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| | TK2304 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family, fused to N-terminal NusB regulator domain; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (450 aa) |
| | truD | tRNA pseudouridine synthase D; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (416 aa) |
| | hpkB | Archaeal histone B; Binds and compacts DNA (about 120 base pairs per nucleosome, corresponding to four histone dimers) to form nucleosome-like structures. (67 aa) |
| | TK2275 | RNA-binding protein, containing PUA domain. (172 aa) |
| | TK2261 | Transcription regulator, SpoVT/AbrB family. (78 aa) |
| | TK2259 | Predicted transcription regulator, penicillinase repressor family. (121 aa) |
| | TK2245 | Transcription regulator, SpoVT/AbrB family, containing PhoU domain. (304 aa) |
| | lysS | lysyl-tRNA synthetase. (526 aa) |
| | radB | RadB recombinase; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity). (220 aa) |
| | TK2229 | Transcription regulator, SpoVT/AbrB family. (74 aa) |
| | fau-1 | RNA-binding protein FAU-1; Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Preferentially cleaves UA sequences in the 5' precursor region of 5S rRNA. Binds to RNA in loop regions with AU-rich sequences (By similarity). Belongs to the FAU-1 family. (471 aa) |
| | rfcS | Replication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (866 aa) |
| | endA | Archaeal tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. (168 aa) |
| | mre11 | DNA repair exonuclease Rad32/Mre11 homolog; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (460 aa) |
| | TK2197 | Predicted transcription regulator, fused to C-terminal uncharacterized domain. (300 aa) |
| | TK2156 | RNA-binding protein, containing PUA domain. (568 aa) |
| | TK2151 | Archaeal transcription regulator; Putative transcriptional regulator. (151 aa) |
| | lig | ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Can also use NAD, but less efficiently than ATP; Belongs to the ATP-dependent DNA ligase family. (562 aa) |
| | TK2134 | Transcription regulator, Lrp/AsnC family. (141 aa) |
| | TK2122 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family, containing RNA-binding PUA domain; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (383 aa) |
| | TK2110 | Transcription regulator, Lrp/AsnC family. (150 aa) |
| | TK2097 | RNA-binding protein, containing THUMP domain. (160 aa) |
| | tfe | Transcription initiation factor IIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing [...] (185 aa) |
| | TK1997 | Hydrogenase maturation protein HypF. (772 aa) |
| | nac | Transcription factor, nascent polypeptide-associated complex alpha homolog; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. (111 aa) |
| | TK1970 | Probable tRNA/rRNA methyltransferase, SpoU family. (235 aa) |
| | TK1961 | Replication factor A complex, RPA41 subunit. (356 aa) |
| | TK1959 | Replication factor A complex, RPA32 subunit. (268 aa) |
| | TK1955 | Predicted transcription regulator, Lrp/AsnC family. (154 aa) |
| | eif2g | Translation initiation factor eIF-2, gamma subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (410 aa) |
| | TK1935 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (450 aa) |
| | TK1933 | Predicted DNA methylase. (209 aa) |
| | TK1932 | ATPase, RecA superfamily. (448 aa) |
| | TK1905 | Hypothetical protein, conserved. (323 aa) |
| | polC | DNA polymerase II, large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity). (1798 aa) |
| | polB | DNA polymerase II, small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (735 aa) |
| | cdc6 | Cell division control protein 6 homolog; Involved in regulation of DNA replication. (415 aa) |
| | radA | RadA/Rad51 recombinase; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity). (836 aa) |
| | nucS | Hypothetical protein, conserved, DUF91 family; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (252 aa) |
| | TK1865 | Predicted AP endonuclease. (271 aa) |
| | TK1863 | Predicted N6-adenine-specific DNA methylase. (365 aa) |
| | TK1842 | Probable transposase. (393 aa) |
| | TK1841 | Predicted site-specific integrase-resolvase. (202 aa) |
| | TK1821 | ATPase, PP-loop superfamily. (323 aa) |
| | TK1816 | Hypothetical protein, conserved, flame shift. (61 aa) |
| | TK1785 | Probable tRNA/rRNA methyltransferase. (396 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1065 aa) |
| | cca | tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (456 aa) |
| | TK1699 | DNA-directed RNA polymerase, subunit E'. (190 aa) |
| | TK1688 | Predicted transcription regulator, containing DNA-binding HTH domain. (243 aa) |
| | rrp4 | Exosome subunit Rrp4p homolog, RNA-binding protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. (257 aa) |
| | eif2b | Translation initiation factor eIF-2, beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (142 aa) |
| | TK1620 | DNA replication licensing factor, MCM2/3/5 family; Contains two inteins; Belongs to the MCM family. (1157 aa) |
| | TK1607 | alanyl-tRNA synthetase-related protein (C-terminus). (406 aa) |
| | TK1581 | Hypothetical protein, conserved, UPF0113 family. (169 aa) |
| | TK1574 | Histone acetyltransferase Elp3 homolog. (595 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (917 aa) |
| | TK1556 | ATPase, PP-loop superfamily. (304 aa) |
| | rpl3 | LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (346 aa) |
| | rpl4 | LSU ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (255 aa) |
| | rpl23 | LSU ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (86 aa) |
| | rpl2 | LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (239 aa) |
| | rps19 | SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (133 aa) |
| | rpl22 | LSU ribosomal protein L22P; This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (156 aa) |
| | rps3 | SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (209 aa) |
| | TK1534 | Protein translation factor SUI1 homolog; Belongs to the SUI1 family. (98 aa) |
| | rnp1 | Ribonuclease P component, Rpp29 homolog; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family. (125 aa) |
| | rps17 | SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (114 aa) |
| | rpl14 | LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (141 aa) |
| | rpl24 | LSU ribosomal protein L24P; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (121 aa) |
| | rps4e | SSU ribosomal protein S4E; Belongs to the eukaryotic ribosomal protein eS4 family. (243 aa) |
| | rpl5 | LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (183 aa) |
| | rps14 | SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (56 aa) |
| | rps8 | SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rpl6 | LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (184 aa) |
| | rpl19e | LSU ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (150 aa) |
| | rpl18 | LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (201 aa) |
| | rps5 | SSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (235 aa) |
| | rpl30 | LSU ribosomal protein L30P. (155 aa) |
| | rpl15 | LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (148 aa) |
| | rpl14e | LSU ribosomal protein L14E; Belongs to the eukaryotic ribosomal protein eL14 family. (83 aa) |
| | TK1510 | Hypothetical protein, conserved. (79 aa) |
| | truB | tRNA pseudouridine synthase B; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (338 aa) |
| | rps13 | SSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (149 aa) |
| | rps4 | SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (180 aa) |
| | rps11 | SSU ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (140 aa) |
| | rpoD | DNA-directed RNA polymerase, subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. (259 aa) |
| | rpl18e | LSU ribosomal protein L18E; Belongs to the eukaryotic ribosomal protein eL18 family. (121 aa) |
| | rpl13 | LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa) |
| | rps9 | SSU ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (135 aa) |
| | rpoN | DNA-directed RNA polymerase subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (65 aa) |
| | rpoK | DNA-directed RNA polymerase, subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (57 aa) |
| | TK1491 | Transcription regulator, Lrp/AsnC family. (149 aa) |
| | TK1489 | Adenine phosphoribosyltransferase, fused to N-terminal DNA-binding domain. (237 aa) |
| | srp54 | Signal recognition particle, SRP54 subunit; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (448 aa) |
| | rnj | Hydrolase, metallo-beta-lactamase superfamily; An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily. (444 aa) |
| | TK1460 | Predicted endonuclease-methyltransferase fusion protein. (1282 aa) |
| | rpl15e | LSU ribosomal protein L15E; Belongs to the eukaryotic ribosomal protein eL15 family. (194 aa) |
| | rnp3 | Ribonuclease P component, Rpp30 homolog; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family. (220 aa) |
| | TK1439 | Probable nickel responsive regulator; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (138 aa) |
| | TK1438 | Predicted fibronectin-binding protein. (650 aa) |
| | TK1428 | Cleavage and polyadenylation specficity factor subunit homolog. (648 aa) |
| | spt5 | Transcription antitermination protein; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (152 aa) |
| | rpl11 | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (165 aa) |
| | rpl1 | LSU ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (216 aa) |
| | rpl10 | LSU ribosomal protein L10E; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (340 aa) |
| | hpkA | Archaeal histone A; Binds and compacts DNA (about 120 base pairs per nucleosome, corresponding to four histone dimers) to form nucleosome-like structures. (67 aa) |
| | dnaG | DnaG-related protein, containing Toprim domain; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (464 aa) |
| | TK1386 | Metallophosphoesterase, calcineurin superfamily. (225 aa) |
| | TK1372 | Predicted transcription regulator, SpoVT/AbrB family. (61 aa) |
| | TK1361 | DNA replication licensing factor, MCM2/3/5 family; Belongs to the MCM family. (810 aa) |
| | TK1342 | Predicted integrase, C-fragment. (318 aa) |
| | TK1339 | Predicted transcription regulator, containing DNA-binding HTH domain. (65 aa) |
| | hel308 | RNA helicase Ski2 homolog; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (1125 aa) |
| | srp19 | Signal recognition particle, SRP19 subunit; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. (108 aa) |
| | rpl18a | LSU ribosomal protein L20A. (77 aa) |
| | eif6 | Translation initiation factor eIF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (229 aa) |
| | TK1315 | 3'-phosphoadenosine 5'-phosphosulfate reductase, fused to RNA-binding PUA and 4Fe-4S binding domains. (631 aa) |
| | TK1313 | Hypothetical protein, conserved. (203 aa) |
| | rpl7ae | LSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (125 aa) |
| | rpl24e | LSU ribosomal protein L24E; Binds to the 23S rRNA. (67 aa) |
| | infB | Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity). (1144 aa) |
| | TK1291 | Predicted transcription regulator, SpoVT/AbrB family. (75 aa) |
| | TK1285 | Transcription regulator, Lrp/AsnC family. (151 aa) |
| | fen | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] (340 aa) |
| | TK1278 | Double-stranded DNA-binding protein; Belongs to the PDCD5 family. (112 aa) |
| | rps19e | SSU ribosomal protein S19E; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (150 aa) |
| | TK1275 | Predicted RNA-binding protein, CRS1/YhbY family. (136 aa) |
| | ribK | Predicted transcription regulator, containing Crp and DUF120 domains; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (211 aa) |
| | TK1269 | Predicted phosphoesterase, DHH family, fused to NAD-binding TrkA-N domain. (487 aa) |
| | TK1266 | Predicted transcription regulator, containing CBS domains. (192 aa) |
| | TK1259 | Predicted transcription regulator, Lrp/AsnC family. (150 aa) |
| | TK1257 | RNA-binding protein, containing THUMP domain. (355 aa) |
| | TK1252 | ssDNA-specific exonuclease. (477 aa) |
| | rps15 | SSU ribosomal protein S15P. (151 aa) |
| | TK1242 | Hypothetical protein, conserved. (131 aa) |
| | prf1 | Peptide chain release factor eRF1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (415 aa) |
| | TK1210 | Transcription regulator, Lrp/AsnC family. (153 aa) |
| | TK1190 | Predicted GTPase, containing NOG1 domain. (358 aa) |
| | hjc | Archaeal type Holliday junction resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. (128 aa) |
| | thrS | Threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr); Belongs to the class-II aminoacyl-tRNA synthetase family. (626 aa) |
| | csl4 | RNA-binding protein, containing S1 domain; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. (198 aa) |
| | rpoL | DNA-directed RNA polymerase, subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. (94 aa) |
| | TK1158 | Predicted endonuclease-methyltransferase fusion protein. (1125 aa) |
| | TK1147 | Predicted type II restriction endonuclease. (710 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (246 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (455 aa) |
| | TK1112 | RNA-binding protein, containing KH domain. (60 aa) |
| | nop10 | RNA-binding protein, Nop10p family; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (59 aa) |
| | eif2a | Translation initiation factor eIF-2, alpha subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (275 aa) |
| | rps27e | SSU ribosomal protein S27E. (65 aa) |
| | rpl44e | LSU ribosomal protein L44E; Binds to the 23S rRNA. (94 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (1229 aa) |
| | rpoH | DNA-directed RNA polymerase, subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (82 aa) |
| | TK1083 | DNA-directed RNA polymerase, subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1123 aa) |
| | TK1082 | DNA-directed RNA polymerase, subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (906 aa) |
| | rpoA2 | DNA-directed RNA polymerase, subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (391 aa) |
| | rpl30e | LSU ribosomal protein L30E; Belongs to the eukaryotic ribosomal protein eL30 family. (102 aa) |
| | nusA | Transcription termination-antitermination factor, NusA homolog; Participates in transcription termination. Belongs to the NusA family. (145 aa) |
| | rps12 | SSU ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (147 aa) |
| | rps7 | SSU ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (215 aa) |
| | TK1076 | Transcription regulator, SpoVT/AbrB family. (81 aa) |
| | TK1069 | Hypothetical protein, conserved. (114 aa) |
| | TK1057 | iron(II) uptake regulation protein, frame shift. (82 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (741 aa) |
| | TK1047 | Translation initiation factor eIF-2B, delta subunit; Belongs to the eIF-2B alpha/beta/delta subunits family. (275 aa) |
| | TK1021 | Helicase-associated endonuclease for fork-structured DNA. (804 aa) |
| | smc | Chromosome segregation ATPase; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1189 aa) |
| | TK1015 | Large helicase-related protein. (925 aa) |
| | TK0997 | Transcription regulator, SpoVT/AbrB family. (91 aa) |
| | TK0984 | alanyl-tRNA synthetase-related protein (partial). (215 aa) |
| | TK0981 | N2, N2-dimethylguanosine tRNA methyltransferase. (331 aa) |
| | rpl37e | LSU ribosomal protein L37E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (63 aa) |
| | trm1 | N2,N2-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (376 aa) |
| | TK0956 | LexA-related DNA-binding protein. (88 aa) |
| | TK0953 | Predicted ATPase, AAA superfamily, containing PIN and KH nucleic acid-binding domains. (602 aa) |
| | TK0948 | Putative translation factor Sua5p homolog; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (339 aa) |
| | TK0932 | IS200-like transposase. (136 aa) |
| | TK0931 | Probable transposase. (391 aa) |
| | TK0928 | Predicted DNA/RNA repair helicase. (461 aa) |
| | truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. (267 aa) |
| | pheT | phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. (574 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha subunit. (501 aa) |
| | TK0907 | DNA-binding protein translin homolog. (206 aa) |
| | nfi | Endonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (197 aa) |
| | pus10 | RNA-binding protein, containing THUMP domain; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. (393 aa) |
| | rsmA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (279 aa) |
| | TK0888 | Transcription regulator, SpoVT/AbrB family. (80 aa) |
| | eif5a | Translation initiation factor eIF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (136 aa) |
| | nep1 | Ribosome biogenesis protein Nep1p homolog, suppressor Mra1 family; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. (220 aa) |
| | TK0872 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (309 aa) |
| | TK0855 | Hypothetical protein, conserved. (312 aa) |
| | TK0850 | Probable transposase. (431 aa) |
| | TK0834 | Transcription regulator, Lrp/AsnC family. (192 aa) |
| | rnhB | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (228 aa) |
| | eif1a | Translation initiation factor eIF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (117 aa) |
| | TK0800 | RNA-binding protein, containing KH domain. (238 aa) |
| | top6B | Type II DNA topoisomerase VI, subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (567 aa) |
| | top6A | Type II DNA topoisomerase VI, subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (385 aa) |
| | TK0796 | DNA-binding protein, containing HTH domain of resolvase. (139 aa) |
| | TK0784 | ERCC2/XPD/Rad3-related DNA repair helicase. (637 aa) |
| | sfsA | Sugar fermentation stimulation protein; Belongs to the SfsA family. (237 aa) |
| | xerA | Integrase/recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Belongs to the 'phage' integrase family. XerA subfamily. (282 aa) |
| | TK0773 | Predicted ATP-dependent endonuclease, OLD family. (648 aa) |
| | TK0764 | Large helicase-related protein; Contains an intein. (1390 aa) |
| | tgtA | Archaeosine tRNA-guanine transglycosylase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (580 aa) |
| | asnS | asparaginyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (431 aa) |
| | tmcA | Predicted ATPase, DUF699 family, fused to acetyltransferase domain; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (811 aa) |
| | TK0697 | Predicted transcription regulator, containing DNA-binding HTH domain. (219 aa) |
| | mutS2 | MutS-like DNA mismatch repair ATPase; Has ATPase and non-specific DNA-binding activities. Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily. (576 aa) |
| | TK0655 | Predicted site-specific integrase/resolvase. (209 aa) |
| | TK0654 | Probable transposase. (417 aa) |
| | TK0649 | Putative tRNA-binding protein. (241 aa) |
| | TK0645 | Predicted phosphohydrolase, DHH family. (327 aa) |
| | TK0617 | U3 snoRNP component, archaeal imp4 homolog, containing Brix domain; Probably involved in the biogenesis of the ribosome. (208 aa) |
| | rpoP | DNA-directed RNA polymerase, subunit P; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (49 aa) |
| | rpl37ae | LSU ribosomal protein L37AE. (86 aa) |
| | TK0614 | SSV1 integrase homolog, C-fragment. (317 aa) |
| | TK0588 | Predicted transcription regulator, SpoVT/AbrB family. (140 aa) |
| | pcn2 | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. (253 aa) |
| | TK0567 | Transcription regulator, Lrp/AsnC family. (166 aa) |
| | TK0566 | DEAD/DEAH box RNA helicase. (832 aa) |
| | albA | Archaeal chromatin protein, Alba; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes (By similarity). Incubation with DNA in vitro gives fibrous structures 10.3 +/- 1.1 nm in thickness (naked DNA is 1.83 +/- 0.37 nm). This protein does not significantly compact DNA ; Belongs to the histone-like Alba family. (91 aa) |
| | TK0556 | Translation initiation factor eIF-2B, beta subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (356 aa) |
| | tiaS | Nucleic acid-binding protein, containing OB-fold domain; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. (424 aa) |
| | TK0539 | Predicted transcription regulator, containing DNA-binding HTH domain. (318 aa) |
| | pcn1 | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. (249 aa) |
| | TK0533 | Archaeal transcription factor S; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (110 aa) |
| | TK0521 | DEAD/DEAH box RNA helicase, fused to C-terminal uncharacterized domain. (900 aa) |
| | TK0508 | Predicted transcription regulator, Lrp/AsnC family. (160 aa) |
| | TK0495 | Probable transposase. (420 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Is specific for tRNA(Asp) since it aspartylates tRNA(Asn) 3 orders of magnitude less efficiently than tRNA(Asp); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. (438 aa) |
| | TK0481 | RNA-binding protein, containing KH domain. (170 aa) |
| | trmBL2 | Probable transcription regulator, DUF118 helix-turn-helix family; An abundant chromosomal protein that seems to be involved in both genome architecture and transcription repression. Incubation with DNA in vitro gives fibrous structures 14.2 +/- 2.1 nm in thickness (naked DNA is 1.83 +/- 0.37 nm); does not significantly compact DNA. Binds to both coding and non-coding regions; binding within gene promoters correlates with decreased transcript levels, while binding within coding regions does not. (264 aa) |
| | rgy | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity); In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily. (1711 aa) |
| | TK0460 | DEAD/DEAH box helicase, fused to N-terminal HD domain. (740 aa) |
| | TK0457 | Transcription regulator, SpoVT/AbrB family. (75 aa) |
| | cas1 | Hypothetical protein, conserved, DUF48 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (326 aa) |
| | TK0450 | DEAD/DEAH box helicase. (533 aa) |
| | TK0448 | Predicted transcription regulator, containing DNA-binding HTH domain. (225 aa) |
| | TK0409 | Predicted transcription regulator, SpoVT/AbrB family. (145 aa) |
| | TK0406 | Predicted transcription regulator, SpoVT/AbrB family. (141 aa) |
| | TK0405 | Predicted transcription regulator, SpoVT/AbrB family. (139 aa) |
| | TK0381 | SSV1 integrase homolog, C-fragment. (287 aa) |
| | TK0371 | Hypothetical protein. (93 aa) |
| | thiI | Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (381 aa) |
| | TK0360 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (312 aa) |
| | TK0345 | 3-methyladenine DNA glycosylase. (280 aa) |
| | TK0341 | Nucleotidyltransferase, fused to N-terminal DNA-binding domain. (202 aa) |
| | fusA | Translation elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF- [...] (732 aa) |
| | tuf | Translation elongation factor EF-1, alpha subunit; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (428 aa) |
| | rps10 | SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa) |
| | TK0306 | DEAD/DEAH box RNA helicase; Belongs to the DEAD box helicase family. (406 aa) |
| | TK0298 | Probable transposase. (431 aa) |
| | TK0239 | Putative tRNA-binding protein. (109 aa) |
| | TK0184 | snoRNP component, Nop56p/58p homolog. (420 aa) |
| | flpA | snoRNP component, Fibrillarin homolog; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (226 aa) |
| | TK0178 | DNA helicase, UvrD/REP family. (661 aa) |
| | TK0170 | Endonuclease IV. (281 aa) |
| | TK0169 | Predicted transcription regulator, MarR family; Belongs to the GbsR family. (182 aa) |
| | TK0155 | RecJ-like exonuclease, containing OB-fold nucleic acid-binding domains. (741 aa) |
| | TK0142 | Predicted transcription regulator, containing cell wall binding repeat 2 and DNA-binding HTH domains. (334 aa) |
| | tbp | Transcription initiation factor TFIID; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (190 aa) |
| | TK0126 | Predicted transcription regulator, containing DNA-binding HTH domain. (180 aa) |
| | ef1b | Translation elongation factor EF-1, beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (91 aa) |
| | TK0107 | Manganese-dependent transcription regulator. (147 aa) |
| | TK0104 | Probable integrase/recombinase. (172 aa) |
| | TK0096 | DNA replication licensing factor, MCM2/3/5 family; Belongs to the MCM family. (914 aa) |
| | TK0094 | Transcription regulator, SpoVT/AbrB family. (125 aa) |
| | TK0073 | SSV1 integrase homolog, C-fragment. (297 aa) |
| | TK0063 | Nucleotidyltransferase, fused to N-terminal DNA-binding domain. (182 aa) |
| | TK0017 | Predicted transcription regulator, SpoVT/AbrB family. (71 aa) |
| | pol | DNA-directed DNA polymerase, family B; Intein encoded endonucleases are thought to mediate intein mobility by site-specific recombination initiated by endonuclease cleavage at the 'homing site' in gene that lack the intein. PI-PkoI recognizes 5'-GATTTAGATCCCTGTACC-3' and PI-PkoII recognizes 5'- CAGCTACTACGGTTAC-3'. (1671 aa) |
