STRINGSTRING
ANP48231.1 ANP48231.1 ANP48232.1 ANP48232.1 ANP48233.1 ANP48233.1 ANP48241.1 ANP48241.1 ANP48242.1 ANP48242.1 ANP48243.1 ANP48243.1 ANP48824.1 ANP48824.1 ANP48825.1 ANP48825.1 sucC sucC sucD sucD mdh mdh ANP49029.1 ANP49029.1 ANP49030.1 ANP49030.1 ANP49031.1 ANP49031.1 ANP49032.1 ANP49032.1 aspA aspA ANP49210.1 ANP49210.1 ANP49233.1 ANP49233.1 ANP49234.1 ANP49234.1 ANP49235.1 ANP49235.1 ANP49390.1 ANP49390.1 kgd kgd ANP56418.1 ANP56418.1 ANP49960.1 ANP49960.1 ANP56445.1 ANP56445.1 ANP50242.1 ANP50242.1 ANP50327.1 ANP50327.1 ANP50331.1 ANP50331.1 ANP50530.1 ANP50530.1 ANP50646.1 ANP50646.1 ANP50883.1 ANP50883.1 ANP50973.1 ANP50973.1 sdhA sdhA ANP50975.1 ANP50975.1 ANP56550.1 ANP56550.1 ANP51002.1 ANP51002.1 ANP51274.1 ANP51274.1 gabD2-2 gabD2-2 ANP54137.1 ANP54137.1 ANP54605.1 ANP54605.1 ANP54606.1 ANP54606.1 ANP54608.1 ANP54608.1 lipB lipB lipA lipA ANP54791.1 ANP54791.1 ANP54941.1 ANP54941.1 ANP55385.1 ANP55385.1 ANP55738.1 ANP55738.1 ANP55747.1 ANP55747.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANP48231.1Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
ANP48232.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
ANP48233.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
ANP48241.1Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
ANP48242.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
ANP48243.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
ANP48824.12-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
ANP48825.12-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (642 aa)
sucCsuccinate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
sucDsuccinate--CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
ANP49029.1Succinate dehydrogenase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (253 aa)
ANP49030.1Succinate dehydrogenase flavoprotein subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (584 aa)
ANP49031.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
ANP49032.1Succinate dehydrogenase, cytochrome b556 subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (114 aa)
aspAAspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
ANP49210.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (556 aa)
ANP49233.1Succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
ANP49234.1Fumarate reductase/succinate dehydrogenase flavoprotein subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (642 aa)
ANP49235.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
ANP49390.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
kgdAlpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology. (1268 aa)
ANP56418.1Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
ANP49960.1Citrate synthase/methylcitrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (387 aa)
ANP56445.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
ANP50242.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
ANP50327.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (884 aa)
ANP50331.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
ANP50530.1Lipoate--protein ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
ANP50646.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (154 aa)
ANP50883.1Isocitrate dehydrogenase, NADP-dependent; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (739 aa)
ANP50973.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (648 aa)
ANP50975.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
ANP56550.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
ANP51002.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
ANP51274.1Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
gabD2-2NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (498 aa)
ANP54137.1formyl-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CoA-transferase III family. (398 aa)
ANP54605.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
ANP54606.12-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (589 aa)
ANP54608.1Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (903 aa)
lipBLipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (265 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (329 aa)
ANP54791.1Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
ANP54941.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (466 aa)
ANP55385.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
ANP55738.1Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (366 aa)
ANP55747.1Malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; Derived by automated computational analysis using gene prediction method: Protein Homology. (570 aa)
Your Current Organism:
Streptomyces griseochromogenes
NCBI taxonomy Id: 68214
Other names: ATCC 14511, BCRC 11818, CBS 714.72, CCRC 11818, CCRC:11818, DSM 40499, IFO 13413, ISP 5499, JCM 4039, JCM 4764, KCTC 9027, NBRC 13413, NRRL B-12423, NRRL-ISP 5499, S. griseochromogenes, Streptomyces griseichromogenes
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