STRINGSTRING
GLE_0961 GLE_0961 waaA waaA lpxL lpxL GLE_0800 GLE_0800 GLE_0671 GLE_0671 GLE_2251 GLE_2251 kdsB kdsB lpxK lpxK GLE_4115 GLE_4115 GLE_1665 GLE_1665 kdsA kdsA lpxH lpxH GLE_1197 GLE_1197 GLE_1196 GLE_1196 GLE_1044 GLE_1044 GLE_0865 GLE_0865 GLE_0366 GLE_0366 GLE_0361 GLE_0361 GLE_0360 GLE_0360 GLE_0359 GLE_0359 GLE_4584 GLE_4584 GLE_4300 GLE_4300 GLE_4162 GLE_4162 lpxC lpxC ubiB ubiB GLE_0171 GLE_0171 lpxD lpxD lpxA lpxA lpxB lpxB GLE_3715 GLE_3715 GLE_3876 GLE_3876 GLE_4899 GLE_4899 GLE_4776 GLE_4776 kdkA kdkA GLE_1690 GLE_1690
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GLE_0961Outer membrane protein, OmpW family. (207 aa)
waaA3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (431 aa)
lpxLLipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (309 aa)
GLE_0800O-Antigen Polymerase. (458 aa)
GLE_0671Outer membrane protein, OmpW family. (210 aa)
GLE_2251Membrane protein. (397 aa)
kdsB3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (271 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (345 aa)
GLE_4115Sulfatase. (568 aa)
GLE_1665Heptosyltransferase. (363 aa)
kdsA3-deoxy-8-phosphooctulonate synthase; Belongs to the KdsA family. (277 aa)
lpxHUDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (244 aa)
GLE_1197Arabinose 5-phosphate isomerase. (340 aa)
GLE_11963-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (182 aa)
GLE_1044Ser/Thr protein phosphatase family protein. (277 aa)
GLE_0865Serine/threonine protein kinase protein family. (218 aa)
GLE_0366Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase. (344 aa)
GLE_0361Lipopolysaccharide core biosynthesis glycosyl transferase. (234 aa)
GLE_0360O-Antigen polymerase. (433 aa)
GLE_0359Dolichyl-phosphate-mannose-protein mannosyltransferase. (609 aa)
GLE_4584Outer membrane protein. (349 aa)
GLE_4300CaCA family Na+/Ca+ antiporter. (337 aa)
GLE_4162Aspartyl/asparaginyl beta-hydroxylase family. (300 aa)
lpxCUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (303 aa)
ubiB2-polyprenylphenol 6-hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. (600 aa)
GLE_0171Lipid A Biosynthesis N-terminal domain. (111 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (342 aa)
lpxAacyl-[acyl-carrier-protein]-UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (260 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (413 aa)
GLE_3715ABC transporter substrate binding protein. (564 aa)
GLE_3876Glycosyl transferase. (943 aa)
GLE_4899Sulfatase. (555 aa)
GLE_4776Glycosyl transferase, group 2 family protein. (334 aa)
kdkALipopolysaccharide kinase (Kdo/WaaP) family; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family. (249 aa)
GLE_1690Hypothetical protein. (267 aa)
Your Current Organism:
Lysobacter enzymogenes
NCBI taxonomy Id: 69
Other names: ATCC 29487, DSM 2043, L. enzymogenes, LMG 8762, LMG:8762, Lysobacter enzymogenes subsp. enzymogenes, UASM 495
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