STRINGSTRING
TK0111 TK0111 ef1b ef1b TK0126 TK0126 TK0143 TK0143 TK0306 TK0306 rps10 rps10 tuf tuf fusA fusA proS proS rpl37ae rpl37ae TK0617 TK0617 eif1a eif1a eif5a eif5a rpl21e rpl21e rpl35ae rpl35ae rpl37e rpl37e TK0976 TK0976 TK1004 TK1004 TK1031 TK1031 rps7 rps7 rpl30e rpl30e rpl44e rpl44e rps27e rps27e eif2a eif2a map map TK1190 TK1190 rps8e rps8e TK1205 TK1205 prf1 prf1 rps15 rps15 rps3ae rps3ae rps19e rps19e TK1278 TK1278 TK1297 TK1297 infB infB rpl24e rpl24e rps28e rps28e rpl39e rpl39e rpl31e rpl31e eif6 eif6 rpl18a rpl18a hel308 hel308 rpl12 rpl12 rpl10 rpl10 rpl1 rpl1 rpl11 rpl11 rpl15e rpl15e rpl40e rpl40e rps2 rps2 rps9 rps9 rpl13 rpl13 rpl18e rpl18e rps4 rps4 rps13 rps13 TK1507 TK1507 rpl14e rpl14e rpl34e rpl34e rpl15 rpl15 rpl30 rpl30 rps5 rps5 rpl18 rpl18 rpl19e rpl19e rpl32e rpl32e rpl6 rpl6 rps8 rps8 rps14 rps14 rpl5 rpl5 rps4e rps4e rpl24 rpl24 rpl14 rpl14 rps17 rps17 TK1534 TK1534 rpl29 rpl29 rps3 rps3 rpl22 rpl22 rps19 rps19 rpl2 rpl2 rpl23 rpl23 rpl4 rpl4 rpl3 rpl3 rpl10e rpl10e TK1581 TK1581 eif2b eif2b TK1636 TK1636 rps27ae rps27ae rps24e rps24e TK1708 TK1708 TK1857 TK1857 TK1915 TK1915 eif2g eif2g rps6e rps6e rps17e rps17e
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TK0111Predicted zinc-ribbon RNA-binding protein involved in translation. (62 aa)
ef1bTranslation elongation factor EF-1, beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (91 aa)
TK0126Predicted transcription regulator, containing DNA-binding HTH domain. (180 aa)
TK0143Nucleic acid-binding protein, containing C2H2 zinc-finger. (47 aa)
TK0306DEAD/DEAH box RNA helicase; Belongs to the DEAD box helicase family. (406 aa)
rps10SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
tufTranslation elongation factor EF-1, alpha subunit; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (428 aa)
fusATranslation elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF- [...] (732 aa)
proSprolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (481 aa)
rpl37aeLSU ribosomal protein L37AE. (86 aa)
TK0617U3 snoRNP component, archaeal imp4 homolog, containing Brix domain; Probably involved in the biogenesis of the ribosome. (208 aa)
eif1aTranslation initiation factor eIF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (117 aa)
eif5aTranslation initiation factor eIF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (136 aa)
rpl21eLSU ribosomal protein L21E; Belongs to the eukaryotic ribosomal protein eL21 family. (98 aa)
rpl35aeLSU ribosomal protein L35AE; Belongs to the eukaryotic ribosomal protein eL33 family. (86 aa)
rpl37eLSU ribosomal protein L37E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (63 aa)
TK0976snRNP component, Sm-like protein; Belongs to the snRNP Sm proteins family. (76 aa)
TK1004UDP-glucose 4-epimerase. (308 aa)
TK1031Predicted ATPase, RNase L inhibitor homolog. (594 aa)
rps7SSU ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (215 aa)
rpl30eLSU ribosomal protein L30E; Belongs to the eukaryotic ribosomal protein eL30 family. (102 aa)
rpl44eLSU ribosomal protein L44E; Binds to the 23S rRNA. (94 aa)
rps27eSSU ribosomal protein S27E. (65 aa)
eif2aTranslation initiation factor eIF-2, alpha subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (275 aa)
mapMethionyl aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. (295 aa)
TK1190Predicted GTPase, containing NOG1 domain. (358 aa)
rps8eSSU ribosomal protein S8E. (130 aa)
TK1205Phospholipid-binding protein, PBP family. (182 aa)
prf1Peptide chain release factor eRF1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (415 aa)
rps15SSU ribosomal protein S15P. (151 aa)
rps3aeSSU ribosomal protein S3AE; Belongs to the eukaryotic ribosomal protein eS1 family. (200 aa)
rps19eSSU ribosomal protein S19E; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (150 aa)
TK1278Double-stranded DNA-binding protein; Belongs to the PDCD5 family. (112 aa)
TK1297Nonsense-mediated mRNA decay protein NMD3 homolog. (390 aa)
infBTranslation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity). (1144 aa)
rpl24eLSU ribosomal protein L24E; Binds to the 23S rRNA. (67 aa)
rps28eSSU ribosomal protein S28E; Belongs to the eukaryotic ribosomal protein eS28 family. (70 aa)
rpl39eLSU ribosomal protein L39E; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
rpl31eLSU ribosomal protein L31E; Belongs to the eukaryotic ribosomal protein eL31 family. (90 aa)
eif6Translation initiation factor eIF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (229 aa)
rpl18aLSU ribosomal protein L20A. (77 aa)
hel308RNA helicase Ski2 homolog; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (1125 aa)
rpl12LSU ribosomal protein L12A; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (106 aa)
rpl10LSU ribosomal protein L10E; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (340 aa)
rpl1LSU ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (216 aa)
rpl11LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (165 aa)
rpl15eLSU ribosomal protein L15E; Belongs to the eukaryotic ribosomal protein eL15 family. (194 aa)
rpl40eLSU ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. (51 aa)
rps2SSU ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family. (201 aa)
rps9SSU ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (135 aa)
rpl13LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
rpl18eLSU ribosomal protein L18E; Belongs to the eukaryotic ribosomal protein eL18 family. (121 aa)
rps4SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (180 aa)
rps13SSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (149 aa)
TK1507Ribosomal RNA small subunit methyltransferase C. (195 aa)
rpl14eLSU ribosomal protein L14E; Belongs to the eukaryotic ribosomal protein eL14 family. (83 aa)
rpl34eLSU ribosomal protein L34E; Belongs to the eukaryotic ribosomal protein eL34 family. (90 aa)
rpl15LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (148 aa)
rpl30LSU ribosomal protein L30P. (155 aa)
rps5SSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (235 aa)
rpl18LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (201 aa)
rpl19eLSU ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (150 aa)
rpl32eLSU ribosomal protein L32E; Belongs to the eukaryotic ribosomal protein eL32 family. (126 aa)
rpl6LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (184 aa)
rps8SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rps14SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (56 aa)
rpl5LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (183 aa)
rps4eSSU ribosomal protein S4E; Belongs to the eukaryotic ribosomal protein eS4 family. (243 aa)
rpl24LSU ribosomal protein L24P; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (121 aa)
rpl14LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (141 aa)
rps17SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (114 aa)
TK1534Protein translation factor SUI1 homolog; Belongs to the SUI1 family. (98 aa)
rpl29LSU ribosomal protein L29P; Belongs to the universal ribosomal protein uL29 family. (66 aa)
rps3SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (209 aa)
rpl22LSU ribosomal protein L22P; This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (156 aa)
rps19SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (133 aa)
rpl2LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (239 aa)
rpl23LSU ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (86 aa)
rpl4LSU ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (255 aa)
rpl3LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (346 aa)
rpl10eLSU ribosomal protein L10E; Belongs to the universal ribosomal protein uL16 family. (182 aa)
TK1581Hypothetical protein, conserved, UPF0113 family. (169 aa)
eif2bTranslation initiation factor eIF-2, beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (142 aa)
TK1636Predicted exosome subunit, UPF0023 family. (236 aa)
rps27aeSSU ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family. (57 aa)
rps24eSSU ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family. (98 aa)
TK1708UDP-glucose 4-epimerase. (316 aa)
TK1857GTPase, MMR1/HSR1 family. (357 aa)
TK1915LSU ribosomal protein L41E. (37 aa)
eif2gTranslation initiation factor eIF-2, gamma subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (410 aa)
rps6eSSU ribosomal protein S6E; Belongs to the eukaryotic ribosomal protein eS6 family. (125 aa)
rps17eSSU ribosomal protein S17E; Belongs to the eukaryotic ribosomal protein eS17 family. (67 aa)
Your Current Organism:
Thermococcus kodakarensis
NCBI taxonomy Id: 69014
Other names: Pyrococcus sp. (strain KOD1), Pyrococcus sp. KOD1, T. kodakarensis KOD1, Thermococcus kodakaraensis KOD1, Thermococcus kodakarensis KOD1, Thermococcus kodakarensis str. KOD1, Thermococcus kodakarensis strain KOD1
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