STRINGSTRING
AJG17591.1 AJG17591.1 AJG17605.1 AJG17605.1 AJG17606.1 AJG17606.1 AJG17685.1 AJG17685.1 AJG17687.1 AJG17687.1 AJG17861.1 AJG17861.1 AJG17863.1 AJG17863.1 AJG17865.1 AJG17865.1 AJG17866.1 AJG17866.1 AJG17867.1 AJG17867.1 AJG17988.1 AJG17988.1 AJG18070.1 AJG18070.1 AJG18190.1 AJG18190.1 ackA ackA AJG18196.1 AJG18196.1 AJG18297.1 AJG18297.1 AJG18461.1 AJG18461.1 AJG18483.1 AJG18483.1 leuA leuA AJG18688.1 AJG18688.1 accA accA AJG18871.1 AJG18871.1 AJG18888.1 AJG18888.1 AJG18889.1 AJG18889.1 AJG18891.1 AJG18891.1 AJG18938.1 AJG18938.1 AJG18944.1 AJG18944.1 AJG19462.1 AJG19462.1 AJG19515.1 AJG19515.1 AJG19538.1 AJG19538.1 pdhA pdhA AJG19540.1 AJG19540.1 AJG19541.1 AJG19541.1 AJG19552.1 AJG19552.1 AJG19626.1 AJG19626.1 AJG19677.1 AJG19677.1 AJG19683.1 AJG19683.1 AJG19778.1 AJG19778.1 AJG19856.1 AJG19856.1 AJG20005.1 AJG20005.1 gloB gloB acsA acsA AJG20201.1 AJG20201.1 AJG20255.1 AJG20255.1 accD accD mdh mdh AJG20387.1 AJG20387.1 ppc ppc AJG20884.1 AJG20884.1 AJG20950.1 AJG20950.1 AJG20967.1 AJG20967.1 AJG20968.1 AJG20968.1 AJG21092.1 AJG21092.1 AJG21124.1 AJG21124.1 AJG21362.1 AJG21362.1 AJG21388.1 AJG21388.1 pckG pckG leuA-2 leuA-2 AJG21788.1 AJG21788.1 AJG21795.1 AJG21795.1 AJG21796.1 AJG21796.1 AJG21991.1 AJG21991.1 AJG22140.1 AJG22140.1 AJG22312.1 AJG22312.1 AJG22327.1 AJG22327.1 AJG22332.1 AJG22332.1 AJG22418.1 AJG22418.1 AJG22428.1 AJG22428.1 AJG22445.1 AJG22445.1 AJG22451.1 AJG22451.1 AJG22477.1 AJG22477.1 AJG22496.1 AJG22496.1 AJG22531.1 AJG22531.1 AJG22546.1 AJG22546.1 AJG22587.1 AJG22587.1 AJG22676.1 AJG22676.1 AJG22680.1 AJG22680.1 AJG22681.1 AJG22681.1 AJG22682.1 AJG22682.1 AJG22683.1 AJG22683.1 AJG22907.1 AJG22907.1 AJG22923.1 AJG22923.1 AJG22961.1 AJG22961.1 AJG23035.1 AJG23035.1 AJG23043.1 AJG23043.1 AJG23067.1 AJG23067.1 AJG23100.1 AJG23100.1 AJG23103.1 AJG23103.1 AJG23170.1 AJG23170.1 AJG23174.1 AJG23174.1 AJG23495.1 AJG23495.1 AJG23896.1 AJG23896.1 AJG23904.1 AJG23904.1 AJG23910.1 AJG23910.1 AJG24063.1 AJG24063.1 AJG24132.1 AJG24132.1 pdhA-2 pdhA-2 AJG24148.1 AJG24148.1 AJG24149.1 AJG24149.1 fumC fumC AJG24284.1 AJG24284.1 AJG24292.1 AJG24292.1 AJG24393.1 AJG24393.1 AJG24402.1 AJG24402.1 AJG24430.1 AJG24430.1 AJG24690.1 AJG24690.1 AJG24820.1 AJG24820.1 AJG24825.1 AJG24825.1 AJG24942.1 AJG24942.1 AJG24984.1 AJG24984.1 fumC-2 fumC-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJG17591.13-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
AJG17605.1Methylcrotonyl-CoA carboxylase biotin-containing subunit. (262 aa)
AJG17606.1D-3-phosphoglycerate dehydrogenase. (313 aa)
AJG17685.1Protein acetyltransferase. (703 aa)
AJG17687.1Biotin carboxyl carrier protein. (70 aa)
AJG17861.1Succinate dehydrogenase flavoprotein subunit. (575 aa)
AJG17863.1Fumarate hydratase class I, aerobic. (291 aa)
AJG17865.1Succinate dehydrogenase cytochrome b-556 subunit. (117 aa)
AJG17866.1Succinate dehydrogenase hydrophobic anchor protein. (117 aa)
AJG17867.1Succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (237 aa)
AJG17988.1Lactoylglutathione lyase. (129 aa)
AJG18070.1Pyruvate kinase; Belongs to the pyruvate kinase family. (478 aa)
AJG18190.1Putative oxidoreductase, YbiC-like; Belongs to the LDH2/MDH2 oxidoreductase family. (349 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (408 aa)
AJG18196.1Phosphate acetyltransferase. (363 aa)
AJG18297.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (478 aa)
AJG18461.1Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (323 aa)
AJG18483.1NADP-dependent malic enzyme. (773 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (512 aa)
AJG18688.1Acetyl-coenzyme A synthetase. (577 aa)
accAAcetyl-coenzyme A carboxyl transferase alpha chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (323 aa)
AJG18871.1Acetyl-CoA hydrolase. (504 aa)
AJG18888.1Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (895 aa)
AJG18889.1Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (554 aa)
AJG18891.1Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. (594 aa)
AJG18938.13-ketoacyl-CoA thiolase or Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
AJG18944.13-ketoacyl-CoA thiolase or Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
AJG19462.13-ketoacyl-CoA thiolase or Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
AJG19515.13-ketoacyl-CoA thiolase or Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
AJG19538.1Acetyl-coenzyme A synthetase. (588 aa)
pdhAAcetoin dehydrogenase E1 component alpha-subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (340 aa)
AJG19540.1Acetoin dehydrogenase E1 component beta-subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (323 aa)
AJG19541.1Dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex. (384 aa)
AJG19552.1Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit. (663 aa)
AJG19626.13-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
AJG19677.1Betaine aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (477 aa)
AJG19683.1Aldehyde dehydrogenase. (474 aa)
AJG19778.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (794 aa)
AJG19856.1Malate synthase; Belongs to the malate synthase family. (528 aa)
AJG20005.1Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase. (478 aa)
gloBHydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (267 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
AJG20201.1Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
AJG20255.1Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (332 aa)
accDAcetyl-coenzyme A carboxyl transferase beta chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (322 aa)
AJG20387.1Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family. (548 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (1007 aa)
AJG20884.1D-Lactate dehydrogenase, cytochrome c-dependent. (472 aa)
AJG20950.1NADP-dependent malic enzyme. (774 aa)
AJG20967.1Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (152 aa)
AJG20968.1Biotin carboxylase of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (455 aa)
AJG21092.1Acylphosphate phosphohydrolase, putative. (90 aa)
AJG21124.1Aldehyde dehydrogenase B; Belongs to the aldehyde dehydrogenase family. (506 aa)
AJG21362.1Putative metal-binding enzyme, YcbL-like. (216 aa)
AJG21388.1Pyruvate kinase; Belongs to the pyruvate kinase family. (492 aa)
pckGPhosphoenolpyruvate carboxykinase [GTP]; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (618 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (566 aa)
AJG21788.1Dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex. (370 aa)
AJG21795.1Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. (466 aa)
AJG21796.1Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (410 aa)
AJG21991.1Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase. (549 aa)
AJG22140.1Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative. (689 aa)
AJG22312.13-ketoacyl-CoA thiolase or Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
AJG22327.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (483 aa)
AJG22332.1Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (904 aa)
AJG22418.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (486 aa)
AJG22428.1Acetyl-coenzyme A synthetase. (646 aa)
AJG22445.1Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
AJG22451.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (495 aa)
AJG22477.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1167 aa)
AJG22496.13-ketoacyl-CoA thiolase or Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (364 aa)
AJG22531.13-ketoacyl-CoA thiolase or Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (399 aa)
AJG22546.13-ketoacyl-CoA thiolase or Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
AJG22587.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1169 aa)
AJG22676.13-ketoacyl-CoA thiolase or Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
AJG22680.1NADP-dependent malic enzyme. (764 aa)
AJG22681.1Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. (589 aa)
AJG22682.1Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (540 aa)
AJG22683.1Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (897 aa)
AJG22907.13-ketoacyl-CoA thiolase or Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
AJG22923.1Acetyl-CoA acetyltransferase. (388 aa)
AJG22961.1D-3-phosphoglycerate dehydrogenase. (334 aa)
AJG23035.1Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (497 aa)
AJG23043.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (483 aa)
AJG23067.1Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (316 aa)
AJG23100.1Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative. (701 aa)
AJG23103.1Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
AJG23170.1Hypothetical protein; FIG00663289. (716 aa)
AJG23174.1Acetyl-CoA acetyltransferase. (378 aa)
AJG23495.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (471 aa)
AJG23896.1Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (303 aa)
AJG23904.13-ketoacyl-CoA thiolase or Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
AJG23910.13-ketoacyl-CoA thiolase or Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (385 aa)
AJG24063.1Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (314 aa)
AJG24132.1Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (900 aa)
pdhA-2Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (400 aa)
AJG24148.1Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit. (325 aa)
AJG24149.1Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (367 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
AJG24284.1Phosphate acetyltransferase. (346 aa)
AJG24292.1Pyruvate kinase; Belongs to the pyruvate kinase family. (476 aa)
AJG24393.1Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (891 aa)
AJG24402.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (506 aa)
AJG24430.1Dihydrolipoamide dehydrogenase. (484 aa)
AJG24690.1Metallo-beta-lactamase family protein. (251 aa)
AJG24820.1Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative. (718 aa)
AJG24825.13-ketoacyl-CoA thiolase or Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
AJG24942.1Chaperone protein hchA. (293 aa)
AJG24984.1Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative. (706 aa)
fumC-2Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (468 aa)
Your Current Organism:
Cupriavidus basilensis
NCBI taxonomy Id: 68895
Other names: C. basilensis, CCUG 49340, DSM 11853, LMG 18990, LMG 19474, LMG:18990, LMG:19474, Ralstonia basilensis, Wautersia basilensis, strain RK1
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