STRINGSTRING
leuA leuA SCL65699.1 SCL65699.1 SCL55925.1 SCL55925.1 SCL56162.1 SCL56162.1 SCL56214.1 SCL56214.1 SCL56526.1 SCL56526.1 SCL56528.1 SCL56528.1 SCL56532.1 SCL56532.1 SCL56598.1 SCL56598.1 SCL65766.1 SCL65766.1 SCL56602.1 SCL56602.1 SCL55905.1 SCL55905.1 SCL55326.1 SCL55326.1 SCL55289.1 SCL55289.1 SCL55279.1 SCL55279.1 SCL55272.1 SCL55272.1 SCL55244.1 SCL55244.1 SCL54899.1 SCL54899.1 SCL54895.1 SCL54895.1 SCL54629.1 SCL54629.1 SCL54260.1 SCL54260.1 SCL53703.1 SCL53703.1 SCL52809.1 SCL52809.1 SCL52797.1 SCL52797.1 SCL51987.1 SCL51987.1 SCL51946.1 SCL51946.1 SCL51640.1 SCL51640.1 SCL51599.1 SCL51599.1 SCL51205.1 SCL51205.1 SCL51063.1 SCL51063.1 SCL50851.1 SCL50851.1 SCL49766.1 SCL49766.1 ppc ppc pckG pckG SCL49509.1 SCL49509.1 SCL49407.1 SCL49407.1 SCL49051.1 SCL49051.1 SCL48984.1 SCL48984.1 SCL48980.1 SCL48980.1 SCL47905.1 SCL47905.1 SCL47885.1 SCL47885.1 SCL47805.1 SCL47805.1 acsA acsA SCL47095.1 SCL47095.1 SCL47042.1 SCL47042.1 SCL46782.1 SCL46782.1 SCL46711.1 SCL46711.1 SCL46617.1 SCL46617.1 SCL46451.1 SCL46451.1 SCL46449.1 SCL46449.1 SCL46447.1 SCL46447.1 SCL46262.1 SCL46262.1 SCL45813.1 SCL45813.1 accA accA SCL57249.1 SCL57249.1 SCL57378.1 SCL57378.1 SCL57639.1 SCL57639.1 SCL58137.1 SCL58137.1 SCL58488.1 SCL58488.1 SCL58831.1 SCL58831.1 SCL59021.1 SCL59021.1 SCL59140.1 SCL59140.1 SCL59187.1 SCL59187.1 SCL59323.1 SCL59323.1 SCL59338.1 SCL59338.1 SCL59963.1 SCL59963.1 SCL60034.1 SCL60034.1 SCL60342.1 SCL60342.1 SCL60405.1 SCL60405.1 SCL60813.1 SCL60813.1 SCL60906.1 SCL60906.1 SCL61129.1 SCL61129.1 SCL61979.1 SCL61979.1 SCL62430.1 SCL62430.1 ackA ackA SCL62448.1 SCL62448.1 SCL62510.1 SCL62510.1 SCL62926.1 SCL62926.1 SCL64182.1 SCL64182.1 SCL64436.1 SCL64436.1 fumC fumC SCL64731.1 SCL64731.1 SCL65078.1 SCL65078.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (585 aa)
SCL65699.1Hypothetical protein. (126 aa)
SCL55925.1Fumarate reductase flavoprotein subunit. (455 aa)
SCL56162.1UPF0716 protein FxsA. (164 aa)
SCL56214.1Hypothetical protein. (233 aa)
SCL56526.1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (456 aa)
SCL56528.1Pyruvate dehydrogenase E1 component beta subunit. (334 aa)
SCL56532.1Pyruvate dehydrogenase E1 component alpha subunit. (392 aa)
SCL56598.1acetyl-CoA carboxylase, biotin carboxylase subunit. (483 aa)
SCL65766.1PhnB protein. (136 aa)
SCL56602.1acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (162 aa)
SCL55905.1Phosphoglycerate dehydrogenase. (373 aa)
SCL55326.1Hypothetical protein. (111 aa)
SCL55289.1Glyoxylase, beta-lactamase superfamily II. (364 aa)
SCL55279.1Catechol 2,3-dioxygenase. (164 aa)
SCL55272.1acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
SCL55244.1Hypothetical protein. (272 aa)
SCL54899.1Pyruvate dehydrogenase E1 component alpha subunit. (311 aa)
SCL54895.1Pyruvate dehydrogenase E1 component beta subunit. (326 aa)
SCL54629.1Deazaflavin-dependent oxidoreductase, nitroreductase family. (135 aa)
SCL54260.1methylmalonyl-CoA epimerase. (155 aa)
SCL53703.1Glyoxylase, beta-lactamase superfamily II. (239 aa)
SCL52809.1acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein. (580 aa)
SCL52797.1Antibiotic biosynthesis monooxygenase. (237 aa)
SCL51987.1Acyl-CoA synthetase (NDP forming). (853 aa)
SCL51946.1Malate dehydrogenase (oxaloacetate-decarboxylating). (492 aa)
SCL51640.1Deazaflavin-dependent oxidoreductase, nitroreductase family. (157 aa)
SCL51599.1acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
SCL51205.12-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (527 aa)
SCL51063.1Phosphoglycerate dehydrogenase. (328 aa)
SCL50851.1Biotin carboxylase. (617 aa)
SCL49766.1acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (420 aa)
ppcPhosphoenolpyruvate carboxylase, type 1; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (928 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (614 aa)
SCL49509.1Biotin carboxyl carrier protein /biotin carboxylase. (583 aa)
SCL49407.1Aldehyde dehydrogenase (acceptor). (483 aa)
SCL49051.1Glyoxalase-like domain-containing protein. (140 aa)
SCL48984.12-oxoglutarate ferredoxin oxidoreductase subunit alpha. (615 aa)
SCL48980.12-oxoglutarate ferredoxin oxidoreductase subunit beta. (355 aa)
SCL47905.1Predicted site-specific integrase-resolvase. (197 aa)
SCL47885.1Glyoxalase-like domain-containing protein. (307 aa)
SCL47805.1Argininosuccinate lyase. (429 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (663 aa)
SCL47095.1Hypothetical protein. (256 aa)
SCL47042.1DNA binding domain-containing protein, excisionase family. (88 aa)
SCL46782.1Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. (527 aa)
SCL46711.1DNA binding domain-containing protein, excisionase family. (69 aa)
SCL46617.1acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (430 aa)
SCL46451.1Pyruvate dehydrogenase E1 component alpha subunit. (391 aa)
SCL46449.1Pyruvate dehydrogenase E1 component beta subunit. (329 aa)
SCL46447.1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (530 aa)
SCL46262.1acetyl-CoA carboxylase, biotin carboxylase subunit. (445 aa)
SCL45813.1Rhodanese-related sulfurtransferase. (103 aa)
accAacetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (575 aa)
SCL57249.1Glyoxylase, beta-lactamase superfamily II. (209 aa)
SCL57378.1Dye decolorizing peroxidase. (409 aa)
SCL57639.1Catechol 2,3-dioxygenase. (126 aa)
SCL58137.1Acyl-CoA reductase; Belongs to the aldehyde dehydrogenase family. (493 aa)
SCL58488.1Dye decolorizing peroxidase. (426 aa)
SCL58831.1Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. (623 aa)
SCL59021.1Glyoxalase-like domain-containing protein. (278 aa)
SCL59140.1Uncharacterized conserved protein PhnB, glyoxalase superfamily. (136 aa)
SCL59187.1Glyoxylase, beta-lactamase superfamily II. (223 aa)
SCL59323.1Pyruvate kinase; Belongs to the pyruvate kinase family. (482 aa)
SCL59338.1Deazaflavin-dependent oxidoreductase, nitroreductase family. (143 aa)
SCL59963.1Dihydrolipoamide dehydrogenase. (476 aa)
SCL60034.1Hemerythrin HHE cation binding domain-containing protein; Manually curated. (156 aa)
SCL60342.1Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (912 aa)
SCL60405.1acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit. (473 aa)
SCL60813.1Phosphoglycerate dehydrogenase. (326 aa)
SCL60906.1Biotin carboxylase. (417 aa)
SCL61129.1Pyruvate phosphate dikinase. (870 aa)
SCL61979.1acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
SCL62430.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (689 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (372 aa)
SCL62448.1Malate dehydrogenase (oxaloacetate-decarboxylating). (392 aa)
SCL62510.1Biotin-requiring enzyme. (71 aa)
SCL62926.1Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. (316 aa)
SCL64182.1NUDIX domain-containing protein. (314 aa)
SCL64436.1Putative intracellular protease/amidase. (219 aa)
fumCFumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa)
SCL64731.1Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (555 aa)
SCL65078.1Glyoxylase, beta-lactamase superfamily II. (279 aa)
Your Current Organism:
Micromonospora yangpuensis
NCBI taxonomy Id: 683228
Other names: CGMCC 4.5736, DSM 45577, M. yangpuensis, Micromonospora sp. FXJ6.011, Micromonospora yangpuensis Zhang et al. 2012, NBRC 107727, strain FXJ6.011
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