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CBG68370.1 CBG68370.1 CBG68373.1 CBG68373.1 CBG68380.1 CBG68380.1 CBG68449.1 CBG68449.1 SCAB_1971 SCAB_1971 SCAB_1981 SCAB_1981 arcB arcB arcA2 arcA2 dapF dapF dapA1 dapA1 dapB dapB lysA lysA aroA2 aroA2 CBG70151.1 CBG70151.1 SCAB_3091 SCAB_3091 dapE dapE CBG70228.1 CBG70228.1 txtD txtD CBG70695.1 CBG70695.1 SCAB_3841 SCAB_3841 CBG71192.1 CBG71192.1 asd1 asd1 lysC lysC CBG71297.1 CBG71297.1 argG argG CBG71620.1 CBG71620.1 pat pat CBG71711.1 CBG71711.1 aroQ aroQ asd1-2 asd1-2 CBG73208.1 CBG73208.1 trpD1 trpD1 trpE trpE aroH aroH CBG73827.1 CBG73827.1 CBG73828.1 CBG73828.1 CBG73829.1 CBG73829.1 CBG73830.1 CBG73830.1 hisD hisD hisC hisC hisB hisB CBG73834.1 CBG73834.1 hisH hisH priA priA CBG73837.1 CBG73837.1 hisF hisF hisI hisI trpE3 trpE3 trpC1 trpC1 trpB trpB trpA trpA CBG73873.1 CBG73873.1 aroQ-2 aroQ-2 dapD dapD dapA2 dapA2 CBG74074.1 CBG74074.1 CBG74185.1 CBG74185.1 CBG74186.1 CBG74186.1 argC argC argJ argJ argB argB argD argD argR argR argH argH CBG74437.1 CBG74437.1 aroE-2 aroE-2 aroC aroC aroK aroK aroB aroB hisE hisE hisG hisG rocD rocD CBG75105.1 CBG75105.1 trpF trpF SCAB_8401 SCAB_8401 hisC2 hisC2 hisD-2 hisD-2 CBG75871.1 CBG75871.1
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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CBG68370.1Putative aldolase; PMID: 21475791; PMID:10103039; PMID:12819191; PMID:9426000; cluster 0167 with SCAB67661 and SCAB1981; Belongs to the class-II DAHP synthase family. (412 aa)
CBG68373.1Putative chorismate-binding enzyme; PMID:8586283; PMID:9695930; cluster 0359 with SCAB67631 trpE. (732 aa)
CBG68380.1Putative oxidoreductase. (303 aa)
CBG68449.1Putative aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (468 aa)
SCAB_1971Putative aminodeoxychorismate synthase; PMID:9044253; PMID:14700630; PMID:14652074; PMID:11782498; PMID:8472954; PMID:15184904; PMID:8704974. (727 aa)
SCAB_1981Putative aldolase; PMID:8760910; cluster 0167 with SCAB12021 and SCAB67661; Belongs to the class-II DAHP synthase family. (484 aa)
arcBOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (335 aa)
arcA2Arginine deiminase. (407 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (289 aa)
dapA1Putative dihydrodipicolinate synthase 1; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa)
dapBPutative dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (250 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa)
aroA23-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (443 aa)
CBG70151.1Putative inositol monophosphatase. (266 aa)
SCAB_3091Putative amidohydrolase/peptidase/deacetylase. (418 aa)
dapESuccinyl-diaminopimelate desuccinylase. (359 aa)
CBG70228.1Putative aminotransferase. (366 aa)
txtDPutative oxygenase; Catalyzes the production of nitric oxide. Belongs to the NOS family. Bacterial NOS oxygenase subfamily. (390 aa)
CBG70695.1Conserved hypothetical protein. (107 aa)
SCAB_3841Putative homoserine dehydrogenase. (359 aa)
CBG71192.1Putative morphological differentiation protein; PMID: 10981703. (274 aa)
asd1Putative aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (355 aa)
lysCPutative aspartate kinase; Belongs to the aspartokinase family. (426 aa)
CBG71297.1Putative aspartate aminotransferase. (415 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (484 aa)
CBG71620.1Putative glutamine amidotransferase. (216 aa)
patPutative aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa)
CBG71711.1Prephenate dehydratase. (311 aa)
aroQPutative chorismate mutase. (218 aa)
asd1-2Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (351 aa)
CBG73208.1Putative lysine biosynthesis protein; Belongs to the DapA family. (311 aa)
trpD1Phosphoribosylanthranilate transferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (351 aa)
trpEPutative anthranilate synthase; PMID:9695930; PMID:8586283; cluster 0359 with SCAB12051. (620 aa)
aroHPutative 3-deoxy-7-phosphoheptulonate synthase; PMID:8760910; cluster 0167 with SCAB12021 and SCAB1981; Belongs to the class-II DAHP synthase family. (452 aa)
CBG73827.1Putative secreted protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (166 aa)
CBG73828.1Putative ATP-dependent protease. (246 aa)
CBG73829.1Conserved hypothetical protein. (347 aa)
CBG73830.1Putative membrane protein. (527 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (440 aa)
hisCHistidinol-phosphate aminotransferase; PMID:2199329; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (369 aa)
hisBImidazoleglycerol-phosphate dehydratase; PMID:2199329. (197 aa)
CBG73834.1Putative membrane protein; PMID:2199329; product not characterised in His cluster investigation PMID:2199329. (54 aa)
hisHImidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (215 aa)
priAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (242 aa)
CBG73837.1Conserved hypothetical protein; PMID:2199329; within histidine biosynthesis cluster. (130 aa)
hisFPutative imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa)
hisIPutative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (151 aa)
trpE3Putative anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] (492 aa)
trpC1Indoleglycerol phosphate synthase; PMID:10361288; Belongs to the TrpC family. (269 aa)
trpBTryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (427 aa)
trpATryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa)
CBG73873.1Putative chorismate mutase. (144 aa)
aroQ-2Dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (157 aa)
dapDPutative transferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (329 aa)
dapA2Putative dihydrodipicolinate synthase 2; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (315 aa)
CBG74074.1Putative cobalamin biosynthesis aminotransferase. (338 aa)
CBG74185.1Putative chorismate mutase. (120 aa)
CBG74186.1Putative secreted prephenate dehydrogenase/chorismate mutase; PMID:12060705; PMID:10770754; PMID:12480894; Cterm duplicated twice downstream: see SCAB71961 and SCAB71971. (361 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (343 aa)
argJGlutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (392 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (302 aa)
argDAcetylornithine aminotransferase; PMID: 11075930; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa)
argRArginine repressor; Regulates arginine biosynthesis genes. (178 aa)
argHArgininosuccinate lyase. (476 aa)
CBG74437.1Putative chorismate-binding enzyme. (347 aa)
aroE-2Quinate/shikimate dehydrogenase; Belongs to the shikimate dehydrogenase family. (279 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa)
aroKShikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (363 aa)
hisEphosphoribosyl-ATP pyrophosphatase. (90 aa)
hisGATP phosphoribosyltransferase (EC 2.4.2.17); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (290 aa)
rocDOrnithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (408 aa)
CBG75105.1Putative aminotransferase CobD. (587 aa)
trpFPutative N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (221 aa)
SCAB_8401Putative para-aminonezoic acid synthase; PMID:8472854; PMID:1178249; PMID:9044253; PMID:14700630; TTA-Leu codon(s) 459 may indicate regulation by BldA. (716 aa)
hisC2Putative phenylalanine aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (348 aa)
hisD-2Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (441 aa)
CBG75871.1Putative dihydrodipicolinate synthetase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. Belongs to the DapA family. (288 aa)
Your Current Organism:
Streptomyces scabiei
NCBI taxonomy Id: 680198
Other names: S. scabiei 87.22, Streptomyces scabiei 87.22, Streptomyces scabiei str. 87.22, Streptomyces scabiei strain 87.22
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