STRINGSTRING
ANP48231.1 ANP48231.1 ANP48232.1 ANP48232.1 ANP48233.1 ANP48233.1 ANP48241.1 ANP48241.1 ANP48242.1 ANP48242.1 ANP48243.1 ANP48243.1 acsA acsA ANP48620.1 ANP48620.1 ANP48824.1 ANP48824.1 ANP48825.1 ANP48825.1 mdh mdh ANP49074.1 ANP49074.1 ANP49082.1 ANP49082.1 pckG pckG aspA aspA ANP49210.1 ANP49210.1 ANP49390.1 ANP49390.1 ANP49490.1 ANP49490.1 ANP49511.1 ANP49511.1 ackA ackA ANP49513.1 ANP49513.1 ANP49679.1 ANP49679.1 ANP49728.1 ANP49728.1 ANP56406.1 ANP56406.1 ANP49907.1 ANP49907.1 ANP50076.1 ANP50076.1 ANP50154.1 ANP50154.1 ANP50242.1 ANP50242.1 ANP50329.1 ANP50329.1 ANP50355.1 ANP50355.1 ANP50391.1 ANP50391.1 ANP50434.1 ANP50434.1 ANP50617.1 ANP50617.1 ANP50750.1 ANP50750.1 ANP51183.1 ANP51183.1 ANP51292.1 ANP51292.1 AVL59_18225 AVL59_18225 ANP51525.1 ANP51525.1 ANP56635.1 ANP56635.1 ANP56744.1 ANP56744.1 ANP52503.1 ANP52503.1 ANP52796.1 ANP52796.1 ANP52838.1 ANP52838.1 ANP53378.1 ANP53378.1 ANP53913.1 ANP53913.1 ANP54124.1 ANP54124.1 ANP54434.1 ANP54434.1 ANP54450.1 ANP54450.1 ANP54605.1 ANP54605.1 ANP54608.1 ANP54608.1 ANP54734.1 ANP54734.1 ANP54752.1 ANP54752.1 ANP54791.1 ANP54791.1 ANP54889.1 ANP54889.1 leuA leuA ANP55081.1 ANP55081.1 ANP55223.1 ANP55223.1 ANP55385.1 ANP55385.1 ANP55509.1 ANP55509.1 ANP55708.1 ANP55708.1 ANP55747.1 ANP55747.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANP48231.1Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
ANP48232.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
ANP48233.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
ANP48241.1Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
ANP48242.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
ANP48243.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
ANP48620.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (486 aa)
ANP48824.12-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
ANP48825.12-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (642 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
ANP49074.1Betaine-aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
ANP49082.1acetyl-/propionyl-CoA carboxylase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (590 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (607 aa)
aspAAspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
ANP49210.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (556 aa)
ANP49390.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
ANP49490.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
ANP49511.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (475 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa)
ANP49513.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (696 aa)
ANP49679.1Citramalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (536 aa)
ANP49728.1Acylphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (93 aa)
ANP56406.1propionyl-CoA carboxylase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
ANP49907.1acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (72 aa)
ANP50076.1Malate synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malate synthase family. (532 aa)
ANP50154.1MBL fold metallo-hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
ANP50242.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
ANP50329.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (372 aa)
ANP50355.1Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (580 aa)
ANP50391.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (557 aa)
ANP50434.1Malate synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malate synthase family. (541 aa)
ANP50617.1PEP-utilizing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
ANP50750.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
ANP51183.1Alpha-hydroxy-acid oxidizing enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
ANP51292.1Acylphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (95 aa)
AVL59_18225Hypothetical protein; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1124 aa)
ANP51525.1CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (684 aa)
ANP56635.1MBL fold metallo-hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (308 aa)
ANP56744.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (452 aa)
ANP52503.1Lactate 2-monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
ANP52796.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (440 aa)
ANP52838.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
ANP53378.1Catalyzes the oxidation of acetaldehyde, benzaldehyde, propionaldehyde and other aldehydes; Derived by automated computational analysis using gene prediction method: Protein Homology. (507 aa)
ANP53913.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
ANP54124.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (462 aa)
ANP54434.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (478 aa)
ANP54450.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (385 aa)
ANP54605.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
ANP54608.1Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (903 aa)
ANP54734.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (483 aa)
ANP54752.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
ANP54791.1Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
ANP54889.1Pyruvate, phosphate dikinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PEP-utilizing enzyme family. (906 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (573 aa)
ANP55081.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (148 aa)
ANP55223.1acetyl/propionyl-CoA carboxylase subuit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (642 aa)
ANP55385.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
ANP55509.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
ANP55708.1pimeloyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (739 aa)
ANP55747.1Malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; Derived by automated computational analysis using gene prediction method: Protein Homology. (570 aa)
Your Current Organism:
Streptomyces griseochromogenes
NCBI taxonomy Id: 68214
Other names: ATCC 14511, BCRC 11818, CBS 714.72, CCRC 11818, CCRC:11818, DSM 40499, IFO 13413, ISP 5499, JCM 4039, JCM 4764, KCTC 9027, NBRC 13413, NRRL B-12423, NRRL-ISP 5499, S. griseochromogenes, Streptomyces griseichromogenes
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