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CBG68370.1 | Putative aldolase; PMID: 21475791; PMID:10103039; PMID:12819191; PMID:9426000; cluster 0167 with SCAB67661 and SCAB1981; Belongs to the class-II DAHP synthase family. (412 aa) | ||||
CBG68373.1 | Putative chorismate-binding enzyme; PMID:8586283; PMID:9695930; cluster 0359 with SCAB67631 trpE. (732 aa) | ||||
CBG68380.1 | Putative oxidoreductase. (303 aa) | ||||
CBG68449.1 | Putative aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (468 aa) | ||||
SCAB_1971 | Putative aminodeoxychorismate synthase; PMID:9044253; PMID:14700630; PMID:14652074; PMID:11782498; PMID:8472954; PMID:15184904; PMID:8704974. (727 aa) | ||||
SCAB_1981 | Putative aldolase; PMID:8760910; cluster 0167 with SCAB12021 and SCAB67661; Belongs to the class-II DAHP synthase family. (484 aa) | ||||
arcB | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (335 aa) | ||||
arcA2 | Arginine deiminase. (407 aa) | ||||
dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (289 aa) | ||||
dapA1 | Putative dihydrodipicolinate synthase 1; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa) | ||||
dapB | Putative dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (250 aa) | ||||
lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa) | ||||
aroA2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (443 aa) | ||||
CBG70151.1 | Putative inositol monophosphatase. (266 aa) | ||||
SCAB_3091 | Putative amidohydrolase/peptidase/deacetylase. (418 aa) | ||||
dapE | Succinyl-diaminopimelate desuccinylase. (359 aa) | ||||
CBG70228.1 | Putative aminotransferase. (366 aa) | ||||
txtD | Putative oxygenase; Catalyzes the production of nitric oxide. Belongs to the NOS family. Bacterial NOS oxygenase subfamily. (390 aa) | ||||
CBG70695.1 | Conserved hypothetical protein. (107 aa) | ||||
SCAB_3841 | Putative homoserine dehydrogenase. (359 aa) | ||||
CBG71192.1 | Putative morphological differentiation protein; PMID: 10981703. (274 aa) | ||||
asd1 | Putative aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (355 aa) | ||||
lysC | Putative aspartate kinase; Belongs to the aspartokinase family. (426 aa) | ||||
CBG71297.1 | Putative aspartate aminotransferase. (415 aa) | ||||
argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (484 aa) | ||||
CBG71620.1 | Putative glutamine amidotransferase. (216 aa) | ||||
pat | Putative aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa) | ||||
CBG71711.1 | Prephenate dehydratase. (311 aa) | ||||
aroQ | Putative chorismate mutase. (218 aa) | ||||
asd1-2 | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (351 aa) | ||||
CBG73208.1 | Putative lysine biosynthesis protein; Belongs to the DapA family. (311 aa) | ||||
trpD1 | Phosphoribosylanthranilate transferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (351 aa) | ||||
trpE | Putative anthranilate synthase; PMID:9695930; PMID:8586283; cluster 0359 with SCAB12051. (620 aa) | ||||
aroH | Putative 3-deoxy-7-phosphoheptulonate synthase; PMID:8760910; cluster 0167 with SCAB12021 and SCAB1981; Belongs to the class-II DAHP synthase family. (452 aa) | ||||
CBG73827.1 | Putative secreted protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (166 aa) | ||||
CBG73828.1 | Putative ATP-dependent protease. (246 aa) | ||||
CBG73829.1 | Conserved hypothetical protein. (347 aa) | ||||
CBG73830.1 | Putative membrane protein. (527 aa) | ||||
hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (440 aa) | ||||
hisC | Histidinol-phosphate aminotransferase; PMID:2199329; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (369 aa) | ||||
hisB | Imidazoleglycerol-phosphate dehydratase; PMID:2199329. (197 aa) | ||||
CBG73834.1 | Putative membrane protein; PMID:2199329; product not characterised in His cluster investigation PMID:2199329. (54 aa) | ||||
hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (215 aa) | ||||
priA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (242 aa) | ||||
CBG73837.1 | Conserved hypothetical protein; PMID:2199329; within histidine biosynthesis cluster. (130 aa) | ||||
hisF | Putative imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa) | ||||
hisI | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (151 aa) | ||||
trpE3 | Putative anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] (492 aa) | ||||
trpC1 | Indoleglycerol phosphate synthase; PMID:10361288; Belongs to the TrpC family. (269 aa) | ||||
trpB | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (427 aa) | ||||
trpA | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa) | ||||
CBG73873.1 | Putative chorismate mutase. (144 aa) | ||||
aroQ-2 | Dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (157 aa) | ||||
dapD | Putative transferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (329 aa) | ||||
dapA2 | Putative dihydrodipicolinate synthase 2; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (315 aa) | ||||
CBG74074.1 | Putative cobalamin biosynthesis aminotransferase. (338 aa) | ||||
CBG74185.1 | Putative chorismate mutase. (120 aa) | ||||
CBG74186.1 | Putative secreted prephenate dehydrogenase/chorismate mutase; PMID:12060705; PMID:10770754; PMID:12480894; Cterm duplicated twice downstream: see SCAB71961 and SCAB71971. (361 aa) | ||||
argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (343 aa) | ||||
argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (392 aa) | ||||
argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (302 aa) | ||||
argD | Acetylornithine aminotransferase; PMID: 11075930; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa) | ||||
argR | Arginine repressor; Regulates arginine biosynthesis genes. (178 aa) | ||||
argH | Argininosuccinate lyase. (476 aa) | ||||
CBG74437.1 | Putative chorismate-binding enzyme. (347 aa) | ||||
aroE-2 | Quinate/shikimate dehydrogenase; Belongs to the shikimate dehydrogenase family. (279 aa) | ||||
aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa) | ||||
aroK | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa) | ||||
aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (363 aa) | ||||
hisE | phosphoribosyl-ATP pyrophosphatase. (90 aa) | ||||
hisG | ATP phosphoribosyltransferase (EC 2.4.2.17); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (290 aa) | ||||
rocD | Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (408 aa) | ||||
CBG75105.1 | Putative aminotransferase CobD. (587 aa) | ||||
trpF | Putative N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (221 aa) | ||||
SCAB_8401 | Putative para-aminonezoic acid synthase; PMID:8472854; PMID:1178249; PMID:9044253; PMID:14700630; TTA-Leu codon(s) 459 may indicate regulation by BldA. (716 aa) | ||||
hisC2 | Putative phenylalanine aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (348 aa) | ||||
hisD-2 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (441 aa) | ||||
CBG75871.1 | Putative dihydrodipicolinate synthetase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. Belongs to the DapA family. (288 aa) |