(79 nodes) Lipid catabolic process, and Enoyl-CoA hydratase/isomerase network (Streptomyces scabiei)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CBG68304.1	Short-chain dehydrogenase. (277 aa)
	CBG68471.1	Putative enoyl coA hydratase. (247 aa)
	fadB1	Putative fatty acid oxidative multifunctional enzyme. (724 aa)
	fadA4	Putative thiolase/acety-coA transferase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
	CBG68543.1	Conserved hypothetical protein; PMID:12183628; cluster 0385 with SCAB13961. (412 aa)
	CBG68557.1	Putative PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (282 aa)
	aceB1	Malate synthase; Belongs to the malate synthase family. (544 aa)
	CBG68989.1	Putative acetyl-coenzyme A synthetase. (559 aa)
	SCAB_20351	Hypothetical protein (fragment). (411 aa)
	CBG69210.1	Acetyl-coa acetyltransferase (thiolase); Belongs to the thiolase-like superfamily. Thiolase family. (408 aa)
	CBG69211.1	Fatty acid oxidation complex alpha-subunit. (711 aa)
	CBG69881.1	Putative enoyl-coA hydratase/isomerase family protein; Belongs to the enoyl-CoA hydratase/isomerase family. (255 aa)
	fadA	Putative acetyl-coA C-acetyltransferase FadA; PMID:11518326; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
	CBG69963.1	Putative 3-hydroxybutyryl-coA dehydrogenase. (282 aa)
	chcB	Putative acyl CoA isomerase; PMID: 10858310; Belongs to the enoyl-CoA hydratase/isomerase family. (263 aa)
	CBG70548.1	Putative enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (277 aa)
	CBG70910.1	Conserved hypothetical protein. (338 aa)
	CBG71597.1	Putative 3-hydroxyacyl-CoA dehydrogenase. (505 aa)
	CBG71758.1	Conserved hypothetical protein; Contains hydrophilic region possibly for attachment. (396 aa)
	CBG71759.1	Conserved hypothetical protein. (149 aa)
	CBG71760.1	Putative non-specific lipid transfer protein. (388 aa)
	echA12	Putative enoyl-CoA hydratase. (248 aa)
	CBG72201.1	Putative oxidoreductase. (388 aa)
	CBG72205.1	Putative oxidoreductase. (259 aa)
	CBG72212.1	Conserved hypothetical protein. (151 aa)
	CBG72216.1	Conserved hypothetical protein. (370 aa)
	CBG72217.1	Putative oxidoreductase. (442 aa)
	CBG72225.1	Putative oxidoreductase. (259 aa)
	CBG72226.1	Conserved hypothetical protein. (138 aa)
	CBG72227.1	Conserved hypothetical protein. (396 aa)
	CBG72228.1	Putative AMP-binding protein. (554 aa)
	fadA2	Putative acetyl-CoA C-acyltransferase; PMID:12101301; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
	fadE	acyl-CoA dehydrogenase. (385 aa)
	acdH	acyl-CoA dehydrogenase. (389 aa)
	hmgL	hydroxymethylglutaryl-CoA lyase. (316 aa)
	fadE7	acyl-CoA dehydrogenase. (385 aa)
	citA	Citrate synthase; PMID:11325948; see also SCAB51341 putative citrate synthase; Belongs to the citrate synthase family. (429 aa)
	CBG73349.1	Putative oxidoreductase. (578 aa)
	CBG73534.1	Putative acetyl-coA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
	CBG73560.1	Putative dehydrogenase. (286 aa)
	CBG73562.1	Putative dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (335 aa)
	SCAB_6631	Putative acyl-CoA thiolase; PMID:15563836; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
	CBG73861.1	Putative oxidoreductase. (325 aa)
	CBG73862.1	Putative oxidoreductase. (379 aa)
	CBG73863.1	Putative oxidoreductase. (265 aa)
	CBG73864.1	Putative TetR-family transcriptional regulator. (214 aa)
	CBG73865.1	Putative thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (385 aa)
	CBG73866.1	Putative oxidoreductase. (353 aa)
	CBG73867.1	Conserved hypothetical protein. (254 aa)
	CBG73868.1	Putative CoA-transferase. (282 aa)
	echA13	Putative enoyl-CoA hydratase. (263 aa)
	CBG73870.1	Putative dehydrogenase. (270 aa)
	CBG73871.1	Putative dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (308 aa)
	CBG74208.1	Putative acyl-CoA dehydrogenase. (396 aa)
	CBG74391.1	Putative 3-hydroxyacyl-CoA dehydrogenase. (277 aa)
	acd	acyl-CoA dehydrogenase. (399 aa)
	echA9	POSSIBLE ENOYL-COA HYDRATASE ECHA9 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE). (350 aa)
	CBG74589.1	Probable nonspecific lipid-transfer protein. (396 aa)
	CBG74590.1	CONSERVED HYPOTHETICAL PROTEIN. (141 aa)
	acsA	acetoacetyl-CoA synthetase. (655 aa)
	CBG74686.1	Putative oxidoreductase. (371 aa)
	CBG75220.1	Putative electron transfer flavoprotein, beta subunit. (253 aa)
	CBG75221.1	Putative electron transfer flavoprotein, alpha subunit. (320 aa)
	fadH	2,4-dienoyl-CoA reductase [NADPH]. (671 aa)
	fadE26	Putative acyl-coA dehydrogenase. (392 aa)
	CBG75430.1	CONSERVED HYPOTHETICAL PROTEIN. (370 aa)
	fadD4	PROBABLE FATTY-ACID-CoA LIGASE FADD4 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE). (497 aa)
	fadD19	PROBABLE FATTY-ACID-CoA LIGASE FADD19 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE). (553 aa)
	echA19	POSSIBLE ENOYL-COA HYDRATASE ECHA19 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE). (266 aa)
	CBG75438.1	CONSERVED HYPOTHETICAL PROTEIN. (313 aa)
	CBG75439.1	HYPOTHETICAL PROTEIN. (358 aa)
	ltp3	PROBABLE LIPID CARRIER PROTEIN OR KETO ACYL-COA THIOLASE LTP3. (388 aa)
	pcaF	beta-ketoadipyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
	CBG75716.1	Putative 3-hydroxybutyryl-CoA dehydratase (crotonase). (255 aa)
	CBG75717.1	Putative 3-hydroxyacyl-CoA dehydrogenase. (280 aa)
	CBG75880.1	Putative thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (408 aa)
	pcaI	Putative 3-oxoacid CoA-transferase subunit A; PMID:10742233. (251 aa)
	pcaJ	Putative 3-oxoacid CoA-transferase subunit B; PMID:10742233. (215 aa)
	CBG75999.1	Putative AMP-binding protein. (655 aa)

Your Current Organism:

Streptomyces scabiei

NCBI taxonomy Id: 680198
Other names: S. scabiei 87.22, Streptomyces scabiei 87.22, Streptomyces scabiei str. 87.22, Streptomyces scabiei strain 87.22

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBG68304.1	CBG73560.1	SCAB_11361	SCAB_65581	Short-chain dehydrogenase.	Putative dehydrogenase.	0.916
CBG68471.1	CBG68557.1	SCAB_13131	SCAB_14061	Putative enoyl coA hydratase.	Putative PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.492
CBG68471.1	CBG69210.1	SCAB_13131	SCAB_20951	Putative enoyl coA hydratase.	Acetyl-coa acetyltransferase (thiolase); Belongs to the thiolase-like superfamily. Thiolase family.	0.547
CBG68471.1	CBG69963.1	SCAB_13131	SCAB_28641	Putative enoyl coA hydratase.	Putative 3-hydroxybutyryl-coA dehydrogenase.	0.798
CBG68471.1	CBG71597.1	SCAB_13131	SCAB_45341	Putative enoyl coA hydratase.	Putative 3-hydroxyacyl-CoA dehydrogenase.	0.688
CBG68471.1	CBG71760.1	SCAB_13131	SCAB_47071	Putative enoyl coA hydratase.	Putative non-specific lipid transfer protein.	0.547
CBG68471.1	CBG72216.1	SCAB_13131	SCAB_51791	Putative enoyl coA hydratase.	Conserved hypothetical protein.	0.547
CBG68471.1	CBG72217.1	SCAB_13131	SCAB_51801	Putative enoyl coA hydratase.	Putative oxidoreductase.	0.487
CBG68471.1	CBG72225.1	SCAB_13131	SCAB_51881	Putative enoyl coA hydratase.	Putative oxidoreductase.	0.773
CBG68471.1	CBG72227.1	SCAB_13131	SCAB_51901	Putative enoyl coA hydratase.	Conserved hypothetical protein.	0.547
CBG68471.1	CBG73534.1	SCAB_13131	SCAB_65321	Putative enoyl coA hydratase.	Putative acetyl-coA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.547
CBG68471.1	CBG73861.1	SCAB_13131	SCAB_68651	Putative enoyl coA hydratase.	Putative oxidoreductase.	0.431
CBG68471.1	CBG73865.1	SCAB_13131	SCAB_68691	Putative enoyl coA hydratase.	Putative thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.547
CBG68471.1	CBG74208.1	SCAB_13131	SCAB_72171	Putative enoyl coA hydratase.	Putative acyl-CoA dehydrogenase.	0.417
CBG68471.1	CBG74391.1	SCAB_13131	SCAB_74071	Putative enoyl coA hydratase.	Putative 3-hydroxyacyl-CoA dehydrogenase.	0.751
CBG68471.1	CBG74589.1	SCAB_13131	SCAB_76141	Putative enoyl coA hydratase.	Probable nonspecific lipid-transfer protein.	0.547
CBG68471.1	CBG75439.1	SCAB_13131	SCAB_84921	Putative enoyl coA hydratase.	HYPOTHETICAL PROTEIN.	0.507
CBG68471.1	CBG75717.1	SCAB_13131	SCAB_87791	Putative enoyl coA hydratase.	Putative 3-hydroxyacyl-CoA dehydrogenase.	0.648
CBG68471.1	CBG75880.1	SCAB_13131	SCAB_89451	Putative enoyl coA hydratase.	Putative thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.547
CBG68471.1	SCAB_20351	SCAB_13131	SCAB_20351	Putative enoyl coA hydratase.	Hypothetical protein (fragment).	0.509