STRINGSTRING
mdh mdh EEX37924.1 EEX37924.1 EEX37872.1 EEX37872.1 grcA grcA EEX37744.1 EEX37744.1 accD-2 accD-2 EEX37565.1 EEX37565.1 EEX37476.1 EEX37476.1 accD accD EEX37386.1 EEX37386.1 ackA ackA maeA maeA EEX37255.1 EEX37255.1 EEX37239.1 EEX37239.1 EEX37238.1 EEX37238.1 EEX37205.1 EEX37205.1 EEX37126.1 EEX37126.1 EEX36844.1 EEX36844.1 EEX36822.1 EEX36822.1 EEX36753.1 EEX36753.1 gloB gloB accA accA ppc ppc EEX38119.1 EEX38119.1 EEX38118.1 EEX38118.1 frdC frdC frdD frdD EEX38096.1 EEX38096.1 pckA pckA leuA leuA EEX38372.1 EEX38372.1 EEX38371.1 EEX38371.1 EEX38370.1 EEX38370.1 fumC fumC EEX35846.1 EEX35846.1 EEX35847.1 EEX35847.1 EEX36167.1 EEX36167.1 EEX36266.1 EEX36266.1 EEX36323.1 EEX36323.1 lldD lldD EEX36402.1 EEX36402.1 ackA-2 ackA-2 EEX36505.1 EEX36505.1 EEX36510.1 EEX36510.1 acsA acsA EEX35707.1 EEX35707.1 EEX35708.1 EEX35708.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (310 aa)
EEX37924.1Pyruvate kinase; Belongs to the pyruvate kinase family. (470 aa)
EEX37872.1Oxaloacetate decarboxylase beta chain; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the GcdB/MmdB/OadB family. (376 aa)
grcAAutonomous glycyl radical cofactor; Acts as a radical domain for damaged PFL and possibly other radical proteins. (125 aa)
EEX37744.1Malate synthase; Belongs to the malate synthase family. (545 aa)
accD-2Acetyl-coenzyme A carboxyl transferase beta chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (254 aa)
EEX37565.1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (138 aa)
EEX37476.1Pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa)
accDAcetyl-coenzyme A carboxyl transferase beta chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (288 aa)
EEX37386.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (714 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
maeANAD-dependent malic enzyme. (562 aa)
EEX37255.1Hydroxyacylglutathione hydrolase. (218 aa)
EEX37239.1Fumarate hydratase class I. (163 aa)
EEX37238.1Fumarate hydratase class I aerobic. (319 aa)
EEX37205.1Phosphoenolpyruvate synthase. (296 aa)
EEX37126.1Zn-dependent hydrolase. (256 aa)
EEX36844.1Pyruvate formate-lyase. (758 aa)
EEX36822.1Alcohol dehydrogenase; Most likely function alternative not yet resolved; acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (890 aa)
EEX36753.1Pyruvate-flavodoxin oxidoreductase. (1093 aa)
gloBHydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (252 aa)
accAAcetyl-coenzyme A carboxyl transferase alpha chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (877 aa)
EEX38119.1Succinate dehydrogenase flavoprotein subunit. (603 aa)
EEX38118.1Succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (252 aa)
frdCFumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (127 aa)
frdDFumarate reductase subunit D; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (120 aa)
EEX38096.1NADP-dependent malic enzyme. (428 aa)
pckAPhosphoenolpyruvate carboxykinase [ATP]; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (539 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (516 aa)
EEX38372.1Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (886 aa)
EEX38371.1Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (628 aa)
EEX38370.1Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. (475 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (456 aa)
EEX35846.1Hypothetical protein. (51 aa)
EEX35847.1Glyoxalase family protein. (119 aa)
EEX36167.1Metallo-beta-lactamase family protein; Similar to PA00057. (287 aa)
EEX36266.1Mannitol operon repressor. (176 aa)
EEX36323.1D-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (332 aa)
lldDL-lactate dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (378 aa)
EEX36402.1Malate synthase-related protein. (192 aa)
ackA-2Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
EEX36505.1Glyoxalase family protein. (119 aa)
EEX36510.1Glyoxalase family protein. (137 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (648 aa)
EEX35707.1acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (151 aa)
EEX35708.1Biotin carboxylase of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
Your Current Organism:
Vibrio metschnikovii
NCBI taxonomy Id: 675813
Other names: V. metschnikovii CIP 69.14, Vibrio metschnikovii CIP 69.14, Vibrio metschnikovii str. CIP 69.14, Vibrio metschnikovii strain CIP 69.14
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