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flhB flhB flhA flhA lolB lolB ARD38179.1 ARD38179.1 B6E78_01060 B6E78_01060 ARD38257.1 ARD38257.1 ARD38263.1 ARD38263.1 ARD38275.1 ARD38275.1 ARD38376.1 ARD38376.1 ARD38459.1 ARD38459.1 dtpA dtpA B6E78_03325 B6E78_03325 ARD38554.1 ARD38554.1 ARD38640.1 ARD38640.1 lolD lolD ARD38642.1 ARD38642.1 fliI fliI fliJ fliJ fliP fliP fliQ fliQ ARD38714.1 ARD38714.1 lolA lolA ARD38943.1 ARD38943.1 ARD38944.1 ARD38944.1 ARD38948.1 ARD38948.1 ARD38949.1 ARD38949.1 ARD38950.1 ARD38950.1 ARD38951.1 ARD38951.1 ARD38952.1 ARD38952.1 ARD38953.1 ARD38953.1 ARD38954.1 ARD38954.1 ARD38955.1 ARD38955.1 ARD38956.1 ARD38956.1 tolB tolB tolR tolR tatE tatE B6E78_06940 B6E78_06940 ARD39186.1 ARD39186.1 bamE bamE bamB bamB bamD bamD ffh ffh ARD39364.1 ARD39364.1 secY secY ARD39631.1 ARD39631.1 dtpB dtpB secB secB yidC yidC ARD39864.1 ARD39864.1 ARD39969.1 ARD39969.1 ARD39970.1 ARD39970.1 tatA tatA tatB tatB tatC tatC secE secE ARD40160.1 ARD40160.1 ARD40161.1 ARD40161.1 ARD40181.1 ARD40181.1 B6E78_13900 B6E78_13900 secA secA ARD40945.1 ARD40945.1 ARD40406.1 ARD40406.1 ARD40446.1 ARD40446.1 ARD40447.1 ARD40447.1 bamA bamA ARD40480.1 ARD40480.1 ARD40491.1 ARD40491.1 ARD40538.1 ARD40538.1 ARD40540.1 ARD40540.1 ARD40543.1 ARD40543.1 ARD40547.1 ARD40547.1 ARD40552.1 ARD40552.1 ARD40553.1 ARD40553.1 ARD40555.1 ARD40555.1 ARD40560.1 ARD40560.1 ARD40561.1 ARD40561.1 ARD40563.1 ARD40563.1 ARD40564.1 ARD40564.1 ARD40565.1 ARD40565.1 ARD40566.1 ARD40566.1 B6E78_15360 B6E78_15360 ARD40579.1 ARD40579.1 yajC yajC secD secD secF secF tig tig bamC bamC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
flhBFlagellar biosynthesis protein FlhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (388 aa)
flhAFlagellar biosynthesis protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (696 aa)
lolBOuter membrane lipoprotein LolB; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. (206 aa)
ARD38179.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0303 family. (157 aa)
B6E78_01060ABC transporter substrate-binding protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (491 aa)
ARD38257.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0225 family. (160 aa)
ARD38263.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
ARD38275.1Energy transducer TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (283 aa)
ARD38376.1Peptide ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
ARD38459.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (867 aa)
dtpADipeptide/tripeptide permease A; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily. (490 aa)
B6E78_03325C4-dicarboxylate ABC transporter; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
ARD38554.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (491 aa)
ARD38640.1Lipoprotein-releasing system transmembrane protein LolE; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
lolDLipoprotein ABC transporter ATP-binding protein LolD; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (239 aa)
ARD38642.1Outer membrane-specific lipoprotein transporter subunit LolC; Part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
fliIFlagellum-specific ATP synthase FliI; Involved in type III protein export during flagellum assembly; Derived by automated computational analysis using gene prediction method: Protein Homology. (452 aa)
fliJFlagellar biosynthesis chaperone FliJ; Flagellar protein that affects chemotactic events. Belongs to the FliJ family. (146 aa)
fliPFlagellar biosynthetic protein FliP; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (246 aa)
fliQFlagellar export apparatus protein FliQ; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (89 aa)
ARD38714.1Flagellar biosynthetic protein FliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (261 aa)
lolAOuter membrane lipoprotein carrier protein LolA; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (204 aa)
ARD38943.1Type VI secretion system-associated protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
ARD38944.1EvpB family type VI secretion protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (495 aa)
ARD38948.1Type VI secretion system protein ImpG; Derived by automated computational analysis using gene prediction method: Protein Homology. (613 aa)
ARD38949.1Type VI secretion protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
ARD38950.1Type VI secretion protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (661 aa)
ARD38951.1Type VI secretion protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (100 aa)
ARD38952.1Type VI secretion protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
ARD38953.1Type VI secretion protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
ARD38954.1Type VI secretion system-associated protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
ARD38955.1Type VI secretion system protein ImpK; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
ARD38956.1Type VI secretion system protein ImpL; Derived by automated computational analysis using gene prediction method: Protein Homology. (1260 aa)
tolBProtein TolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane. (430 aa)
tolRProtein TolR; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (140 aa)
tatESec-independent protein translocase tatE; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA; Belongs to the TatA/E family. TatE subfamily. (66 aa)
B6E78_06940Permease; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
ARD39186.1ShlB/FhaC/HecB family hemolysin secretion/activation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (579 aa)
bamEOuter membrane protein assembly factor BamE; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (116 aa)
bamBOuter membrane protein assembly factor BamB; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (392 aa)
bamDHypothetical protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (245 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...] (453 aa)
ARD39364.1ShlB/FhaC/HecB family hemolysin secretion/activation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (580 aa)
secYPreprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (443 aa)
ARD39631.1Type II secretory pathway protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
dtpBDipeptide/tripeptide permease; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily. (491 aa)
secBProtein-export chaperone SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (153 aa)
yidCMembrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (541 aa)
ARD39864.1Membrane protein insertion efficiency factor YidD; Derived by automated computational analysis using gene prediction method: Protein Homology. (84 aa)
ARD39969.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
ARD39970.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
tatASec-independent protein translocase TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (89 aa)
tatBSec-independent translocase; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (176 aa)
tatCTwin arginine-targeting protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (262 aa)
secEElongation factor Tu; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. (127 aa)
ARD40160.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (578 aa)
ARD40161.1Translocation and assembly module TamB; Derived by automated computational analysis using gene prediction method: Protein Homology. (1254 aa)
ARD40181.1Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (111 aa)
B6E78_13900IS256 family transposase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (438 aa)
secAPreprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (902 aa)
ARD40945.1Type II secretory pathway protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
ARD40406.1Type II secretion system protein GspE; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
ARD40446.1Peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (161 aa)
ARD40447.1Peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
bamAOuter membrane protein assembly factor BamA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (795 aa)
ARD40480.1Molecular chaperone; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the skp family. (165 aa)
ARD40491.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (488 aa)
ARD40538.1Type III secretion protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
ARD40540.1EscJ/YscJ/HrcJ family type III secretion inner membrane ring protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
ARD40543.1EscF/YscF/HrpA family type III secretion system needle major subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (73 aa)
ARD40547.1EscC/YscC/HrcC family type III secretion system outer membrane ring protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (494 aa)
ARD40552.1Type III secretion protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa)
ARD40553.1Type III secretion protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
ARD40555.1Secretion protein EspA; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
ARD40560.1EscN/YscN/HrcN family type III secretion system ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (438 aa)
ARD40561.1EscV/YscV/HrcV family type III secretion system export apparatus protein; With SsaC forms part of a protein export system across the inner and outer cell membranes; part of the Salmonella pathogenicity island 2; part of the type III secretion system; Derived by automated computational analysis using gene prediction method: Protein Homology. (685 aa)
ARD40563.1EscR/YscR/HrcR family type III secretion system export apparatus protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
ARD40564.1EscS/YscS/HrcS family type III secretion system export apparatus protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (89 aa)
ARD40565.1EscT/YscT/HrcT family type III secretion system export apparatus protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
ARD40566.1EscU/YscU/HrcU family type III secretion system export apparatus switch protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
B6E78_15360IS1 family transposase; Frameshifted; internal stop; incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
ARD40579.1Hemolysin activation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
yajCPreprotein translocase subunit YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (110 aa)
secDProtein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (618 aa)
secFProtein translocase subunit SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (322 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (433 aa)
bamCOuter membrane protein assembly factor BamC; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (346 aa)
Your Current Organism:
Edwardsiella ictaluri
NCBI taxonomy Id: 67780
Other names: ATCC 33202, CCUG 18764, CIP 81.96, DSM 13697, E. ictaluri, JCM 16934, NCTC 12122, SECFDL GA 77-52
Server load: low (14%) [HD]
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