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pdxT pdxT pdxS pdxS TK0219 TK0219 TK0269 TK0269 TK0270 TK0270 pfkC pfkC TK0475 TK0475 pyk pyk TK0551 TK0551 TK0673 TK0673 TK0674 TK0674 gyaR gyaR TK0705 TK0705 gap gap apgM apgM TK0955 TK0955 fba fba TK1108 TK1108 TK1109 TK1109 glkA glkA pgiA pgiA pgk pgk TK1188 TK1188 TK1292 TK1292 pckG pckG rpiA rpiA TK1497 TK1497 TK1711 TK1711 TK1777 TK1777 TK1893 TK1893 TK1966 TK1966 eno eno tpiA tpiA TK2132 TK2132 TK2163 TK2163 fbp fbp glmM glmM prs prs
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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pdxTPyridoxine biosynthesis amidotransferase, SNO family; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (197 aa)
pdxSPyridoxine/pyridoxal 5-phosphate biosynthesis protein, SOR/SNZ family; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (335 aa)
TK0219Sugar-phosphate nucleotidyltransferase. (413 aa)
TK0269Transketolase, C-terminal section. (306 aa)
TK0270Transketolase, N-terminal section. (219 aa)
pfkCADP-dependent phosphofructokinase; Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor. (461 aa)
TK0475Bifunctional D-arabino 3-hexulose-6-phosphate formaldehyde lyase/phosphohexuloisomerase. (406 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (478 aa)
TK0551D-isomer specific 2-hydroxyacid dehydrogenase. (333 aa)
TK0673Short-chain alcohol dehydrogenase. (259 aa)
TK0674Nucleotidyltransferase. (148 aa)
gyaRGlyoxylate reductase. (333 aa)
TK0705NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (non-phosphorylating); Belongs to the aldehyde dehydrogenase family. (507 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase (phosphorylating). (334 aa)
apgM2,3-Bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (411 aa)
TK0955Sugar-phosphate nucleotidyltransferase. (413 aa)
fbaDhnA-type fructose-1,6-bisphosphate aldolase; Belongs to the DeoC/FbaB aldolase family. (281 aa)
TK1108Phosphohexomutase; Catalyzes the interconversion of glucose 1-phosphate and glucose 6-phosphate, and the interconversion of mannose 1-phosphate and mannose 6-phosphate. Also displays low activity with deoxyribose 1- phosphate and glucosamine 1-phosphate; Belongs to the phosphohexose mutase family. (456 aa)
TK1109Bifunctional mannose-6-phosphate isomerase/mannose-1-phosphate guanylyl transferase; Belongs to the mannose-6-phosphate isomerase type 2 family. (465 aa)
glkAADP-dependent glucokinase; Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate. Involved in chitin degradation. (453 aa)
pgiAArchaeal glucose-6-phosphate isomerase; Belongs to the archaeal-type GPI family. (189 aa)
pgk3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (411 aa)
TK1188Sugar-phosphate nucleotydyltransferase. (419 aa)
TK1292Phosphoenolpyruvate synthetase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (793 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (623 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (229 aa)
TK1497Enolase-related protein. (341 aa)
TK1711Sugar-phosphate nucleotydyltransferase. (331 aa)
TK1777Phosphopentomutase; Catalyzes the conversion of deoxyribose 1-phosphate to deoxyribose 5-phosphate. Shows also weak activity with glucose 1- phosphate and mannose 1-phosphate. Could be involved in pentose biosynthesis. (450 aa)
TK1893Glycerate kinase-related protein, containing MOFRL domain (C-terminus). (248 aa)
TK1966D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (304 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (226 aa)
TK2132Fuculose-1-phosphate aldolase. (184 aa)
TK2163Tungsten-containing glyceraldehyde-3-phosphate:ferredoxin oxidoreductase. (652 aa)
fbpThermophile-specific fructose-1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). Does not display hydrolase activity against fructose 2,6-bisphosphate, fructose 6-phosphate, fructose 1- phosphate, glucose 6-phosphate, and glucose 1-phosphate. Exhibits only negligible activity on inositol-1- phosphate (IMP). Is essential for the growth of T.kodakaraensis under gluconeogen [...] (375 aa)
glmMPhosphohexomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity). Does not display phosphoglucomutase (PGM) or phosphomannomutase (PMM) activities. (449 aa)
prsPhosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). It can also use CTP and GTP as substrates in addition to ATP. (280 aa)
Your Current Organism:
Thermococcus kodakarensis
NCBI taxonomy Id: 69014
Other names: Pyrococcus sp. (strain KOD1), Pyrococcus sp. KOD1, T. kodakarensis KOD1, Thermococcus kodakaraensis KOD1, Thermococcus kodakarensis KOD1, Thermococcus kodakarensis str. KOD1, Thermococcus kodakarensis strain KOD1
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