STRINGSTRING
thiC thiC dxs dxs KRT18189.1 KRT18189.1 thiL thiL KRT17695.1 KRT17695.1 KRT17060.1 KRT17060.1 KRT17061.1 KRT17061.1 KRT16270.1 KRT16270.1 KRT16344.1 KRT16344.1 KRT16382.1 KRT16382.1 KRT15620.1 KRT15620.1 KRT14639.1 KRT14639.1 thiH thiH thiG thiG thiE thiE KRT13409.1 KRT13409.1 KRT13411.1 KRT13411.1 KRT13415.1 KRT13415.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (627 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (642 aa)
KRT18189.1Thiamine-phosphate pyrophosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (346 aa)
KRT17695.1Galanin; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
KRT17060.1Thiaminase II; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
KRT17061.1Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Catalyzes the formation hydroxymethylpyrimidine phosphate from hydroxymethylpyrimidine and the formation of of 4-amino-2-methyl-5-diphosphomethylpyrimidine from hydroxymethylpyrimidine phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
KRT16270.1Bleomycin resistance protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (129 aa)
KRT16344.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
KRT16382.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
KRT15620.1UDP pyrophosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (246 aa)
KRT14639.1Inositol-3-phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (441 aa)
thiHIn Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa)
thiEThiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa)
KRT13409.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
KRT13411.1Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology. (67 aa)
KRT13415.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (141 aa)
Your Current Organism:
Pedobacter ginsenosidimutans
NCBI taxonomy Id: 687842
Other names: JCM 16721, KACC 14530, P. ginsenosidimutans, Pedobacter ginsenosidimutans Yang et al. 2013, Pedobacter sp. THG-45, strain THG-45
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.