STRINGSTRING
TK0059 TK0059 TK0181 TK0181 TK0303 TK0303 egsA egsA TK0914 TK0914 TK1026 TK1026 TK1088 TK1088 uppS uppS pckG pckG idsA idsA fni fni TK1473 TK1473 mvk mvk TK1670 TK1670 TK1690 TK1690 TK1716 TK1716 TK1720 TK1720 TK1909 TK1909 TK1957 TK1957 carS carS TK2278 TK2278 TK2279 TK2279
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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TK0059CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (189 aa)
TK01813-hydroxy-3-methylglutaryl-CoA synthase; Belongs to the thiolase-like superfamily. UPF0219 family. (350 aa)
TK0303Membrane-bound metal-dependent hydrolase. (583 aa)
egsAGlycerol-1-phosphate dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family. (351 aa)
TK09143-hydroxy-3-methylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family. (408 aa)
TK1026Geranylgeranylglyceryl diphosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids; Belongs to the GGGP/HepGP synthase family. Group II subfamily. (252 aa)
TK1088Geranylgeranyl hydrogenase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (395 aa)
uppSUndecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids. (264 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (623 aa)
idsABifunctional short-chain isoprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (343 aa)
fniIsopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (374 aa)
TK1473Amino acid kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. (262 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (337 aa)
TK1670Hypothetical protein, conserved. (745 aa)
TK1690Hypothetical membrane protein, conserved. (584 aa)
TK1716Cytidylyltransferase. (229 aa)
TK1720Dolichol-phosphate mannosyltransferase. (241 aa)
TK1909Dolichol-phosphate mannosyltransferase, fused to membrane-bound GtrA-like domain. (352 aa)
TK19574-hydroxybenzoate octaprenyltransferase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (277 aa)
carSHypothetical membrane protein, conserved, DUF46 family; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (171 aa)
TK2278Myo-inositol-1-phosphate synthase. (382 aa)
TK2279Bifunctional sugar nucleotidyltransferase/CDP-alcohol phosphatidyltransferase synthase; Involved in biosynthesis of di-myo-inositol phosphate (DIP), a widespread organic solute in microorganisms adapted to hot environments. Catalyzes the condensation of CTP and L-myo-inositol-1- phosphate into CDP-L-myo-inositol, as well as the biosynthesis of di- myo-inositol-1,3'-phosphate-1'-phosphate (DIPP) from CDP-L-myo-inositol and L-myo-inositol-1-phosphate; In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family. (432 aa)
Your Current Organism:
Thermococcus kodakarensis
NCBI taxonomy Id: 69014
Other names: Pyrococcus sp. (strain KOD1), Pyrococcus sp. KOD1, T. kodakarensis KOD1, Thermococcus kodakaraensis KOD1, Thermococcus kodakarensis KOD1, Thermococcus kodakarensis str. KOD1, Thermococcus kodakarensis strain KOD1
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