STRINGSTRING
EEX38530.1 EEX38530.1 EEX38354.1 EEX38354.1 EEX38370.1 EEX38370.1 EEX38371.1 EEX38371.1 EEX38372.1 EEX38372.1 eno eno EEX38424.1 EEX38424.1 rpiA rpiA EEX38434.1 EEX38434.1 pckA pckA edd edd EEX38056.1 EEX38056.1 EEX38058.1 EEX38058.1 EEX38077.1 EEX38077.1 pfkA pfkA EEX38090.1 EEX38090.1 EEX38092.1 EEX38092.1 EEX38096.1 EEX38096.1 tpiA tpiA frdD frdD frdC frdC EEX38118.1 EEX38118.1 EEX38119.1 EEX38119.1 EEX38124.1 EEX38124.1 ppc ppc EEX38142.1 EEX38142.1 EEX38151.1 EEX38151.1 fbp fbp EEX38247.1 EEX38247.1 accA accA prs prs EEX36641.1 EEX36641.1 EEX36652.1 EEX36652.1 EEX36698.1 EEX36698.1 EEX36699.1 EEX36699.1 EEX36700.1 EEX36700.1 EEX36701.1 EEX36701.1 EEX36702.1 EEX36702.1 sucC sucC sucD sucD EEX36753.1 EEX36753.1 EEX36761.1 EEX36761.1 fadJ fadJ EEX36929.1 EEX36929.1 fabV fabV EEX36939.1 EEX36939.1 serC serC EEX36979.1 EEX36979.1 EEX37164.1 EEX37164.1 EEX37167.1 EEX37167.1 EEX37168.1 EEX37168.1 EEX37169.1 EEX37169.1 EEX37205.1 EEX37205.1 EEX37238.1 EEX37238.1 EEX37239.1 EEX37239.1 EEX37241.1 EEX37241.1 EEX37297.1 EEX37297.1 maeA maeA ackA ackA EEX37386.1 EEX37386.1 EEX37423.1 EEX37423.1 EEX37425.1 EEX37425.1 EEX37426.1 EEX37426.1 EEX37430.1 EEX37430.1 EEX37447.1 EEX37447.1 accD accD EEX37476.1 EEX37476.1 EEX37539.1 EEX37539.1 folD folD rnfC rnfC accD-2 accD-2 EEX37598.1 EEX37598.1 glyA glyA EEX37662.1 EEX37662.1 EEX37663.1 EEX37663.1 EEX37687.1 EEX37687.1 fumC fumC EEX37743.1 EEX37743.1 EEX37744.1 EEX37744.1 EEX37793.1 EEX37793.1 EEX37905.1 EEX37905.1 EEX37924.1 EEX37924.1 EEX37930.1 EEX37930.1 pgk pgk EEX37935.1 EEX37935.1 mdh mdh EEX38004.1 EEX38004.1 pgi pgi EEX35898.1 EEX35898.1 EEX35903.1 EEX35903.1 fabV-2 fabV-2 EEX36023.1 EEX36023.1 gcvH gcvH gcvP gcvP fhs fhs tal tal EEX36037.1 EEX36037.1 EEX36126.1 EEX36126.1 EEX36130.1 EEX36130.1 EEX36131.1 EEX36131.1 zwf zwf pgl pgl EEX36164.1 EEX36164.1 EEX36325.1 EEX36325.1 EEX36402.1 EEX36402.1 ackA-2 ackA-2 EEX36437.1 EEX36437.1 EEX36459.1 EEX36459.1 acsA acsA EEX35707.1 EEX35707.1 EEX35708.1 EEX35708.1 EEX35819.1 EEX35819.1 fadB fadB ilvA ilvA gpmI gpmI
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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EEX38530.1GCN5-related N-acetyltransferase. (135 aa)
EEX38354.1Aconitate hydratase 2; Enzyme with broad specificity; 2-methylisocitrate dehydratase; Belongs to the aconitase/IPM isomerase family. (865 aa)
EEX38370.1Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. (475 aa)
EEX38371.1Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (628 aa)
EEX38372.1Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (886 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (433 aa)
EEX38424.1Hypothetical protein. (86 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (218 aa)
EEX38434.1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (409 aa)
pckAPhosphoenolpyruvate carboxykinase [ATP]; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (539 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (600 aa)
EEX38056.1Gluconokinase. (171 aa)
EEX38058.14-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase. (202 aa)
EEX38077.1Carbamate kinase; Belongs to the carbamate kinase family. (304 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa)
EEX38090.1Fructose-1,6-bisphosphatase GlpX type. (335 aa)
EEX38092.15,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (297 aa)
EEX38096.1NADP-dependent malic enzyme. (428 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (257 aa)
frdDFumarate reductase subunit D; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (120 aa)
frdCFumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (127 aa)
EEX38118.1Succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (252 aa)
EEX38119.1Succinate dehydrogenase flavoprotein subunit. (603 aa)
EEX38124.1Serine acetyltransferase. (273 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (877 aa)
EEX38142.1Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (226 aa)
EEX38151.1Phosphoribulokinase. (289 aa)
fbpFructose-1,6-bisphosphatase type I; Belongs to the FBPase class 1 family. (337 aa)
EEX38247.1Hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa)
accAAcetyl-coenzyme A carboxyl transferase alpha chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (314 aa)
EEX36641.1Arsenate reductase. (116 aa)
EEX36652.1A glutathione-dependent thiol reductase; Belongs to the ArsC family. (120 aa)
EEX36698.1Citrate synthase (si); Belongs to the citrate synthase family. (429 aa)
EEX36699.1Succinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
EEX36700.1Succinate dehydrogenase iron-sulfur protein. (236 aa)
EEX36701.12-oxoglutarate dehydrogenase E1 component. (936 aa)
EEX36702.1Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (402 aa)
sucCsuccinyl-CoA ligase [ADP-forming] beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA ligase [ADP-forming] alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
EEX36753.1Pyruvate-flavodoxin oxidoreductase. (1093 aa)
EEX36761.1NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
fadJEnoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (708 aa)
EEX36929.1NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
fabVShort-chain alcohol dehydrogenase family; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (400 aa)
EEX36939.1Glucose repressor HexR for Entner-Doudoroff pathway RpiR family. (284 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (364 aa)
EEX36979.1Isocitrate dehydrogenase [NADP]; Most likely function alternative not yet resolved; monomeric isocitrate dehydrogenase [NADP]; Belongs to the monomeric-type IDH family. (742 aa)
EEX37164.1Iron-sulfur cluster-binding protein. (553 aa)
EEX37167.1Formate dehydrogenase-O major subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (950 aa)
EEX37168.1Formate dehydrogenase-O iron-sulfur subunit; Most likely function alternative not yet resolved; putative formate dehydrogenase iron-sulfur subunit. (202 aa)
EEX37169.1Formate dehydrogenase -O gamma subunit. (352 aa)
EEX37205.1Phosphoenolpyruvate synthase. (296 aa)
EEX37238.1Fumarate hydratase class I aerobic. (319 aa)
EEX37239.1Fumarate hydratase class I. (163 aa)
EEX37241.1L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (431 aa)
EEX37297.1Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (75 aa)
maeANAD-dependent malic enzyme. (562 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
EEX37386.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (714 aa)
EEX37423.1Hypothetical protein. (348 aa)
EEX37425.12-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase. (209 aa)
EEX37426.12-dehydro-3-deoxygluconate kinase. (324 aa)
EEX37430.1Transcriptional regulator. (287 aa)
EEX37447.1Cysteine synthase B. (355 aa)
accDAcetyl-coenzyme A carboxyl transferase beta chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (288 aa)
EEX37476.1Pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa)
EEX37539.1L-serine dehydratase. (499 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa)
rnfCElectron transport complex protein RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (734 aa)
accD-2Acetyl-coenzyme A carboxyl transferase beta chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (254 aa)
EEX37598.1Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa)
EEX37662.1S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (381 aa)
EEX37663.1S-formylglutathione hydrolase. (102 aa)
EEX37687.1acetoacetyl-CoA reductase. (246 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (456 aa)
EEX37743.1Isocitrate lyase. (436 aa)
EEX37744.1Malate synthase; Belongs to the malate synthase family. (545 aa)
EEX37793.1Phosphoserine phosphatase. (326 aa)
EEX37905.1Anaerobic dimethyl sulfoxide reductase chain B. (123 aa)
EEX37924.1Pyruvate kinase; Belongs to the pyruvate kinase family. (470 aa)
EEX37930.1Fructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (358 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (362 aa)
EEX37935.1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (310 aa)
EEX38004.1Serine--pyruvate aminotransferase/L-alanine:glyoxylate aminotransferase. (375 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (550 aa)
EEX35898.1Methylmalonate-semialdehyde dehydrogenase [inositol]. (503 aa)
EEX35903.1Predicted transcriptional regulator of the myo-inositol catabolism operon. (278 aa)
fabV-2Uncharacterized paraquat-inducible protein B; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (398 aa)
EEX36023.1Aminomethyltransferase (glycine cleavage system T protein). (377 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
gcvPGlycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (926 aa)
fhsFormate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (579 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (319 aa)
EEX36037.1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (663 aa)
EEX36126.1Ribose 5-phosphate isomerase. (211 aa)
EEX36130.12-dehydro-3-deoxygluconate kinase. (310 aa)
EEX36131.14-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase. (207 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (477 aa)
pgl6-phosphogluconolactonase eukaryotic type; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (238 aa)
EEX36164.16-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (482 aa)
EEX36325.1Hypothetical protein. (102 aa)
EEX36402.1Malate synthase-related protein. (192 aa)
ackA-2Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
EEX36437.1NADPH-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (477 aa)
EEX36459.1Acyl dehydratase. (202 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (648 aa)
EEX35707.1acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (151 aa)
EEX35708.1Biotin carboxylase of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
EEX35819.1Transcriptional regulator RpiR family. (282 aa)
fadBEnoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (723 aa)
ilvAThreonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (494 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa)
Your Current Organism:
Vibrio metschnikovii
NCBI taxonomy Id: 675813
Other names: V. metschnikovii CIP 69.14, Vibrio metschnikovii CIP 69.14, Vibrio metschnikovii str. CIP 69.14, Vibrio metschnikovii strain CIP 69.14
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