(18 nodes) beta-Lactam resistance network (Edwardsiella ictaluri)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ARD40827.1	Porin; Allows for ions and hydrophilic solutes to cross the outer membrane; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Gram-negative porin family. (359 aa)
	ftsI	Peptidoglycan synthase; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (582 aa)
	ARD38264.1	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology. (544 aa)
	oppB	Oligopeptide transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
	ARD38266.1	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
	oppD	Oligopeptide ABC transporter ATP-binding protein OppD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (324 aa)
	ARD38268.1	With OppABCD is involved in the transport of oligopeptides; OppF and OppD are ATP-binding proteins; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
	mrdA	Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (637 aa)
	nagZ	beta-N-acetylhexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (340 aa)
	ARD38389.1	Oligopeptide ABC transporter substrate-binding protein OppA; Is involved in the transport of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology. (539 aa)
	mrdA-2	Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (631 aa)
	ARD39635.1	Carboxypeptidase/penicillin-binding protein 1A; Derived by automated computational analysis using gene prediction method: Protein Homology. (854 aa)
	B6E78_12130	Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
	ARD40080.1	Oligopeptide ABC transporter substrate-binding protein OppA; Is involved in the transport of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology. (544 aa)
	ftsI-2	Peptidoglycan glycosyltransferase FtsI; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. (587 aa)
	ARD40639.1	AmpG family muropeptide MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (493 aa)
	ARD40658.1	Multidrug efflux RND transporter permease subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (1050 aa)
	ARD40659.1	Efflux transporter periplasmic adaptor subunit; With AcrD and TolC forms a transport system involved in resistance to a number of compounds including lipophilic antibiotics; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (394 aa)

Your Current Organism:

Edwardsiella ictaluri

NCBI taxonomy Id: 67780
Other names: ATCC 33202, CCUG 18764, CIP 81.96, DSM 13697, E. ictaluri, JCM 16934, NCTC 12122, SECFDL GA 77-52

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARD38264.1	ARD38266.1	B6E78_01525	B6E78_01535	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.991
ARD38264.1	ARD38268.1	B6E78_01525	B6E78_01545	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	With OppABCD is involved in the transport of oligopeptides; OppF and OppD are ATP-binding proteins; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.990
ARD38264.1	ARD38389.1	B6E78_01525	B6E78_02285	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter substrate-binding protein OppA; Is involved in the transport of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.905
ARD38264.1	ARD40080.1	B6E78_01525	B6E78_12490	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter substrate-binding protein OppA; Is involved in the transport of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.904
ARD38264.1	oppB	B6E78_01525	B6E78_01530	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.992
ARD38264.1	oppD	B6E78_01525	B6E78_01540	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter ATP-binding protein OppD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.990
ARD38266.1	ARD38264.1	B6E78_01535	B6E78_01525	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.991
ARD38266.1	ARD38268.1	B6E78_01535	B6E78_01545	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	With OppABCD is involved in the transport of oligopeptides; OppF and OppD are ATP-binding proteins; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
ARD38266.1	ARD38389.1	B6E78_01535	B6E78_02285	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter substrate-binding protein OppA; Is involved in the transport of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
ARD38266.1	ARD40080.1	B6E78_01535	B6E78_12490	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter substrate-binding protein OppA; Is involved in the transport of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
ARD38266.1	oppB	B6E78_01535	B6E78_01530	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
ARD38266.1	oppD	B6E78_01535	B6E78_01540	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter ATP-binding protein OppD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.999
ARD38268.1	ARD38264.1	B6E78_01545	B6E78_01525	With OppABCD is involved in the transport of oligopeptides; OppF and OppD are ATP-binding proteins; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.990
ARD38268.1	ARD38266.1	B6E78_01545	B6E78_01535	With OppABCD is involved in the transport of oligopeptides; OppF and OppD are ATP-binding proteins; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
ARD38268.1	ARD38389.1	B6E78_01545	B6E78_02285	With OppABCD is involved in the transport of oligopeptides; OppF and OppD are ATP-binding proteins; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter substrate-binding protein OppA; Is involved in the transport of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.980
ARD38268.1	ARD40080.1	B6E78_01545	B6E78_12490	With OppABCD is involved in the transport of oligopeptides; OppF and OppD are ATP-binding proteins; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter substrate-binding protein OppA; Is involved in the transport of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.979
ARD38268.1	oppB	B6E78_01545	B6E78_01530	With OppABCD is involved in the transport of oligopeptides; OppF and OppD are ATP-binding proteins; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.998
ARD38268.1	oppD	B6E78_01545	B6E78_01540	With OppABCD is involved in the transport of oligopeptides; OppF and OppD are ATP-binding proteins; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter ATP-binding protein OppD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.984
ARD38389.1	ARD38264.1	B6E78_02285	B6E78_01525	Oligopeptide ABC transporter substrate-binding protein OppA; Is involved in the transport of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.905
ARD38389.1	ARD38266.1	B6E78_02285	B6E78_01535	Oligopeptide ABC transporter substrate-binding protein OppA; Is involved in the transport of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981