(50 nodes) Fanconi anemia pathway network (Tigriopus californicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TCAL_00578	ERCC4 domain-containing protein. (884 aa)
	TCAL_07104	WD_REPEATS_REGION domain-containing protein. (655 aa)
	TCAL_08376	DUF1767 domain-containing protein. (526 aa)
	TCAL_01348	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (460 aa)
	TCAL_16866	Uncharacterized protein. (1032 aa)
	TCAL_01883	ERCC4 domain-containing protein. (707 aa)
	TCAL_01557	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (287 aa)
	TCAL_08443	Uncharacterized protein. (254 aa)
	TCAL_01080	Uncharacterized protein. (727 aa)
	TCAL_01056	Uncharacterized protein. (259 aa)
	TCAL_04459	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (355 aa)
	TCAL_10028	Helicase ATP-binding domain-containing protein. (835 aa)
	TCAL_01167	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2558 aa)
	TCAL_04471	SAS-6_N domain-containing protein. (344 aa)
	TCAL_11370	FAD_binding_3 domain-containing protein. (555 aa)
	TCAL_06940	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (498 aa)
	TCAL_03216	Uncharacterized protein. (752 aa)
	TCAL_02942	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (870 aa)
	TCAL_00398	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (688 aa)
	TCAL_02166	Uncharacterized protein. (218 aa)
	TCAL_00397	BTB domain-containing protein. (954 aa)
	TCAL_03541	USP domain-containing protein; Belongs to the peptidase C19 family. (819 aa)
	TCAL_03910	PAP-associated domain-containing protein. (404 aa)
	TCAL_00799	Uncharacterized protein. (1436 aa)
	TCAL_08687	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	TCAL_10989	UmuC domain-containing protein. (574 aa)
	TCAL_00417	UmuC domain-containing protein. (549 aa)
	TCAL_16616	DNA polymerase. (1494 aa)
	TCAL_01763	Uncharacterized protein. (1460 aa)
	TCAL_06254	Uncharacterized protein. (1369 aa)
	TCAL_11816	RECA_2 domain-containing protein. (237 aa)
	TCAL_02165	Uncharacterized protein. (214 aa)
	TCAL_11237	PITH domain-containing protein. (217 aa)
	TCAL_08818	Smr domain-containing protein. (573 aa)
	TCAL_09136	NTF2 domain-containing protein. (131 aa)
	TCAL_06558	Uncharacterized protein. (139 aa)
	TCAL_08339	Uncharacterized protein. (227 aa)
	TCAL_08334	Uncharacterized protein. (303 aa)
	TCAL_08338	Uncharacterized protein. (407 aa)
	TCAL_06598	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (867 aa)
	TCAL_08968	Helicase ATP-binding domain-containing protein. (1332 aa)
	TCAL_07854	Uncharacterized protein. (2431 aa)
	TCAL_10900	DNA_mis_repair domain-containing protein. (707 aa)
	TCAL_00103	Uncharacterized protein. (377 aa)
	TCAL_10365	Uncharacterized protein. (1187 aa)
	TCAL_01790	Uncharacterized protein. (1838 aa)
	TCAL_15974	Uncharacterized protein. (340 aa)
	TCAL_15975	POLAc domain-containing protein. (302 aa)
	TCAL_06879	Uncharacterized protein. (1377 aa)
	TCAL_14741	DNA_pol_B_exo1 domain-containing protein. (585 aa)

Your Current Organism:

Tigriopus californicus

NCBI taxonomy Id: 6832
Other names: T. californicus, tidepool copepod

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TCAL_00397	TCAL_00578	A0A553NE21	A0A553PDT1	BTB domain-containing protein.	ERCC4 domain-containing protein.	0.926
TCAL_00397	TCAL_00799	A0A553NE21	A0A553NC40	BTB domain-containing protein.	Uncharacterized protein.	0.677
TCAL_00397	TCAL_01557	A0A553NE21	A0A553P756	BTB domain-containing protein.	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family.	0.960
TCAL_00397	TCAL_01763	A0A553NE21	A0A553N9G8	BTB domain-containing protein.	Uncharacterized protein.	0.757
TCAL_00397	TCAL_01790	A0A553NE21	A0A553N7H5	BTB domain-containing protein.	Uncharacterized protein.	0.997
TCAL_00397	TCAL_01883	A0A553NE21	A0A553P7K4	BTB domain-containing protein.	ERCC4 domain-containing protein.	0.925
TCAL_00397	TCAL_02942	A0A553NE21	A0A553NQG0	BTB domain-containing protein.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.632
TCAL_00397	TCAL_04459	A0A553NE21	A0A553NZM1	BTB domain-containing protein.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.	0.626
TCAL_00397	TCAL_06598	A0A553NE21	A0A553PN58	BTB domain-containing protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.511
TCAL_00397	TCAL_06879	A0A553NE21	A0A553PGP2	BTB domain-containing protein.	Uncharacterized protein.	0.660
TCAL_00397	TCAL_06940	A0A553NE21	A0A553NVF4	BTB domain-containing protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.636
TCAL_00397	TCAL_07104	A0A553NE21	A0A553PCR6	BTB domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.404
TCAL_00397	TCAL_08376	A0A553NE21	A0A553PAJ1	BTB domain-containing protein.	DUF1767 domain-containing protein.	0.556
TCAL_00397	TCAL_08443	A0A553NE21	A0A553P3Z0	BTB domain-containing protein.	Uncharacterized protein.	0.854
TCAL_00397	TCAL_08687	A0A553NE21	A0A553NB67	BTB domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.446
TCAL_00397	TCAL_08968	A0A553NE21	A0A553PKM8	BTB domain-containing protein.	Helicase ATP-binding domain-containing protein.	0.634
TCAL_00397	TCAL_09136	A0A553NE21	A0A553N6K3	BTB domain-containing protein.	NTF2 domain-containing protein.	0.536
TCAL_00397	TCAL_10028	A0A553NE21	A0A553NZC6	BTB domain-containing protein.	Helicase ATP-binding domain-containing protein.	0.634
TCAL_00397	TCAL_11816	A0A553NE21	A0A553N7V2	BTB domain-containing protein.	RECA_2 domain-containing protein.	0.611
TCAL_00397	TCAL_16866	A0A553NE21	A0A553P9Q0	BTB domain-containing protein.	Uncharacterized protein.	0.605