STRINGSTRING
AOW94245.1 AOW94245.1 AOW91781.1 AOW91781.1 AOW91782.1 AOW91782.1 pyrE pyrE purA purA purN purN purH purH coaA coaA glyA glyA AOW91975.1 AOW91975.1 guaB guaB AOW94389.1 AOW94389.1 guaA guaA AOW92143.1 AOW92143.1 folD folD purK purK purE purE coaD coaD AOW94507.1 AOW94507.1 thyX thyX pyrR pyrR pyrB pyrB pyrC pyrC AOW94572.1 AOW94572.1 carA carA carB carB pyrF pyrF BFN03_07350 BFN03_07350 fmt fmt AOW92579.1 AOW92579.1 AOW92580.1 AOW92580.1 AOW92581.1 AOW92581.1 AOW94580.1 AOW94580.1 ribBA ribBA ribH ribH AOW92582.1 AOW92582.1 AOW92622.1 AOW92622.1 AOW92716.1 AOW92716.1 pyrD pyrD gcvP gcvP AOW92841.1 AOW92841.1 panB panB BFN03_10625 BFN03_10625 purU purU thyA thyA AOW94964.1 AOW94964.1 purM purM purF purF purQ purQ AOW95011.1 AOW95011.1 purC purC AOW95017.1 AOW95017.1 AOW93461.1 AOW93461.1 BFN03_15625 BFN03_15625 coaX coaX panD panD panC panC AOW95082.1 AOW95082.1 AOW93605.1 AOW93605.1 AOW95086.1 AOW95086.1 AOW93606.1 AOW93606.1 AOW93607.1 AOW93607.1 AOW95084.1 AOW95084.1 folE folE gcvT gcvT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AOW94245.1Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the globin family. (380 aa)
AOW91781.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
AOW91782.1Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the globin family. (392 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (176 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (434 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (229 aa)
purHBifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (508 aa)
coaAType I pantothenate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
AOW91975.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (299 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (507 aa)
AOW94389.1Inosine 5-monophosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
guaAGlutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. (502 aa)
AOW92143.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (98 aa)
folDBifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (289 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (403 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (175 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa)
AOW94507.1Riboflavin biosynthesis protein RibF; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (327 aa)
thyXFAD-dependent thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (233 aa)
pyrRN utilization substance protein B; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (209 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (447 aa)
AOW94572.1Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (386 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1122 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (266 aa)
BFN03_07350DNA-directed RNA polymerase subunit omega; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (414 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (289 aa)
AOW92579.1Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (492 aa)
AOW92580.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
AOW92581.1Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (360 aa)
AOW94580.1Riboflavin synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
ribBABifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (428 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (158 aa)
AOW92582.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
AOW92622.1Inosine 5-monophosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
AOW92716.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1189 aa)
pyrDDihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (356 aa)
gcvPGlycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (954 aa)
AOW92841.1Methylenetetrahydrofolate reductase [NAD(P)H]; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (340 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (289 aa)
BFN03_10625Hypothetical protein; Incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. (457 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (252 aa)
AOW94964.1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (164 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (543 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (225 aa)
AOW95011.1Phosphoribosylformylglycinamidine synthase subunit PurS; Derived by automated computational analysis using gene prediction method: Protein Homology. (71 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (313 aa)
AOW95017.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (454 aa)
AOW93461.1methionyl-tRNA formyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
BFN03_15625lysine--tRNA ligase; Incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (124 aa)
coaXPantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (273 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (148 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (297 aa)
AOW95082.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (294 aa)
AOW93605.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)
AOW95086.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
AOW93606.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
AOW93607.1Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (120 aa)
AOW95084.1Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
folEGTP cyclohydrolase I FolE; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (370 aa)
Your Current Organism:
Rhodococcus sp. WMMA185
NCBI taxonomy Id: 679318
Other names: R. sp. WMMA185
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