(62 nodes) Homologous recombination network (Tigriopus californicus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TCAL_04325	SAP130_C domain-containing protein. (690 aa)
	TCAL_02003	Uncharacterized protein. (558 aa)
	TCAL_06598	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (867 aa)
	TCAL_08968	Helicase ATP-binding domain-containing protein. (1332 aa)
	TCAL_06764	Uncharacterized protein. (864 aa)
	TCAL_14427	EF-hand domain-containing protein. (190 aa)
	TCAL_08013	FHA domain-containing protein. (731 aa)
	TCAL_00103	Uncharacterized protein. (377 aa)
	TCAL_07415	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (673 aa)
	TCAL_09856	Uncharacterized protein; Belongs to the RecA family. (348 aa)
	TCAL_00515	Uncharacterized protein. (1522 aa)
	TCAL_09512	Uncharacterized protein. (141 aa)
	TCAL_06350	Uncharacterized protein. (779 aa)
	TCAL_00770	Fido domain-containing protein. (476 aa)
	TCAL_11272	ATP-dependent DNA helicase; Belongs to the helicase family. (1343 aa)
	TCAL_13441	Uncharacterized protein. (816 aa)
	TCAL_06940	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (498 aa)
	TCAL_04471	SAS-6_N domain-containing protein. (344 aa)
	TCAL_10028	Helicase ATP-binding domain-containing protein. (835 aa)
	TCAL_04459	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (355 aa)
	TCAL_16410	FHA domain-containing protein. (722 aa)
	TCAL_12356	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2965 aa)
	TCAL_01056	Uncharacterized protein. (259 aa)
	TCAL_12872	MPN domain-containing protein. (340 aa)
	TCAL_12871	MPN domain-containing protein. (140 aa)
	TCAL_10507	Uncharacterized protein. (182 aa)
	TCAL_01883	ERCC4 domain-containing protein. (707 aa)
	TCAL_05035	Uncharacterized protein. (162 aa)
	TCAL_01348	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (460 aa)
	TCAL_16866	Uncharacterized protein. (1032 aa)
	TCAL_08750	Uncharacterized protein. (269 aa)
	TCAL_01921	Uncharacterized protein. (469 aa)
	TCAL_02571	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (160 aa)
	TCAL_05691	Uncharacterized protein. (101 aa)
	TCAL_11145	Uncharacterized protein. (1220 aa)
	TCAL_08419	ATP-dependent DNA helicase; Belongs to the helicase family. (263 aa)
	TCAL_02166	Uncharacterized protein. (218 aa)
	TCAL_05719	Uncharacterized protein. (928 aa)
	TCAL_11816	RECA_2 domain-containing protein. (237 aa)
	TCAL_02165	Uncharacterized protein. (214 aa)
	TCAL_13535	RECA_2 domain-containing protein. (257 aa)
	TCAL_11237	PITH domain-containing protein. (217 aa)
	TCAL_08684	Uncharacterized protein. (233 aa)
	TCAL_08818	Smr domain-containing protein. (573 aa)
	TCAL_00799	Uncharacterized protein. (1436 aa)
	TCAL_02027	Uncharacterized protein. (602 aa)
	TCAL_04658	Zinc-hook domain-containing protein. (1199 aa)
	TCAL_01841	Uncharacterized protein. (355 aa)
	TCAL_05588	Uncharacterized protein. (464 aa)
	TCAL_00398	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (688 aa)
	TCAL_10249	Uncharacterized protein. (2239 aa)
	TCAL_07691	Uncharacterized protein. (1172 aa)
	TCAL_00458	Uncharacterized protein. (311 aa)
	TCAL_05522	Uncharacterized protein. (497 aa)
	TCAL_05266	SH2 domain-containing protein. (827 aa)
	TCAL_14223	DNA_pol_B_exo1 domain-containing protein. (163 aa)
	TCAL_15123	Uncharacterized protein. (131 aa)
	TCAL_05617	Uncharacterized protein. (186 aa)
	TCAL_17384	DNA polymerase. (622 aa)
	TCAL_17385	DNA polymerase. (1070 aa)
	TCAL_04428	DNA polymerase. (725 aa)
	TCAL_01943	Uncharacterized protein. (409 aa)

Your Current Organism:

Tigriopus californicus

NCBI taxonomy Id: 6832
Other names: T. californicus, tidepool copepod

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TCAL_00398	TCAL_00515	A0A553NE30	A0A553PB58	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.769
TCAL_00398	TCAL_00799	A0A553NE30	A0A553NC40	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.980
TCAL_00398	TCAL_01056	A0A553NE30	A0A553P276	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.991
TCAL_00398	TCAL_01841	A0A553NE30	A0A553ND66	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.966
TCAL_00398	TCAL_01883	A0A553NE30	A0A553P7K4	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	ERCC4 domain-containing protein.	0.759
TCAL_00398	TCAL_01943	A0A553NE30	A0A553P7X0	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.630
TCAL_00398	TCAL_02003	A0A553NE30	A0A553PNQ4	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.707
TCAL_00398	TCAL_04428	A0A553NE30	A0A553NV97	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA polymerase.	0.699
TCAL_00398	TCAL_04459	A0A553NE30	A0A553NZM1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.	0.962
TCAL_00398	TCAL_04471	A0A553NE30	A0A553NY27	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	SAS-6_N domain-containing protein.	0.876
TCAL_00398	TCAL_04658	A0A553NE30	A0A553NCV8	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Zinc-hook domain-containing protein.	0.779
TCAL_00398	TCAL_05035	A0A553NE30	A0A553P7B2	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.507
TCAL_00398	TCAL_05588	A0A553NE30	A0A553NDS4	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.645
TCAL_00398	TCAL_06350	A0A553NE30	A0A553PAC5	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.616
TCAL_00398	TCAL_06598	A0A553NE30	A0A553PN58	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.909
TCAL_00398	TCAL_06764	A0A553NE30	A0A553PKJ7	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.575
TCAL_00398	TCAL_06940	A0A553NE30	A0A553NVF4	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.979
TCAL_00398	TCAL_07415	A0A553NE30	A0A553PGI5	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.894
TCAL_00398	TCAL_07691	A0A553NE30	A0A553NET4	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.731
TCAL_00398	TCAL_08419	A0A553NE30	A0A553N7C7	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	ATP-dependent DNA helicase; Belongs to the helicase family.	0.527