STRINGSTRING
CBG68971.1 CBG68971.1 CBG69081.1 CBG69081.1 CBG69276.1 CBG69276.1 CBG69442.1 CBG69442.1 CBG69530.1 CBG69530.1 leuD leuD leuC leuC CBG69790.1 CBG69790.1 CBG69797.1 CBG69797.1 leuB leuB serA serA ilvC ilvC ilvN ilvN CBG69811.1 CBG69811.1 CBG69813.1 CBG69813.1 CBG69828.1 CBG69828.1 thrB thrB thrC thrC thrA thrA CBG70269.1 CBG70269.1 CBG70496.1 CBG70496.1 CBG70529.1 CBG70529.1 metB metB SCAB_3581 SCAB_3581 ilvD ilvD cysA cysA vdh vdh CBG72086.1 CBG72086.1 serC serC SCAB_5301 SCAB_5301 CBG72490.1 CBG72490.1 sahH sahH leuA leuA metF metF SCAB_7021 SCAB_7021 metH metH CBG74438.1 CBG74438.1 metK metK CBG74759.1 CBG74759.1 SCAB_8031 SCAB_8031 CBG75250.1 CBG75250.1 metA metA CBG75618.1 CBG75618.1 ilvD-2 ilvD-2 CBG75842.1 CBG75842.1 CBG75917.1 CBG75917.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBG68971.1Putative aminotransferase. (402 aa)
CBG69081.1Putative transferase. (317 aa)
CBG69276.1Putative phosphotransferase. (351 aa)
CBG69442.1Putative bifunctional reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (1404 aa)
CBG69530.1Putative thiosulfate sulfurtransferase. (275 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (472 aa)
CBG69790.1Putative 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (534 aa)
CBG69797.1Putative branched-chain amino acid aminotransferase. (362 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (339 aa)
serAPutative D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
ilvCAcetolactate synthase small subunit; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa)
ilvNAcetolactate synthase small subunit. (175 aa)
CBG69811.1Putative acetolactate synthase; PMID: 10708373. (622 aa)
CBG69813.1Putative dehydrogenase. (333 aa)
CBG69828.1Conserved hypothetical protein. (336 aa)
thrBPutative homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (317 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa)
thrAHomoserine dehydrogenase. (433 aa)
CBG70269.1Putative pyridoxal-phosphate dependent enzyme. (320 aa)
CBG70496.1Putative aminotransferase. (384 aa)
CBG70529.1Putative amino acid deaminase. (431 aa)
metBCystathionine gamma-synthase. (384 aa)
SCAB_3581Putative oxidoreductase. (370 aa)
ilvDDihydroxy acid/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (617 aa)
cysAPutative cystathionine/methionine gamma-synthase/lyase. (381 aa)
vdhValine dehydrogenase (EC 1.4.1.-); PMID: 8320231; PMID: 8921870; PMID:10612726; PMID: 7928973; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (364 aa)
CBG72086.1Putative threonine synthase. (438 aa)
serCPutative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
SCAB_5301Putative cystathionine beta-synthase. (352 aa)
CBG72490.1Putative cystathionine beta-synthase. (462 aa)
sahHAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (485 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (573 aa)
metF5,10-methylenetetrahydrofolate reductase; PMID:12446651; PMID:9515933; Belongs to the methylenetetrahydrofolate reductase family. (292 aa)
SCAB_7021Conserved hypothetical protein. (278 aa)
metHPutative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1175 aa)
CBG74438.1Putative pyridoxal-phosphate-dependent transaminase; PMID:7814322. (273 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (392 aa)
CBG74759.1Putative cystathionine gamma-synthase. (414 aa)
SCAB_8031Putative threonine dehydratase. (326 aa)
CBG75250.1Putative lyase. (397 aa)
metAHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (350 aa)
CBG75618.1Putative Cys/Met metabolism enzyme. (484 aa)
ilvD-2Putative dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (570 aa)
CBG75842.1Putative acetolactate synthase large subunit; Belongs to the TPP enzyme family. (595 aa)
CBG75917.1Putative pyridoxal-phosphate dependent enzyme. (310 aa)
Your Current Organism:
Streptomyces scabiei
NCBI taxonomy Id: 680198
Other names: S. scabiei 87.22, Streptomyces scabiei 87.22, Streptomyces scabiei str. 87.22, Streptomyces scabiei strain 87.22
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