(51 nodes) Mismatch repair network (Tigriopus californicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TCAL_02571	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (160 aa)
	TCAL_01921	Uncharacterized protein. (469 aa)
	TCAL_07778	DNA_mis_repair domain-containing protein. (824 aa)
	TCAL_01348	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (460 aa)
	TCAL_04522	Uncharacterized protein. (453 aa)
	TCAL_08559	DDE_Tnp_IS1595 domain-containing protein. (256 aa)
	TCAL_02019	Uncharacterized protein. (72 aa)
	TCAL_17371	DDE_Tnp_IS1595 domain-containing protein. (275 aa)
	TCAL_15523	Uncharacterized protein. (116 aa)
	TCAL_09000	Uncharacterized protein. (218 aa)
	TCAL_10446	DDE_Tnp_IS1595 domain-containing protein. (257 aa)
	TCAL_15973	Uncharacterized protein. (128 aa)
	TCAL_10900	DNA_mis_repair domain-containing protein. (707 aa)
	TCAL_12766	DNA_MISMATCH_REPAIR_2 domain-containing protein. (1054 aa)
	TCAL_14077	DDE_Tnp_IS1595 domain-containing protein. (152 aa)
	TCAL_17385	DNA polymerase. (1070 aa)
	TCAL_17384	DNA polymerase. (622 aa)
	TCAL_05617	Uncharacterized protein. (186 aa)
	TCAL_03022	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (520 aa)
	TCAL_03216	Uncharacterized protein. (752 aa)
	TCAL_15123	Uncharacterized protein. (131 aa)
	TCAL_03029	AAA domain-containing protein. (641 aa)
	TCAL_11286	AAA domain-containing protein. (366 aa)
	TCAL_14223	DNA_pol_B_exo1 domain-containing protein. (163 aa)
	TCAL_01387	Exonuclease domain-containing protein. (381 aa)
	TCAL_05266	SH2 domain-containing protein. (827 aa)
	TCAL_00458	Uncharacterized protein. (311 aa)
	TCAL_05599	F-box domain-containing protein. (896 aa)
	TCAL_00802	Uncharacterized protein. (921 aa)
	TCAL_00398	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (688 aa)
	TCAL_16303	Uncharacterized protein. (228 aa)
	TCAL_00479	AAA domain-containing protein. (333 aa)
	TCAL_02653	Uncharacterized protein. (67 aa)
	TCAL_02035	DNA_MISMATCH_REPAIR_2 domain-containing protein. (855 aa)
	TCAL_00792	DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR). (992 aa)
	TCAL_00424	TPR_REGION domain-containing protein. (693 aa)
	TCAL_00810	AAA domain-containing protein. (351 aa)
	TCAL_04891	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	TCAL_11568	Exonuclease domain-containing protein. (454 aa)
	TCAL_05588	Uncharacterized protein. (464 aa)
	TCAL_12583	MUTSd domain-containing protein. (434 aa)
	TCAL_12582	DNA_MISMATCH_REPAIR_2 domain-containing protein. (271 aa)
	TCAL_05035	Uncharacterized protein. (162 aa)
	TCAL_01943	Uncharacterized protein. (409 aa)
	TCAL_11996	Uncharacterized protein. (831 aa)
	TCAL_08145	AAA domain-containing protein. (410 aa)
	TCAL_01056	Uncharacterized protein. (259 aa)
	TCAL_04471	SAS-6_N domain-containing protein. (344 aa)
	TCAL_16390	Uncharacterized protein. (195 aa)
	TCAL_08890	AAA domain-containing protein. (1758 aa)
	TCAL_04428	DNA polymerase. (725 aa)

Your Current Organism:

Tigriopus californicus

NCBI taxonomy Id: 6832
Other names: T. californicus, tidepool copepod

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TCAL_00398	TCAL_00424	A0A553NE30	A0A553NC59	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	TPR_REGION domain-containing protein.	0.825
TCAL_00398	TCAL_00479	A0A553NE30	A0A553NAV5	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	AAA domain-containing protein.	0.756
TCAL_00398	TCAL_00792	A0A553NE30	A0A553NC48	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.672
TCAL_00398	TCAL_00802	A0A553NE30	A0A553NEJ2	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.825
TCAL_00398	TCAL_00810	A0A553NE30	A0A553NDF4	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	AAA domain-containing protein.	0.778
TCAL_00398	TCAL_01056	A0A553NE30	A0A553P276	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.991
TCAL_00398	TCAL_01943	A0A553NE30	A0A553P7X0	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.630
TCAL_00398	TCAL_02035	A0A553NE30	A0A553NBT6	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.669
TCAL_00398	TCAL_03022	A0A553NE30	A0A553NU13	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family.	0.715
TCAL_00398	TCAL_03029	A0A553NE30	A0A553NTC1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	AAA domain-containing protein.	0.836
TCAL_00398	TCAL_03216	A0A553NE30	A0A553NTW9	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.527
TCAL_00398	TCAL_04428	A0A553NE30	A0A553NV97	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA polymerase.	0.699
TCAL_00398	TCAL_04471	A0A553NE30	A0A553NY27	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	SAS-6_N domain-containing protein.	0.876
TCAL_00398	TCAL_04891	A0A553NE30	A0A553NDL6	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.894
TCAL_00398	TCAL_05035	A0A553NE30	A0A553P7B2	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.507
TCAL_00398	TCAL_05588	A0A553NE30	A0A553NDS4	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.645
TCAL_00398	TCAL_05599	A0A553NE30	A0A553NEW4	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	F-box domain-containing protein.	0.484
TCAL_00398	TCAL_08145	A0A553NE30	A0A553P414	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	AAA domain-containing protein.	0.758
TCAL_00398	TCAL_08890	A0A553NE30	A0A553NVE8	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	AAA domain-containing protein.	0.734
TCAL_00398	TCAL_10900	A0A553NE30	A0A553PJU2	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA_mis_repair domain-containing protein.	0.597