(45 nodes) Quorum sensing network (Edwardsiella ictaluri)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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Your Input:
	flhD	Flagellar transcriptional activator FlhD; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (115 aa)
	flhC	Transcriptional activator FlhC; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. (193 aa)
	ARD38219.1	long-chain-fatty-acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
	ARD38264.1	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology. (544 aa)
	oppB	Oligopeptide transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
	ARD38266.1	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
	oppD	Oligopeptide ABC transporter ATP-binding protein OppD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (324 aa)
	ARD38268.1	With OppABCD is involved in the transport of oligopeptides; OppF and OppD are ATP-binding proteins; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
	ARD38285.1	Anthranilate synthase component II; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
	ARD38286.1	Anthranilate synthase component I; Derived by automated computational analysis using gene prediction method: Protein Homology. (524 aa)
	ARD38321.1	Peptide ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
	ARD38322.1	Peptide ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
	ARD38323.1	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
	ARD38324.1	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
	ARD38325.1	Nickel ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (529 aa)
	ARD38389.1	Oligopeptide ABC transporter substrate-binding protein OppA; Is involved in the transport of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology. (539 aa)
	ARD38442.1	3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (348 aa)
	ribA	GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. (196 aa)
	ARD39030.1	3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (354 aa)
	ARD39055.1	LuxR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
	ARD39056.1	Acyl-homoserine-lactone synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)
	ARD39066.1	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
	ARD40900.1	3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (356 aa)
	ffh	Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...] (453 aa)
	luxS	S-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
	secY	Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (443 aa)
	ARD39666.1	cAMP-activated global transcriptional regulator CRP; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
	secB	Protein-export chaperone SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (153 aa)
	yidC	Membrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (541 aa)
	secE	Elongation factor Tu; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. (127 aa)
	fur-2	Transcriptional regulator Zur; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Fur family. (157 aa)
	ARD40080.1	Oligopeptide ABC transporter substrate-binding protein OppA; Is involved in the transport of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology. (544 aa)
	hfq	RNA-binding protein Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (102 aa)
	ARD40181.1	Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (111 aa)
	ARD40220.1	Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (454 aa)
	ARD40221.1	Two-component system response regulator QseB; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
	B6E78_14245	Transcriptional regulator LeuO; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (603 aa)
	secA	Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (902 aa)
	ARD40506.1	Two-component sensor histidine kinase; Part of the GlrKR two-component signal transduction system involved in the regulation of glmY; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
	ARD40514.1	Amino acid transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)
	ARD40515.1	Amino acid transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
	ARD40518.1	Amino acid transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (524 aa)
	ARD40519.1	Glutamate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the group II decarboxylase family. (464 aa)
	yajC	Preprotein translocase subunit YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (110 aa)
	ARD40957.1	Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (372 aa)

Your Current Organism:

Edwardsiella ictaluri

NCBI taxonomy Id: 67780
Other names: ATCC 33202, CCUG 18764, CIP 81.96, DSM 13697, E. ictaluri, JCM 16934, NCTC 12122, SECFDL GA 77-52

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARD38219.1	B6E78_14245	B6E78_01280	B6E78_14245	long-chain-fatty-acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transcriptional regulator LeuO; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.909
ARD38264.1	ARD38266.1	B6E78_01525	B6E78_01535	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.991
ARD38264.1	ARD38268.1	B6E78_01525	B6E78_01545	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	With OppABCD is involved in the transport of oligopeptides; OppF and OppD are ATP-binding proteins; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.990
ARD38264.1	ARD38323.1	B6E78_01525	B6E78_01885	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.538
ARD38264.1	ARD38324.1	B6E78_01525	B6E78_01890	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.568
ARD38264.1	ARD38325.1	B6E78_01525	B6E78_01895	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nickel ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.423
ARD38264.1	ARD38389.1	B6E78_01525	B6E78_02285	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter substrate-binding protein OppA; Is involved in the transport of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.905
ARD38264.1	ARD40080.1	B6E78_01525	B6E78_12490	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter substrate-binding protein OppA; Is involved in the transport of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.904
ARD38264.1	oppB	B6E78_01525	B6E78_01530	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.992
ARD38264.1	oppD	B6E78_01525	B6E78_01540	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter ATP-binding protein OppD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.990
ARD38266.1	ARD38264.1	B6E78_01535	B6E78_01525	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter substrate-binding protein OppA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.991
ARD38266.1	ARD38268.1	B6E78_01535	B6E78_01545	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	With OppABCD is involved in the transport of oligopeptides; OppF and OppD are ATP-binding proteins; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
ARD38266.1	ARD38321.1	B6E78_01535	B6E78_01875	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.421
ARD38266.1	ARD38322.1	B6E78_01535	B6E78_01880	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.629
ARD38266.1	ARD38324.1	B6E78_01535	B6E78_01890	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.890
ARD38266.1	ARD38325.1	B6E78_01535	B6E78_01895	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nickel ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.563
ARD38266.1	ARD38389.1	B6E78_01535	B6E78_02285	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter substrate-binding protein OppA; Is involved in the transport of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
ARD38266.1	ARD40080.1	B6E78_01535	B6E78_12490	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter substrate-binding protein OppA; Is involved in the transport of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
ARD38266.1	oppB	B6E78_01535	B6E78_01530	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
ARD38266.1	oppD	B6E78_01535	B6E78_01540	Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oligopeptide ABC transporter ATP-binding protein OppD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.999