STRINGSTRING
KLR59526.1 KLR59526.1 dinG dinG KLR59539.1 KLR59539.1 KLR59580.1 KLR59580.1 recG recG mfd mfd ruvA ruvA KLR59020.1 KLR59020.1 KLR58965.1 KLR58965.1 KLR59011.1 KLR59011.1 KLR58662.1 KLR58662.1 KLR58593.1 KLR58593.1 KLR58594.1 KLR58594.1 hrcA hrcA mutL mutL KLR58272.1 KLR58272.1 radA radA uvrB uvrB dnaQ dnaQ ruvC ruvC ruvB ruvB KLR57711.1 KLR57711.1 KLR57611.1 KLR57611.1 mutS mutS KLR57204.1 KLR57204.1 uvrA uvrA rnhB rnhB dnaE dnaE KLR57000.1 KLR57000.1 recA recA recX recX uvrC uvrC dnaE2 dnaE2 KLR56849.1 KLR56849.1 KLR56850.1 KLR56850.1 rnhA rnhA KLR56827.1 KLR56827.1 KLR56719.1 KLR56719.1 KLR56530.1 KLR56530.1 dinB dinB polA polA KLR56517.1 KLR56517.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLR59526.1DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
dinGATP-dependent DNA helicase DinG; DNA-dependent ATPase and 5'-3' DNA helicase. (729 aa)
KLR59539.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (368 aa)
KLR59580.1Type III restriction enzyme, res subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (899 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (715 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1167 aa)
ruvAATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (190 aa)
KLR59020.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (143 aa)
KLR58965.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (793 aa)
KLR59011.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (530 aa)
KLR58662.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (502 aa)
KLR58593.1Nucleotide-binding protein; Displays ATPase and GTPase activities. (287 aa)
KLR58594.1DNA repair protein; May be involved in recombinational repair of damaged DNA. (554 aa)
hrcAHrcA family transcriptional regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (334 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (656 aa)
KLR58272.1ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (623 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (460 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (698 aa)
dnaQDNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (237 aa)
ruvCHolliday junction resolvase; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (186 aa)
ruvBATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (356 aa)
KLR57711.1DNA polymerase III subunit chi; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
KLR57611.1Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1941 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (872 aa)
KLR57204.1DNA topoisomerase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (671 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1029 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (209 aa)
dnaEDNA polymerase III subunit alpha; Catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1179 aa)
KLR57000.1Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (688 aa)
recARecombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (373 aa)
recXRecombinase RecX; Modulates RecA activity; Belongs to the RecX family. (151 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (657 aa)
dnaE2DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1072 aa)
KLR56849.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
KLR56850.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
rnhARibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (148 aa)
KLR56827.1Methyltransferase type 11; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
KLR56719.1DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
KLR56530.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
dinBDNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (399 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (922 aa)
KLR56517.1DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (816 aa)
Your Current Organism:
Diaphorobacter sp. J551
NCBI taxonomy Id: 680496
Other names: D. sp. J5-51, Diaphorobacter sp. J5-51
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