(50 nodes) Valine, leucine and isoleucine degradation network (Micromonospora yangpuensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SCL59000.1	Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (255 aa)
	SCL65956.1	acetyl-CoA acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
	SCL65040.1	propionyl-CoA carboxylase alpha chain. (653 aa)
	SCL65036.1	Acetyl-CoA carboxylase, carboxyltransferase component. (533 aa)
	SCL62962.1	isobutyryl-CoA mutase small subunit. (134 aa)
	SCL61987.1	methylmalonyl-CoA epimerase. (155 aa)
	SCL61979.1	acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
	SCL61962.1	methylmalonyl-CoA mutase, N-terminal domain. (562 aa)
	SCL61294.1	methylglutaconyl-CoA hydratase. (267 aa)
	ilvE	Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (321 aa)
	SCL60808.1	2-oxoisovalerate dehydrogenase E1 component. (731 aa)
	SCL60405.1	acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit. (473 aa)
	SCL60327.1	2-oxoisovalerate dehydrogenase E1 component. (1104 aa)
	SCL60078.1	Muramoyltetrapeptide carboxypeptidase. (322 aa)
	SCL59963.1	Dihydrolipoamide dehydrogenase. (476 aa)
	SCL58535.1	enoyl-CoA hydratase. (348 aa)
	SCL58531.1	NAD binding domain of 6-phosphogluconate dehydrogenase. (44 aa)
	SCL58137.1	Acyl-CoA reductase; Belongs to the aldehyde dehydrogenase family. (493 aa)
	SCL56258.1	Site-specific recombinase XerD; Belongs to the 'phage' integrase family. (324 aa)
	SCL55715.1	Acyl-CoA dehydrogenase. (386 aa)
	SCL55318.1	Enoyl-CoA hydratase/carnithine racemase. (323 aa)
	SCL55272.1	acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	SCL55267.1	3-hydroxy-3-methylglutaryl CoA synthase. (474 aa)
	SCL55247.1	2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase. (250 aa)
	SCL55235.1	Acyl-CoA dehydrogenase. (382 aa)
	SCL55026.1	hydroxymethylglutaryl-CoA lyase. (300 aa)
	SCL54950.1	Malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase. (496 aa)
	SCL54884.1	Hypothetical protein. (99 aa)
	SCL52843.1	acetyl-CoA carboxylase carboxyltransferase subunit beta /acetyl-CoA carboxylase carboxyltransferase subunit alpha. (516 aa)
	SCL52809.1	acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein. (580 aa)
	SCL52666.1	Acyl-CoA dehydrogenase. (432 aa)
	SCL52127.1	acetyl-CoA acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (417 aa)
	SCL52125.1	3-hydroxyacyl-CoA dehydrogenase. (700 aa)
	SCL51599.1	acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
	xerC	Integrase/recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (333 aa)
	SCL51194.1	Branched-chain amino acid aminotransferase. (365 aa)
	SCL50958.1	Enoyl-CoA hydratase/carnithine racemase. (257 aa)
	SCL49918.1	acetoacetyl-CoA synthetase. (656 aa)
	SCL49909.1	Acyl-CoA dehydrogenase. (387 aa)
	SCL49766.1	acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (420 aa)
	SCL49553.1	propionyl-CoA carboxylase carboxyltransferase subunit. (527 aa)
	SCL49509.1	Biotin carboxyl carrier protein /biotin carboxylase. (583 aa)
	SCL49444.1	methylmalonyl-CoA mutase. (527 aa)
	SCL49407.1	Aldehyde dehydrogenase (acceptor). (483 aa)
	SCL46782.1	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. (527 aa)
	SCL46704.1	Valine dehydrogenase (NAD+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (360 aa)
	SCL46617.1	acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (430 aa)
	SCL46270.1	butyryl-CoA dehydrogenase. (384 aa)
	SCL46268.1	Acetyl-CoA carboxylase, carboxyltransferase component. (510 aa)
	SCL46264.1	hydroxymethylglutaryl-CoA lyase. (306 aa)

Your Current Organism:

Micromonospora yangpuensis

NCBI taxonomy Id: 683228
Other names: CGMCC 4.5736, DSM 45577, M. yangpuensis, Micromonospora sp. FXJ6.011, Micromonospora yangpuensis Zhang et al. 2012, NBRC 107727, strain FXJ6.011

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SCL46264.1	SCL46268.1	GA0070617_0206	GA0070617_0207	hydroxymethylglutaryl-CoA lyase.	Acetyl-CoA carboxylase, carboxyltransferase component.	0.837
SCL46264.1	SCL46270.1	GA0070617_0206	GA0070617_0208	hydroxymethylglutaryl-CoA lyase.	butyryl-CoA dehydrogenase.	0.469
SCL46264.1	SCL46617.1	GA0070617_0206	GA0070617_0330	hydroxymethylglutaryl-CoA lyase.	acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.871
SCL46264.1	SCL49509.1	GA0070617_0206	GA0070617_1203	hydroxymethylglutaryl-CoA lyase.	Biotin carboxyl carrier protein /biotin carboxylase.	0.427
SCL46264.1	SCL49553.1	GA0070617_0206	GA0070617_1217	hydroxymethylglutaryl-CoA lyase.	propionyl-CoA carboxylase carboxyltransferase subunit.	0.415
SCL46264.1	SCL49766.1	GA0070617_0206	GA0070617_1279	hydroxymethylglutaryl-CoA lyase.	acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.871
SCL46264.1	SCL49918.1	GA0070617_0206	GA0070617_1326	hydroxymethylglutaryl-CoA lyase.	acetoacetyl-CoA synthetase.	0.899
SCL46264.1	SCL50958.1	GA0070617_0206	GA0070617_1643	hydroxymethylglutaryl-CoA lyase.	Enoyl-CoA hydratase/carnithine racemase.	0.502
SCL46264.1	SCL51194.1	GA0070617_0206	GA0070617_1709	hydroxymethylglutaryl-CoA lyase.	Branched-chain amino acid aminotransferase.	0.608
SCL46264.1	SCL51599.1	GA0070617_0206	GA0070617_1829	hydroxymethylglutaryl-CoA lyase.	acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.698
SCL46264.1	SCL52125.1	GA0070617_0206	GA0070617_1986	hydroxymethylglutaryl-CoA lyase.	3-hydroxyacyl-CoA dehydrogenase.	0.613
SCL46264.1	SCL52127.1	GA0070617_0206	GA0070617_1987	hydroxymethylglutaryl-CoA lyase.	acetyl-CoA acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.871
SCL46264.1	SCL52809.1	GA0070617_0206	GA0070617_2185	hydroxymethylglutaryl-CoA lyase.	acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein.	0.427
SCL46264.1	SCL52843.1	GA0070617_0206	GA0070617_2194	hydroxymethylglutaryl-CoA lyase.	acetyl-CoA carboxylase carboxyltransferase subunit beta /acetyl-CoA carboxylase carboxyltransferase subunit alpha.	0.415
SCL46264.1	SCL55026.1	GA0070617_0206	GA0070617_2837	hydroxymethylglutaryl-CoA lyase.	hydroxymethylglutaryl-CoA lyase.	0.863
SCL46264.1	SCL55247.1	GA0070617_0206	GA0070617_2905	hydroxymethylglutaryl-CoA lyase.	2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase.	0.603
SCL46264.1	SCL55267.1	GA0070617_0206	GA0070617_2911	hydroxymethylglutaryl-CoA lyase.	3-hydroxy-3-methylglutaryl CoA synthase.	0.684
SCL46264.1	SCL55272.1	GA0070617_0206	GA0070617_2912	hydroxymethylglutaryl-CoA lyase.	acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.737
SCL46264.1	SCL55318.1	GA0070617_0206	GA0070617_2925	hydroxymethylglutaryl-CoA lyase.	Enoyl-CoA hydratase/carnithine racemase.	0.502
SCL46264.1	SCL58535.1	GA0070617_0206	GA0070617_3846	hydroxymethylglutaryl-CoA lyase.	enoyl-CoA hydratase.	0.502

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