Your Input: | |
| | aroH | Unannotated protein. (120 aa) |
| | tyrA2 | Unannotated protein. (361 aa) |
| | metH | Unannotated protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1182 aa) |
| | glnA | Unannotated protein; Belongs to the glutamine synthetase family. (454 aa) |
| | SMD44_01631 | Unannotated protein; Belongs to the monomeric-type IDH family. (739 aa) |
| | argC | Unannotated protein; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (342 aa) |
| | argJ | Unannotated protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (383 aa) |
| | argB | Unannotated protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (302 aa) |
| | argD | Unannotated protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (408 aa) |
| | argG | Unannotated protein; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (404 aa) |
| | argH | Unannotated protein. (476 aa) |
| | pheC | Unannotated protein. (272 aa) |
| | ilvE | Unannotated protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (314 aa) |
| | slcC | Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (332 aa) |
| | SMD44_00481 | Unannotated protein. (267 aa) |
| | eno | Unannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | leuA | Unannotated protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (577 aa) |
| | metE | Unannotated protein; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (772 aa) |
| | SMD44_00214 | Unannotated protein; Belongs to the citrate synthase family. (381 aa) |
| | cysK | Unannotated protein. (380 aa) |
| | ltaE | Unannotated protein. (356 aa) |
| | SMD44_06586 | Unannotated protein; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (336 aa) |
| | SMD44_06601 | Unannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa) |
| | pheA2 | Unannotated protein. (311 aa) |
| | hisC | Unannotated protein; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa) |
| | SMD44_04283 | Unannotated protein. (410 aa) |
| | serB | Unannotated protein. (223 aa) |
| | asnB | Unannotated protein. (645 aa) |
| | serA | Unannotated protein. (360 aa) |
| | SMD44_07883 | Unannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (481 aa) |
| | SMD44_05207 | Unannotated protein. (450 aa) |
| | SMD44_07157 | Unannotated protein. (563 aa) |
| | thrC | Unannotated protein. (408 aa) |
| | SMD44_03036 | Unannotated protein; Belongs to the citrate synthase family. (432 aa) |
| | SMD44_03063 | Unannotated protein; Belongs to the TPP enzyme family. (561 aa) |
| | SMD44_03130 | Unannotated protein; Belongs to the class-II DAHP synthase family. (457 aa) |
| | trpE | Unannotated protein. (507 aa) |
| | trpG | Unannotated protein. (202 aa) |
| | trpD | Unannotated protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (354 aa) |
| | pheA1 | Unannotated protein. (202 aa) |
| | hisC-2 | Unannotated protein; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (365 aa) |
| | aroA | Unannotated protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (449 aa) |
| | alaA | Unannotated protein. (403 aa) |
| | leuC | Unannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa) |
| | leuD | Unannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa) |
| | dapA-2 | Unannotated protein; Belongs to the DapA family. (310 aa) |
| | leuA-2 | Unannotated protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (574 aa) |
| | SMD44_07046 | Unannotated protein; Belongs to the arginase family. (298 aa) |
| | hisG | Unannotated protein; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa) |
| | hisE | Unannotated protein. (90 aa) |
| | rpe | Unannotated protein; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa) |
| | metK | Unannotated protein; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa) |
| | aroB | Unannotated protein; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (363 aa) |
| | aroK | Unannotated protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (179 aa) |
| | aroC | Unannotated protein; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa) |
| | aroE | Unannotated protein; Belongs to the shikimate dehydrogenase family. (276 aa) |
| | SMD44_01587 | Unannotated protein. (273 aa) |
| | dapA-3 | Unannotated protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (322 aa) |
| | dapD | Unannotated protein; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (332 aa) |
| | SMD44_02089 | Unannotated protein; Belongs to the transketolase family. (702 aa) |
| | tal | Unannotated protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (372 aa) |
| | tpiA | Unannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa) |
| | pgk | Unannotated protein; Belongs to the phosphoglycerate kinase family. (403 aa) |
| | SMD44_02101 | Unannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa) |
| | aroQ | Unannotated protein; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (153 aa) |
| | gltD | Unannotated protein. (496 aa) |
| | glyA | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa) |
| | SMD44_04402 | Unannotated protein. (410 aa) |
| | SMD44_04405 | Unannotated protein. (491 aa) |
| | glnA-2 | Unannotated protein. (345 aa) |
| | glnA-3 | Unannotated protein. (469 aa) |
| | trpD-2 | Unannotated protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (354 aa) |
| | gpmA | Unannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (253 aa) |
| | lysA | Unannotated protein; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa) |
| | SMD44_05899 | Unannotated protein. (429 aa) |
| | thrC-2 | Unannotated protein; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa) |
| | thrB1 | Unannotated protein; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (305 aa) |
| | glyA-2 | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (432 aa) |
| | thrC-3 | Unannotated protein; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (360 aa) |
| | serB-2 | Unannotated protein. (418 aa) |
| | serC | Unannotated protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa) |
| | SMD44_03750 | Unannotated protein; Belongs to the citrate synthase family. (366 aa) |
| | ilvD | Unannotated protein; Belongs to the IlvD/Edd family. (617 aa) |
| | argA | Unannotated protein; Belongs to the acetyltransferase family. (197 aa) |
| | SMD44_07509 | Unannotated protein. (354 aa) |
| | argD-2 | Unannotated protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (415 aa) |
| | argB-2 | Unannotated protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (303 aa) |
| | argJ-2 | Unannotated protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (384 aa) |
| | ilvE-2 | Unannotated protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (311 aa) |
| | SMD44_07426 | Unannotated protein. (233 aa) |
| | SMD44_07425 | Unannotated protein. (298 aa) |
| | pheA1-2 | Unannotated protein. (100 aa) |
| | patB | Unannotated protein. (542 aa) |
| | SMD44_04634 | Unannotated protein; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa) |
| | dapC | Unannotated protein. (417 aa) |
| | eno-2 | Unannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa) |
| | SMD44_03430 | Unannotated protein. (463 aa) |
| | lysA-2 | Unannotated protein. (475 aa) |
| | aroA-2 | Unannotated protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (438 aa) |
| | hisN | Unannotated protein. (266 aa) |
| | leuA-3 | Unannotated protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (589 aa) |
| | SMD44_06069 | Unannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (456 aa) |
| | SMD44_05695 | Unannotated protein. (305 aa) |
| | dapE | Unannotated protein. (373 aa) |
| | SMD44_05981 | Unannotated protein; Belongs to the pyruvate kinase family. (476 aa) |
| | pfkA | Unannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa) |
| | metK-2 | Unannotated protein; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (387 aa) |
| | trpC | Unannotated protein; Belongs to the TrpC family. (269 aa) |
| | trpE-2 | Unannotated protein; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (507 aa) |
| | hisI | Unannotated protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (127 aa) |
| | hisF | Unannotated protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa) |
| | trpF | Unannotated protein; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (242 aa) |
| | hisH | Unannotated protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa) |
| | hisB | Unannotated protein. (197 aa) |
| | hisC-3 | Unannotated protein; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (379 aa) |
| | hisD | Unannotated protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (440 aa) |
| | proA | Unannotated protein; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (427 aa) |
| | proB | Unannotated protein; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (381 aa) |
| | pfkA-2 | Unannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa) |
| | asnB-2 | Unannotated protein. (613 aa) |
| | SMD44_05553 | Unannotated protein. (420 aa) |
| | metB | Unannotated protein. (384 aa) |
| | SMD44_02195 | Unannotated protein; Belongs to the pyruvate kinase family. (478 aa) |
| | SMD44_06467 | Unannotated protein; Belongs to the citrate synthase family. (395 aa) |
| | SMD44_06466 | Unannotated protein. (448 aa) |
| | dapF | Unannotated protein; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (297 aa) |
| | SMD44_06147 | Unannotated protein. (362 aa) |
| | leuB | Unannotated protein. (346 aa) |
| | serA-2 | Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (534 aa) |
| | ilvC | Unannotated protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa) |
| | SMD44_06124 | Unannotated protein. (180 aa) |
| | SMD44_06123 | Unannotated protein. (617 aa) |
| | alaA-2 | Unannotated protein. (403 aa) |
| | pfkA-3 | Unannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa) |
| | SMD44_02321 | Unannotated protein; Belongs to the class-II DAHP synthase family. (450 aa) |
| | lysA-3 | Unannotated protein; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (456 aa) |
| | dapA-4 | Unannotated protein; Belongs to the DapA family. (337 aa) |
| | SMD44_02014 | Unannotated protein; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (423 aa) |
| | dapB | Unannotated protein; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (250 aa) |
| | dapA-5 | Unannotated protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa) |
| | rpiB | Unannotated protein. (162 aa) |
| | asd | Unannotated protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa) |
| | thrC-4 | Unannotated protein. (432 aa) |
| | glnA-4 | Unannotated protein; Belongs to the glutamine synthetase family. (453 aa) |
| | gltD-2 | Unannotated protein. (486 aa) |
| | gltB | Unannotated protein. (1524 aa) |
| | trpA | Unannotated protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (271 aa) |
| | trpB | Unannotated protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (428 aa) |
| | SMD44_06753 | Unannotated protein. (305 aa) |
| | tyrA1 | Unannotated protein. (118 aa) |
| | asd-2 | Unannotated protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (353 aa) |
| | lysC | Unannotated protein; Belongs to the aspartokinase family. (423 aa) |
| | prs | Unannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (328 aa) |
| | leuA-4 | Unannotated protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (541 aa) |
