STRINGSTRING
EQU24_13800 EQU24_13800 EQU24_13675 EQU24_13675 leuB leuB EQU24_12075 EQU24_12075 lpdA lpdA odhB odhB EQU24_11655 EQU24_11655 EQU24_11515 EQU24_11515 EQU24_11510 EQU24_11510 ilvD ilvD gcvH gcvH EQU24_08475 EQU24_08475 EQU24_08335 EQU24_08335 oadG oadG ilvE ilvE EQU24_06980 EQU24_06980 EQU24_06975 EQU24_06975 sdhD sdhD sdhC sdhC EQU24_06435 EQU24_06435 gltA gltA aceE aceE aceF aceF lpdA-3 lpdA-3 EQU24_06025 EQU24_06025 acnB acnB EQU24_06010 EQU24_06010 EQU24_05850 EQU24_05850 oadA oadA EQU24_04695 EQU24_04695 sucD sucD sucC sucC mdh mdh sucD-2 sucD-2 sucC-2 sucC-2 leuA leuA ilvC ilvC ilvN ilvN EQU24_04060 EQU24_04060 fumC fumC EQU24_01475 EQU24_01475 EQU24_01470 EQU24_01470 EQU24_01465 EQU24_01465 fdhD-2 fdhD-2 EQU24_01455 EQU24_01455 EQU24_21320 EQU24_21320 EQU24_20925 EQU24_20925 EQU24_20920 EQU24_20920 EQU24_19925 EQU24_19925 acnA acnA EQU24_19220 EQU24_19220 EQU24_19175 EQU24_19175 oadA-2 oadA-2 leuC leuC leuD leuD gcvP gcvP gcvT gcvT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EQU24_13800Unannotated protein; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (803 aa)
EQU24_13675Unannotated protein. (635 aa)
leuBUnannotated protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (368 aa)
EQU24_12075Unannotated protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (514 aa)
lpdAUnannotated protein. (478 aa)
odhBUnannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (415 aa)
EQU24_11655Unannotated protein. (941 aa)
EQU24_11515Unannotated protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (924 aa)
EQU24_11510Unannotated protein. (568 aa)
ilvDUnannotated protein; Belongs to the IlvD/Edd family. (565 aa)
gcvHUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa)
EQU24_08475Unannotated protein. (409 aa)
EQU24_08335Unannotated protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
oadGUnannotated protein; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation. (87 aa)
ilvEUnannotated protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (306 aa)
EQU24_06980Unannotated protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (261 aa)
EQU24_06975Unannotated protein; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (594 aa)
sdhDUnannotated protein. (126 aa)
sdhCUnannotated protein. (126 aa)
EQU24_06435Unannotated protein; Belongs to the PEP-utilizing enzyme family. (916 aa)
gltAUnannotated protein; Belongs to the citrate synthase family. (432 aa)
aceEUnannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (892 aa)
aceFUnannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (434 aa)
lpdA-3Unannotated protein. (479 aa)
EQU24_06025Unannotated protein. (336 aa)
acnBUnannotated protein; Belongs to the aconitase/IPM isomerase family. (856 aa)
EQU24_06010Unannotated protein; Belongs to the citrate synthase family. (435 aa)
EQU24_05850Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (472 aa)
oadAUnannotated protein. (608 aa)
EQU24_04695Unannotated protein. (563 aa)
sucDUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)
sucCUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
mdhUnannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (327 aa)
sucD-2Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)
sucC-2Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
leuAUnannotated protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (514 aa)
ilvCUnannotated protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
ilvNUnannotated protein. (163 aa)
EQU24_04060Unannotated protein. (593 aa)
fumCUnannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
EQU24_01475Unannotated protein. (158 aa)
EQU24_01470Unannotated protein. (517 aa)
EQU24_01465Unannotated protein. (951 aa)
fdhD-2Unannotated protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (285 aa)
EQU24_01455Unannotated protein. (70 aa)
EQU24_21320Unannotated protein; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (409 aa)
EQU24_20925Unannotated protein. (281 aa)
EQU24_20920Unannotated protein. (581 aa)
EQU24_19925Unannotated protein. (1619 aa)
acnAUnannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (899 aa)
EQU24_19220Unannotated protein; Belongs to the LDH/MDH superfamily. (314 aa)
EQU24_19175Unannotated protein; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the GcdB/MmdB/OadB family. (375 aa)
oadA-2Unannotated protein. (594 aa)
leuCUnannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa)
leuDUnannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (210 aa)
gcvPUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (964 aa)
gcvTUnannotated protein. (374 aa)
Your Current Organism:
Methylomicrobium buryatense
NCBI taxonomy Id: 675511
Other names: M. buryatense 5G, Methylomicrobium buryatense 5G, Methylomicrobium buryatense str. 5G, Methylomicrobium buryatense strain 5G
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