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pyrD | Dihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa) | ||||
tdk | Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa) | ||||
B6E78_02875 | IS5/IS1182 family transposase; Frameshifted; internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa) | ||||
pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (240 aa) | ||||
tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa) | ||||
pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa) | ||||
cmk | Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa) | ||||
ARD38861.1 | Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (760 aa) | ||||
ARD38862.1 | Ribonucleotide-diphosphate reductase subunit beta; B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa) | ||||
ARD40876.1 | 5'-deoxynucleotidase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (201 aa) | ||||
pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) | ||||
ARD39159.1 | Nucleoside triphosphate pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa) | ||||
ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) | ||||
surE | 5'/3'-nucleotidase SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (254 aa) | ||||
ARD39432.1 | Uridine phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa) | ||||
pyrI | Aspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (153 aa) | ||||
pyrB | Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa) | ||||
ARD40915.1 | Dihydropyrimidinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa) | ||||
ARD39621.1 | Cytosine deaminase; Catalyzes the deamination of cytosine to uracil and ammonia; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa) | ||||
ARD39638.1 | GMP/IMP nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (233 aa) | ||||
pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) | ||||
dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa) | ||||
ARD39974.1 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (255 aa) | ||||
ARD40938.1 | Anaerobic ribonucleoside triphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (712 aa) | ||||
deoA | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (440 aa) | ||||
deoD | Purine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa) | ||||
carA | Carbamoyl-phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa) | ||||
carB | Carbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (1073 aa) | ||||
thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) | ||||
ARD40462.1 | LOG family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (454 aa) | ||||
pyrH | Translation elongation factor Ts; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa) | ||||
ARD40602.1 | Noncanonical pyrimidine nucleotidase, YjjG family; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa) | ||||
ushA | Bifunctional UDP-sugar hydrolase/5'-nucleotidase; Catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (552 aa) | ||||
ppnP | Hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (95 aa) | ||||
upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) | ||||
cdd | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (295 aa) | ||||
dcd | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. (193 aa) |