(175 nodes) Biosynthesis of amino acids network (Microbotryum lychnidisdioicae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MVLG_04264	Glutamate-5-semialdehyde dehydrogenase. (458 aa)
	MVLG_04273	Uncharacterized protein. (133 aa)
	MVLG_04280	Homoserine kinase. (394 aa)
	MVLG_04304	AAA domain-containing protein; Belongs to the AAA ATPase family. (360 aa)
	MVLG_04336	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (206 aa)
	MVLG_04352	Carboxylic ester hydrolase; Belongs to the tannase family. (455 aa)
	MVLG_04353	Carboxylic ester hydrolase; Belongs to the tannase family. (572 aa)
	MVLG_04412	Uncharacterized protein. (547 aa)
	MVLG_04444	Aspartate aminotransferase. (440 aa)
	MVLG_04481	Uncharacterized protein. (1190 aa)
	MVLG_04483	Spermidine synthase; Belongs to the spermidine/spermine synthase family. (757 aa)
	MVLG_04543	Shikimate kinase. (208 aa)
	MVLG_04544	Uncharacterized protein. (594 aa)
	MVLG_04563	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities. (825 aa)
	MVLG_04627	Homoserine O-acetyltransferase. (499 aa)
	MVLG_04679	Enolase. (443 aa)
	MVLG_04773	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (512 aa)
	MVLG_04820	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (253 aa)
	MVLG_04924	Homoserine dehydrogenase. (394 aa)
	MVLG_04937	Threonine synthase. (562 aa)
	MVLG_04983	MFS domain-containing protein. (519 aa)
	MVLG_04984	MFS domain-containing protein. (527 aa)
	MVLG_05032	Uncharacterized protein. (260 aa)
	MVLG_05042	Aminotran_1_2 domain-containing protein. (582 aa)
	MVLG_05097	Threonine dehydratase. (631 aa)
	MVLG_05112	Uncharacterized protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (417 aa)
	MVLG_05169	Dihydroxy-acid dehydratase. (572 aa)
	MVLG_05178	Uncharacterized protein. (162 aa)
	MVLG_05254	Acetolactate synthase. (697 aa)
	MVLG_05297	Uncharacterized protein. (860 aa)
	TRM8	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (400 aa)
	MVLG_01892	Zn(2)-C6 fungal-type domain-containing protein. (858 aa)
	MVLG_05383	MFS domain-containing protein. (510 aa)
	MVLG_05414	Cysteine synthase. (383 aa)
	MVLG_05451	PALP domain-containing protein. (353 aa)
	MVLG_05469	Uncharacterized protein. (1350 aa)
	MVLG_05470	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family. (597 aa)
	MVLG_05472	D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (500 aa)
	MVLG_05630	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (691 aa)
	MVLG_05668	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (424 aa)
	MVLG_05956	Uncharacterized protein. (232 aa)
	MVLG_05997	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (456 aa)
	MVLG_06019	Glutamate synthase [NADPH]. (2136 aa)
	MVLG_06048	PNPLA domain-containing protein. (1030 aa)
	MVLG_06077	MFS domain-containing protein. (524 aa)
	MVLG_06078	MFS domain-containing protein. (518 aa)
	MVLG_06079	MFS domain-containing protein. (524 aa)
	MVLG_06086	Argininosuccinate lyase, variant. (470 aa)
	MVLG_06113	Uncharacterized protein. (564 aa)
	MVLG_06192	Zn(2)-C6 fungal-type domain-containing protein. (787 aa)
	MVLG_06238	Glyceraldehyde-3-phosphate dehydrogenase. (306 aa)
	MVLG_06345	Uncharacterized protein. (354 aa)
	MVLG_06358	Uncharacterized protein. (624 aa)
	MVLG_06370	Aminotran_1_2 domain-containing protein. (582 aa)
	MVLG_06373	Chorismate mutase. (288 aa)
	MVLG_06380	Uncharacterized protein. (588 aa)
	MVLG_06400	Prephenate dehydrogenase [NADP(+)]; Belongs to the prephenate/arogenate dehydrogenase family. (450 aa)
	MVLG_06403	Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (242 aa)
	MVLG_06454	Uncharacterized protein. (506 aa)
	MVLG_06533	HTH APSES-type domain-containing protein. (467 aa)
	MVLG_06550	Anthranilate synthase component I. (523 aa)
	MVLG_06601	Glutamine synthetase; Belongs to the glutamine synthetase family. (474 aa)
	MVLG_06655	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (326 aa)
	MVLG_06711	Triosephosphate isomerase. (254 aa)
	MVLG_06766	Uncharacterized protein. (96 aa)
	MVLG_06828	Uncharacterized protein. (167 aa)
	MVLG_06874	Uncharacterized protein. (49 aa)
	MVLG_06960	Uncharacterized protein. (732 aa)
	MVLG_07036	Phospho-2-dehydro-3-deoxyheptonate aldolase. (380 aa)
	MVLG_07064	Dihydroxy-acid dehydratase. (603 aa)
	MVLG_07090	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (394 aa)
	MVLG_07165	Uncharacterized protein. (763 aa)
	MVLG_07172	Carboxylic ester hydrolase; Belongs to the tannase family. (570 aa)
	MVLG_07203	5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase. (769 aa)
	MVLG_07256	Uncharacterized protein. (202 aa)
	MVLG_07277	Uncharacterized protein. (266 aa)
	MVLG_07315	APH domain-containing protein. (67 aa)
	MVLG_07318	APH domain-containing protein. (67 aa)
	MVLG_07337	Uncharacterized protein. (102 aa)
	MVLG_01910	Chorismate synthase. (407 aa)
	MVLG_01969	Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Belongs to the AlaDH/PNT family. (366 aa)
	MVLG_01970	Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (322 aa)
	MVLG_01982	M20_dimer domain-containing protein. (575 aa)
	MVLG_02012	Zn(2)-C6 fungal-type domain-containing protein. (900 aa)
	MVLG_02067	Uncharacterized protein. (117 aa)
	MVLG_02068	MFS domain-containing protein. (93 aa)
	MVLG_02069	Uncharacterized protein. (229 aa)
	MVLG_02129	Uncharacterized protein. (580 aa)
	MVLG_02435	Ribose-phosphate pyrophosphokinase. (383 aa)
	MVLG_02446	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (422 aa)
	MVLG_02568	Uncharacterized protein. (285 aa)
	MVLG_02592	Uncharacterized protein. (697 aa)
	MVLG_02593	Zn(2)-C6 fungal-type domain-containing protein. (770 aa)
	MVLG_02604	Citrate synthase; Belongs to the citrate synthase family. (470 aa)
	MVLG_02733	Phospho-2-dehydro-3-deoxyheptonate aldolase; Belongs to the class-II DAHP synthase family. (528 aa)
	MVLG_02944	Histidinol-phosphate aminotransferase. (410 aa)
	MVLG_03000	MFS domain-containing protein. (508 aa)
	MVLG_03022	2-isopropylmalate synthase. (628 aa)
	MVLG_03038	Asparagine synthetase. (606 aa)
	MVLG_03137	MFS domain-containing protein. (506 aa)
	MVLG_03158	Protein ARG5,6; In the N-terminal section; belongs to the acetylglutamate kinase family. (899 aa)
	MVLG_03232	Uncharacterized protein. (541 aa)
	MVLG_03270	Tryptophan synthase. (743 aa)
	MVLG_03300	Pyruvate kinase; Belongs to the pyruvate kinase family. (529 aa)
	MVLG_03343	Uncharacterized protein. (426 aa)
	MVLG_03373	NEDD8. (78 aa)
	MVLG_03410	MFS domain-containing protein. (529 aa)
	MVLG_03439	Uncharacterized protein. (380 aa)
	MVLG_03440	Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family. (203 aa)
	MVLG_03451	Argininosuccinate synthase. (437 aa)
	MVLG_03455	GHMP_kinases_N domain-containing protein. (892 aa)
	MVLG_03461	Arginine biosynthesis bifunctional protein ArgJ, mitochondrial; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate; Belongs to the ArgJ family. (520 aa)
	MVLG_03486	GFA domain-containing protein. (175 aa)
	MVLG_03492	Ketol-acid reductoisomerase, mitochondrial; Belongs to the ketol-acid reductoisomerase family. (399 aa)
	MVLG_03533	ACT domain-containing protein. (625 aa)
	MVLG_03551	Ribose-5-phosphate isomerase. (320 aa)
	MVLG_03653	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (418 aa)
	MVLG_03682	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (859 aa)
	MVLG_03764	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (379 aa)
	MVLG_03804	Citrate synthase; Belongs to the citrate synthase family. (489 aa)
	MVLG_03810	Dihydroxy-acid dehydratase. (577 aa)
	MVLG_03954	3-isopropylmalate dehydratase. (753 aa)
	MVLG_03955	Mac domain-containing protein. (241 aa)
	MVLG_04024	N-acetyltransferase domain-containing protein. (687 aa)
	MVLG_04081	PRA-CH domain-containing protein. (912 aa)
	MVLG_04092	MFS domain-containing protein. (374 aa)
	MVLG_04093	3-deoxy-7-phosphoheptulonate synthase. (422 aa)
	MVLG_04146	ATP phosphoribosyltransferase. (306 aa)
	MVLG_04223	O-acetylhomoserine (Thiol)-lyase. (433 aa)
	MVLG_04259	Beta_elim_lyase domain-containing protein. (393 aa)
	MVLG_04260	Arginase; Belongs to the arginase family. (315 aa)
	MVLG_01877	Uncharacterized protein. (1028 aa)
	MVLG_01835	3-phosphoshikimate 1-carboxyvinyltransferase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. In the 2nd section; belongs to the EPSP synthase family. In the 4th section; belongs to the type-I 3-dehydroquinase family. In the N-terminal section; belongs to the dehydroquinate synthase family. (1639 aa)
	MVLG_01825	Aspartate aminotransferase. (429 aa)
	MVLG_01773	Aminotran_5 domain-containing protein. (420 aa)
	MVLG_01721	PUA domain-containing protein. (572 aa)
	MVLG_01678	MFS domain-containing protein. (475 aa)
	MVLG_01677	MFS domain-containing protein. (476 aa)
	MVLG_01675	Acetolactate synthase I/III small subunit. (343 aa)
	MVLG_01615	MFS domain-containing protein. (694 aa)
	MVLG_01587	Uncharacterized protein. (191 aa)
	MVLG_01437	Uncharacterized protein. (654 aa)
	MVLG_01424	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (390 aa)
	MVLG_01330	L-aminoadipate-semialdehyde dehydrogenase. (1503 aa)
	MVLG_01306	MFS domain-containing protein. (505 aa)
	MVLG_01279	MFS domain-containing protein. (572 aa)
	MVLG_01125	Homoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. (722 aa)
	MVLG_01099	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (378 aa)
	MVLG_01098	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (368 aa)
	MVLG_00963	Uncharacterized protein. (360 aa)
	MVLG_00938	Homoisocitrate dehydrogenase. (364 aa)
	MVLG_00864	Glutamine synthetase. (354 aa)
	MVLG_00845	Uncharacterized protein. (675 aa)
	MVLG_00842	Prephenate dehydratase. (227 aa)
	MVLG_00799	Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (399 aa)
	MVLG_00763	MFS domain-containing protein. (486 aa)
	MVLG_00682	Uncharacterized protein. (321 aa)
	MVLG_00681	Uncharacterized protein. (228 aa)
	MVLG_00680	Uncharacterized protein. (240 aa)
	MVLG_00658	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (324 aa)
	MVLG_00626	Branched-chain amino acid aminotransferase. (371 aa)
	MVLG_00625	Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (488 aa)
	MVLG_00605	Aspartate-semialdehyde dehydrogenase. (362 aa)
	MVLG_00561	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (534 aa)
	MVLG_00505	Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (315 aa)
	MVLG_00435	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (799 aa)
	MVLG_00377	M20_dimer domain-containing protein. (847 aa)
	MVLG_00320	Uncharacterized protein. (665 aa)
	MVLG_00236	MFS domain-containing protein. (488 aa)
	MVLG_00152	5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase. (373 aa)
	MVLG_00144	Uncharacterized protein. (407 aa)
	MVLG_00124	Uncharacterized protein. (504 aa)
	MVLG_00098	Ribose-phosphate pyrophosphokinase. (389 aa)
	MVLG_00018	Uncharacterized protein. (190 aa)
	MVLG_00001	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1192 aa)

Your Current Organism:

Microbotryum lychnidisdioicae

NCBI taxonomy Id: 683840
Other names: M. lychnidis-dioicae p1A1 Lamole, Microbotryum lychnidis-dioicae p1A1 Lamole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MVLG_00001	MVLG_00098	U5GXS3	U5GY26	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Ribose-phosphate pyrophosphokinase.	0.611
MVLG_00001	MVLG_00144	U5GXS3	U5GY75	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Uncharacterized protein.	0.418
MVLG_00001	MVLG_00625	U5GXS3	U5GZM6	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.	0.708
MVLG_00001	MVLG_00658	U5GXS3	U5GZR2	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	0.501
MVLG_00001	MVLG_00799	U5GXS3	U5H060	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	0.478
MVLG_00001	MVLG_00864	U5GXS3	U5H0C9	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Glutamine synthetase.	0.808
MVLG_00001	MVLG_01675	U5GXS3	U5H2U3	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Acetolactate synthase I/III small subunit.	0.732
MVLG_00001	MVLG_01721	U5GXS3	U5H2Z3	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	PUA domain-containing protein.	0.555
MVLG_00001	MVLG_01825	U5GXS3	U5H3A2	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Aspartate aminotransferase.	0.894
MVLG_00001	MVLG_01892	U5GXS3	U5H3H8	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Zn(2)-C6 fungal-type domain-containing protein.	0.558
MVLG_00001	MVLG_02435	U5GXS3	U5H557	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Ribose-phosphate pyrophosphokinase.	0.611
MVLG_00001	MVLG_02446	U5GXS3	U5H568	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.609
MVLG_00001	MVLG_02592	U5GXS3	U5H5M4	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Uncharacterized protein.	0.558
MVLG_00001	MVLG_02593	U5GXS3	U5H5M5	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Zn(2)-C6 fungal-type domain-containing protein.	0.558
MVLG_00001	MVLG_02604	U5GXS3	U5H5N6	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Citrate synthase; Belongs to the citrate synthase family.	0.949
MVLG_00001	MVLG_03022	U5GXS3	U5H6Y2	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	2-isopropylmalate synthase.	0.890
MVLG_00001	MVLG_03232	U5GXS3	U5H7K7	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Uncharacterized protein.	0.558
MVLG_00001	MVLG_03300	U5GXS3	U5H7T0	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.970
MVLG_00001	MVLG_03451	U5GXS3	U5H885	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Argininosuccinate synthase.	0.461
MVLG_00001	MVLG_03533	U5GXS3	U5H8H4	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	ACT domain-containing protein.	0.402