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GLE_0070 GLE_0070 gltB gltB acsA acsA aceB aceB aceA aceA GLE_0246 GLE_0246 putA putA mmsA mmsA GLE_0667 GLE_0667 aceF aceF GLE_0677 GLE_0677 gltA gltA cat2 cat2 gcvT gcvT gcvH gcvH alkJ alkJ pckA pckA prpE prpE prpB prpB prpC prpC GLE_1293 GLE_1293 prpD prpD gor gor gcvP gcvP GLE_1654 GLE_1654 GLE_1765 GLE_1765 proB proB proA proA GLE_1976 GLE_1976 mutA mutA acnA acnA acnB acnB mqo mqo GLE_2672 GLE_2672 GLE_2691 GLE_2691 fumC fumC sucA sucA sucB sucB lpdA lpdA GLE_2729 GLE_2729 GLE_2864 GLE_2864 GLE_2953 GLE_2953 GLE_3003 GLE_3003 sdhB sdhB sdhA sdhA sdhD sdhD sdhC sdhC GLE_3048 GLE_3048 tkB tkB GLE_3067 GLE_3067 GLE_3068 GLE_3068 GLE_3180 GLE_3180 mdh mdh sucD sucD sucC sucC glyA glyA glcF glcF pdhA pdhA pdhB pdhB GLE_4319 GLE_4319 aceE aceE maeB maeB ppc ppc GLE_5006 GLE_5006 glnA glnA GLE_5200 GLE_5200 GLE_5305 GLE_5305 icd icd
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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GLE_0070Glutamate synthase, small subunit. (510 aa)
gltBGlutamine amidotransferases class-II/glutamate synthase. (1497 aa)
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa)
aceBMalate synthase A. (544 aa)
aceAIsocitrate lyase. (433 aa)
GLE_0246Oxidoreductase. (288 aa)
putAProline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1089 aa)
mmsAMethylmalonate-semialdehyde dehydrogenase (acylating). (507 aa)
GLE_0667Alcohol dehydrogenase, zinc-containing. (351 aa)
aceFDihydrolipoyllysine-residue acetyltransferase. (474 aa)
GLE_0677Dihydrolipoyl dehydrogenase. (606 aa)
gltACitrate (Si)-synthase; Belongs to the citrate synthase family. (434 aa)
cat24-hydroxybutyrate coenzyme A transferase. (701 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (378 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (131 aa)
alkJAlcohol dehydrogenase. (530 aa)
pckAPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (601 aa)
prpEpropionate--CoA ligase. (631 aa)
prpBMethylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (293 aa)
prpC2-methylcitrate synthase; Belongs to the citrate synthase family. (384 aa)
GLE_1293FAD dependent oxidoreductase. (701 aa)
prpD2-methylcitrate dehydratase. (485 aa)
gorGlutathione reductase. (457 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (953 aa)
GLE_1654Isocitrate/isopropylmalate dehydrogenase. (337 aa)
GLE_1765Piperideine-6-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (510 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (404 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (426 aa)
GLE_1976Glu/Leu/Phe/Val dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (367 aa)
mutAmethylmalonyl-CoA mutase, alpha subunit; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1193 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (927 aa)
acnBAconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (861 aa)
mqoMalate:quinone oxidoreductase. (564 aa)
GLE_2672Aldehyde dehydrogenase (NAD) family protein; Belongs to the aldehyde dehydrogenase family. (475 aa)
GLE_2691Bacterial NAD-glutamate dehydrogenase family protein. (1703 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (489 aa)
sucAOxoglutarate dehydrogenase, E1 component. (943 aa)
sucBDihydrolipoyllysine-residue succinyltransferase, E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (404 aa)
lpdADihydrolipoyl dehydrogenase. (474 aa)
GLE_2729Quinone oxidoreductase, YhdH/YhfP family. (330 aa)
GLE_2864Sensory box histidine kinase. (1110 aa)
GLE_2953Hypothetical protein. (275 aa)
GLE_3003Glutamate synthase; Belongs to the glutamate synthase family. (541 aa)
sdhBSuccinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (262 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (597 aa)
sdhDSuccinate dehydrogenase, hydrophobic membrane anchor protein. (132 aa)
sdhCSuccinate dehydrogenase, cytochrome b556 subunit. (111 aa)
GLE_3048Aminomethyltransferase. (287 aa)
tkBTransketolase. (776 aa)
GLE_3067Oxidoreductase. (194 aa)
GLE_3068Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (504 aa)
GLE_3180Ferredoxin domain protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (107 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (429 aa)
glcFGlycolate oxidase, iron-sulfur subunit protein. (366 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (356 aa)
pdhBPyruvate dehydrogenase E1 component, beta subunit. (343 aa)
GLE_4319Branched-chain alpha-keto acid dehydrogenase subunit E2. (455 aa)
aceEPyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (901 aa)
maeBNADP-dependent malic enzyme. (770 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (920 aa)
GLE_5006Aldehyde dehydrogenase (NAD) family protein; Belongs to the aldehyde dehydrogenase family. (475 aa)
glnAGlutamine synthetase, type I. (469 aa)
GLE_5200Indolepyruvate ferredoxin oxidoreductase. (1232 aa)
GLE_5305Phenylacetaldehyde dehydrogenase (PAD); Belongs to the aldehyde dehydrogenase family. (495 aa)
icdIsocitrate dehydrogenase. (442 aa)
Your Current Organism:
Lysobacter enzymogenes
NCBI taxonomy Id: 69
Other names: ATCC 29487, DSM 2043, L. enzymogenes, LMG 8762, LMG:8762, Lysobacter enzymogenes subsp. enzymogenes, UASM 495
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