, CCRC:13664, CIP 104427, DSM 40045, IFO 13196, IMET 42936, ISP 5045, JCM 4615, KCTC 9674, NBRC 13196, NRRL B-2373, NRRL-ISP 5045, S. alboflavus, Streptomyces albiflavus, VKM Ac-972
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