STRINGSTRING
CBG68221.1 CBG68221.1 CBG69196.1 CBG69196.1 hemE hemE CBG69247.1 CBG69247.1 CBG69467.1 CBG69467.1 hemH hemH gltX gltX CBG69967.1 CBG69967.1 hemL hemL hemB hemB hemD hemD hemC1 hemC1 hemA hemA CBG71300.1 CBG71300.1 CBG72614.1 CBG72614.1 CBG73568.1 CBG73568.1 CBG73627.1 CBG73627.1 cobS cobS cobT cobT cobU cobU bfr bfr ctaB ctaB CBG73991.1 CBG73991.1 CBG74075.1 CBG74075.1 CBG74076.1 CBG74076.1 cobB cobB cobO cobO CBG74080.1 CBG74080.1 cobQ cobQ cobD cobD CBG74428.1 CBG74428.1 cobT-2 cobT-2 CBG74430.1 CBG74430.1 hemC hemC SCAB_7891 SCAB_7891 CBG75685.1 CBG75685.1 CBG76021.1 CBG76021.1 cobN cobN cobG cobG SCAB_9791 SCAB_9791 cobI cobI SCAB_9811 SCAB_9811 cbiD cbiD cobM cobM cobL cobL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBG68221.1Conserved hypothetical protein. (175 aa)
CBG69196.1Putative oxidoreductase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (494 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (359 aa)
CBG69247.1Putative glutamyl-tRNA synthetase; Cluster 0490 with SCAB26661; Belongs to the class-I aminoacyl-tRNA synthetase family. (423 aa)
CBG69467.1Putative aminotransferase; PMID: 11598046; PMID:12644223; PMID:12825356; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (441 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (376 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (472 aa)
CBG69967.1Putative cobalamin adenosyltransferase; PMID: 14734568; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase. (439 aa)
hemBPorphobilinogen synthase; Belongs to the ALAD family. (311 aa)
hemDPutative uroporphyrinogen-III synthase. (583 aa)
hemC1Putative hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (322 aa)
hemAPutative glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (587 aa)
CBG71300.1Conserved hypothetical protein. (137 aa)
CBG72614.1Putative transcriptional regulator. (384 aa)
CBG73568.1Putative ribonuclease. (492 aa)
CBG73627.1Probable heme oxygenase. (222 aa)
cobSPutative cobalamin-5'-phosphate synthase (EC:2.7.8.26); Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (269 aa)
cobTPutativenicotinate-nucleotide-dimethylbenzimida zo lephosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (372 aa)
cobUPutative cobalamin biosynthesis protein; Likely adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase activity as in PMID: 7559521. (397 aa)
bfrPutative bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. (159 aa)
ctaBPutative cytochrome oxidase assembly factor; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (308 aa)
CBG73991.1Putative cytochrome assembly protein. (337 aa)
CBG74075.1Putative cobalamin biosynthesis protein; PMID:14612231; 63.376%aaid to S. seoulensis protein PMID:14612231 involved in superoxide dismutase expression; TTA-Leu codon(s) 27 may indicate regulation by BldA. (313 aa)
CBG74076.1Putative CbiG-like cobalamin biosynthesis protein. (185 aa)
cobBCobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (449 aa)
cobOcob(I)yrinic acid a,c-diamide adenosyltransferase (EC 2.5.1.17). (199 aa)
CBG74080.1Putative chelatase; PMID:2747617. (684 aa)
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (508 aa)
cobDCobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (319 aa)
CBG74428.1Putative SAM-dependent methyltransferase. (403 aa)
cobT-2Putative phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (1483 aa)
CBG74430.1Putative uroporphyrin-III methyltransferase. (393 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (296 aa)
SCAB_7891Putative oxygen-independent coproporphyrinogen III oxidase. (456 aa)
CBG75685.1Putative beta-galactosidase; Belongs to the glycosyl hydrolase 2 family. (682 aa)
CBG76021.1Putative precorrin-4 C11-methyltransferase. (172 aa)
cobNProbable cobalamin biosynthesis protein cobN. (1209 aa)
cobGPossible cobalamin biosynthesis protein CobG. (395 aa)
SCAB_9791Putative precorrin-8X methylmutase. (234 aa)
cobIPrecorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase; Probable bifunctional protein, CobI-CobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase. (496 aa)
SCAB_9811Putative precorrin-6X reductase. (247 aa)
cbiDPutative cobalamin biosynthesis-related protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (385 aa)
cobMPrecorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. (249 aa)
cobLprecorrin-6Y C5,15-methyltransferase [decarboxylating]. (428 aa)
Your Current Organism:
Streptomyces scabiei
NCBI taxonomy Id: 680198
Other names: S. scabiei 87.22, Streptomyces scabiei 87.22, Streptomyces scabiei str. 87.22, Streptomyces scabiei strain 87.22
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