STRINGSTRING
AOW85492.1 AOW85492.1 ung ung BC342_04315 BC342_04315 sbcD sbcD ung-2 ung-2 AOW85930.1 AOW85930.1 priA priA AOW86062.1 AOW86062.1 AOW86134.1 AOW86134.1 AOW91026.1 AOW91026.1 AOW86304.1 AOW86304.1 uvrC uvrC uvrA uvrA uvrB uvrB polA polA AOW86497.1 AOW86497.1 nfo nfo dnaG dnaG recO recO AOW91087.1 AOW91087.1 AOW86996.1 AOW86996.1 AOW87058.1 AOW87058.1 recD2 recD2 mfd mfd AOW87449.1 AOW87449.1 AOW87810.1 AOW87810.1 AOW87897.1 AOW87897.1 AOW87917.1 AOW87917.1 AOW87921.1 AOW87921.1 dnaA dnaA AOW87945.1 AOW87945.1 recF recF gyrB gyrB gyrA gyrA recR recR nth nth topA topA AOW88263.1 AOW88263.1 radA radA BC342_19935 BC342_19935 AOW91307.1 AOW91307.1 AOW88707.1 AOW88707.1 xseB xseB xseA xseA AOW91353.1 AOW91353.1 AOW89092.1 AOW89092.1 AOW89100.1 AOW89100.1 mutM mutM recA recA recX recX lexA lexA AOW89453.1 AOW89453.1 AOW89459.1 AOW89459.1 AOW89479.1 AOW89479.1 AOW89873.1 AOW89873.1 AOW90083.1 AOW90083.1 AOW90334.1 AOW90334.1 AOW90829.1 AOW90829.1 AOW90857.1 AOW90857.1 AOW90894.1 AOW90894.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AOW85492.1Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (500 aa)
unguracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (205 aa)
BC342_04315Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (998 aa)
sbcDExonuclease SbcCD subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (387 aa)
ung-2uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (227 aa)
AOW85930.1DNA polymerase IV; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
priAPrimosome assembly protein PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (722 aa)
AOW86062.1DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
AOW86134.15'-3' exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
AOW91026.1DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (572 aa)
AOW86304.1DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (718 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1007 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (718 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (907 aa)
AOW86497.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1179 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (298 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (637 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (249 aa)
AOW91087.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
AOW86996.1DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
AOW87058.1Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
recD2Helicase; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (752 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1184 aa)
AOW87449.1Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
AOW87810.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (760 aa)
AOW87897.1Serine/threonine protein kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
AOW87917.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (492 aa)
AOW87921.1Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa)
dnaAChromosomal replication initiation protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (651 aa)
AOW87945.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (376 aa)
recFDNA replication/repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (373 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (694 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (864 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (323 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (959 aa)
AOW88263.1DNA polymerase III subunit delta; Catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (469 aa)
BC342_19935Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (1658 aa)
AOW91307.1ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (659 aa)
AOW88707.1ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology. (829 aa)
xseBExodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (90 aa)
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (402 aa)
AOW91353.1DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1158 aa)
AOW89092.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (146 aa)
AOW89100.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
mutMDNA-formamidopyrimidine glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (286 aa)
recARecombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (375 aa)
recXRecombination regulator RecX; Modulates RecA activity; Belongs to the RecX family. (280 aa)
lexAATP-dependent helicase; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (259 aa)
AOW89453.1Recombinase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (719 aa)
AOW89459.1DNA topoisomerase IV subunit B; Derived by automated computational analysis using gene prediction method: Protein Homology. (707 aa)
AOW89479.1DNA topoisomerase IV; Derived by automated computational analysis using gene prediction method: Protein Homology. (818 aa)
AOW89873.1Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
AOW90083.1ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)
AOW90334.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (780 aa)
AOW90829.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (695 aa)
AOW90857.1DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
AOW90894.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (783 aa)
Your Current Organism:
Streptomyces pactum
NCBI taxonomy Id: 68249
Other names: ATCC 27456, BCRC 12076, CBS 461.69, CBS 734.72, CCRC 12076, CCRC:12076, DSM 40530, IFO 13433, IMET 43357, ISP 5530, JCM 4288, JCM 4809, KCTC 9165, LMG 19357, LMG:19357, NBRC 13433, NCIMB 9445, NRRL 2939, NRRL ISP-5530, NRRL-ISP 5530, S. pactum, Streptomyces pactum var. pactum, Streptomyces pactus
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