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| | fau-1 | RNA-binding protein FAU-1; Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Preferentially cleaves UA sequences in the 5' precursor region of 5S rRNA. Binds to RNA in loop regions with AU-rich sequences (By similarity). Belongs to the FAU-1 family. (471 aa) |
| | lysS | lysyl-tRNA synthetase. (526 aa) |
| | TK2250 | Serine/threonine protein kinase, RIO1 family. (311 aa) |
| | TK2275 | RNA-binding protein, containing PUA domain. (172 aa) |
| | TK2277 | Hypothetical protein, conserved. (200 aa) |
| | tfb2 | Transcription initiation factor IIB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (306 aa) |
| | TK1083 | DNA-directed RNA polymerase, subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1123 aa) |
| | rpoH | DNA-directed RNA polymerase, subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (82 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (1229 aa) |
| | rpl44e | LSU ribosomal protein L44E; Binds to the 23S rRNA. (94 aa) |
| | rps27e | SSU ribosomal protein S27E. (65 aa) |
| | eif2a | Translation initiation factor eIF-2, alpha subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (275 aa) |
| | nop10 | RNA-binding protein, Nop10p family; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (59 aa) |
| | rnz | Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (314 aa) |
| | TK1116 | 23S rRNA (uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (421 aa) |
| | TK1135 | Hypothetical protein, conserved, radical SAM superfamily. (324 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (455 aa) |
| | TK1166 | Hypothetical protein, conserved. (133 aa) |
| | rpoL | DNA-directed RNA polymerase, subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. (94 aa) |
| | csl4 | RNA-binding protein, containing S1 domain; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. (198 aa) |
| | thrS | Threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr); Belongs to the class-II aminoacyl-tRNA synthetase family. (626 aa) |
| | map | Methionyl aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. (295 aa) |
| | rps8e | SSU ribosomal protein S8E. (130 aa) |
| | TK1234 | Lipoate-protein ligase A, C-terminal section. (92 aa) |
| | argS | arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (642 aa) |
| | prf1 | Peptide chain release factor eRF1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (415 aa) |
| | rps15 | SSU ribosomal protein S15P. (151 aa) |
| | rps3ae | SSU ribosomal protein S3AE; Belongs to the eukaryotic ribosomal protein eS1 family. (200 aa) |
| | TK1257 | RNA-binding protein, containing THUMP domain. (355 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (888 aa) |
| | rps19e | SSU ribosomal protein S19E; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (150 aa) |
| | tfb1 | Transcription initiation factor IIB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (300 aa) |
| | TK1286 | Predicted GTPase, GTP1/OBG family, containing TGS domain. (388 aa) |
| | infB | Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity). (1144 aa) |
| | rpl24e | LSU ribosomal protein L24E; Binds to the 23S rRNA. (67 aa) |
| | rps28e | SSU ribosomal protein S28E; Belongs to the eukaryotic ribosomal protein eS28 family. (70 aa) |
| | rpl7ae | LSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (125 aa) |
| | TK1313 | Hypothetical protein, conserved. (203 aa) |
| | rpl39e | LSU ribosomal protein L39E; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa) |
| | rpl31e | LSU ribosomal protein L31E; Belongs to the eukaryotic ribosomal protein eL31 family. (90 aa) |
| | eif6 | Translation initiation factor eIF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (229 aa) |
| | rpl18a | LSU ribosomal protein L20A. (77 aa) |
| | TK1328 | tRNA (1-methyladenosine) methyltransferase. (253 aa) |
| | hel308 | RNA helicase Ski2 homolog; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (1125 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (573 aa) |
| | rpl12 | LSU ribosomal protein L12A; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (106 aa) |
| | rpl10 | LSU ribosomal protein L10E; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (340 aa) |
| | rpl1 | LSU ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (216 aa) |
| | rpl11 | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (165 aa) |
| | spt5 | Transcription antitermination protein; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (152 aa) |
| | TK1425 | Hypothetical protein, conserved; RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. Belongs to the HARP family. (198 aa) |
| | TK1438 | Predicted fibronectin-binding protein. (650 aa) |
| | rnp3 | Ribonuclease P component, Rpp30 homolog; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family. (220 aa) |
| | rpl15e | LSU ribosomal protein L15E; Belongs to the eukaryotic ribosomal protein eL15 family. (194 aa) |
| | leuS | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (967 aa) |
| | rpl40e | LSU ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. (51 aa) |
| | rps2 | SSU ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family. (201 aa) |
| | rpoK | DNA-directed RNA polymerase, subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (57 aa) |
| | rpoN | DNA-directed RNA polymerase subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (65 aa) |
| | rps9 | SSU ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (135 aa) |
| | rpl13 | LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa) |
| | rpl18e | LSU ribosomal protein L18E; Belongs to the eukaryotic ribosomal protein eL18 family. (121 aa) |
| | rpoD | DNA-directed RNA polymerase, subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. (259 aa) |
| | rps11 | SSU ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (140 aa) |
| | rps4 | SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (180 aa) |
| | rps13 | SSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (149 aa) |
| | truB | tRNA pseudouridine synthase B; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (338 aa) |
| | rpl14e | LSU ribosomal protein L14E; Belongs to the eukaryotic ribosomal protein eL14 family. (83 aa) |
| | rpl34e | LSU ribosomal protein L34E; Belongs to the eukaryotic ribosomal protein eL34 family. (90 aa) |
| | rpl15 | LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (148 aa) |
| | rpl30 | LSU ribosomal protein L30P. (155 aa) |
| | rps5 | SSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (235 aa) |
| | rpl18 | LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (201 aa) |
| | rpl19e | LSU ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (150 aa) |
| | rpl32e | LSU ribosomal protein L32E; Belongs to the eukaryotic ribosomal protein eL32 family. (126 aa) |
| | rpl6 | LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (184 aa) |
| | rps8 | SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rps14 | SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (56 aa) |
| | rpl5 | LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (183 aa) |
| | rps4e | SSU ribosomal protein S4E; Belongs to the eukaryotic ribosomal protein eS4 family. (243 aa) |
| | rpl24 | LSU ribosomal protein L24P; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (121 aa) |
| | rpl14 | LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (141 aa) |
| | rps17 | SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (114 aa) |
| | rnp1 | Ribonuclease P component, Rpp29 homolog; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family. (125 aa) |
| | TK1534 | Protein translation factor SUI1 homolog; Belongs to the SUI1 family. (98 aa) |
| | rpl29 | LSU ribosomal protein L29P; Belongs to the universal ribosomal protein uL29 family. (66 aa) |
| | rps3 | SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (209 aa) |
| | rpl22 | LSU ribosomal protein L22P; This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (156 aa) |
| | rps19 | SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (133 aa) |
| | rpl2 | LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (239 aa) |
| | rpl23 | LSU ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (86 aa) |
| | rpl4 | LSU ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (255 aa) |
| | rpl3 | LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (346 aa) |
| | rpl10e | LSU ribosomal protein L10E; Belongs to the universal ribosomal protein uL16 family. (182 aa) |
| | TK1550 | asparaginyl-tRNA synthetase-related protein (N-truncation). (299 aa) |
| | TK1551 | Predicted ATPase, PP-loop superfamily. (276 aa) |
| | TK1556 | ATPase, PP-loop superfamily. (304 aa) |
| | hisS | histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (436 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (917 aa) |
| | TK1574 | Histone acetyltransferase Elp3 homolog. (595 aa) |
| | TK1607 | alanyl-tRNA synthetase-related protein (C-terminus). (406 aa) |
| | rtcA | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity). (343 aa) |
| | TK1620 | DNA replication licensing factor, MCM2/3/5 family; Contains two inteins; Belongs to the MCM family. (1157 aa) |
| | eif2b | Translation initiation factor eIF-2, beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (142 aa) |
| | rrp4 | Exosome subunit Rrp4p homolog, RNA-binding protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. (257 aa) |
| | taw1 | Hypothetical protein, conserved, radical SAM superfamily; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (333 aa) |
| | rps27ae | SSU ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family. (57 aa) |
| | rps24e | SSU ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family. (98 aa) |
| | TK1699 | DNA-directed RNA polymerase, subunit E'. (190 aa) |
| | TK1703 | Signal peptidase I, fused to C-terminal uncharacterized domain. (355 aa) |
| | hpkB | Archaeal histone B; Binds and compacts DNA (about 120 base pairs per nucleosome, corresponding to four histone dimers) to form nucleosome-like structures. (67 aa) |
| | rps17e | SSU ribosomal protein S17E; Belongs to the eukaryotic ribosomal protein eS17 family. (67 aa) |
| | pth | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. (118 aa) |
| | truD | tRNA pseudouridine synthase D; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (416 aa) |
| | pol | DNA-directed DNA polymerase, family B; Intein encoded endonucleases are thought to mediate intein mobility by site-specific recombination initiated by endonuclease cleavage at the 'homing site' in gene that lack the intein. PI-PkoI recognizes 5'-GATTTAGATCCCTGTACC-3' and PI-PkoII recognizes 5'- CAGCTACTACGGTTAC-3'. (1671 aa) |
| | TK0008 | Predicted DNA methylase. (366 aa) |
| | rnp4 | Ribonuclease P component, Rpp21 homolog; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (132 aa) |
| | TK0060 | Hypothetical protein, conserved, DUF127 family; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. (180 aa) |
| | taw2 | Met-10+ like protein; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). (278 aa) |
| | ef1b | Translation elongation factor EF-1, beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (91 aa) |
| | tbp | Transcription initiation factor TFIID; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (190 aa) |
| | gcvH | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (134 aa) |
| | taw3-1 | Hypothetical protein, conserved, DUF207 family; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. (198 aa) |
| | flpA | snoRNP component, Fibrillarin homolog; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (226 aa) |
| | TK0239 | Putative tRNA-binding protein. (109 aa) |
| | TK0242 | ATP phosphoribosyltransferase, predicted regulatory subunit. (293 aa) |
| | rpl21e | LSU ribosomal protein L21E; Belongs to the eukaryotic ribosomal protein eL21 family. (98 aa) |
| | pus10 | RNA-binding protein, containing THUMP domain; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. (393 aa) |
| | gatD | Archaeal Glu-tRNA(Gln) amidotransferase, subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (440 aa) |
| | gatE | Archaeal Glu-tRNA(Gln) amidotransferase, subunit E containing GAD domain; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (629 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha subunit. (501 aa) |
| | pheT | phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. (574 aa) |
| | truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. (267 aa) |
| | TK0948 | Putative translation factor Sua5p homolog; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (339 aa) |
| | TK0960 | Predicted ATPase, PP-loop superfamily. (272 aa) |
| | rpl35ae | LSU ribosomal protein L35AE; Belongs to the eukaryotic ribosomal protein eL33 family. (86 aa) |
| | trm1 | N2,N2-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (376 aa) |
| | rpl37e | LSU ribosomal protein L37E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (63 aa) |
| | glyS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). (570 aa) |
| | TK0981 | N2, N2-dimethylguanosine tRNA methyltransferase. (331 aa) |
| | TK0984 | alanyl-tRNA synthetase-related protein (partial). (215 aa) |
| | TK1031 | Predicted ATPase, RNase L inhibitor homolog. (594 aa) |
| | TK1032 | Hydrogenase expression/formation protein HypE. (330 aa) |
| | TK1047 | Translation initiation factor eIF-2B, delta subunit; Belongs to the eIF-2B alpha/beta/delta subunits family. (275 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (741 aa) |
| | rps7 | SSU ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (215 aa) |
| | rps12 | SSU ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (147 aa) |
| | nusA | Transcription termination-antitermination factor, NusA homolog; Participates in transcription termination. Belongs to the NusA family. (145 aa) |
| | rpl30e | LSU ribosomal protein L30E; Belongs to the eukaryotic ribosomal protein eL30 family. (102 aa) |
| | rpoA2 | DNA-directed RNA polymerase, subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (391 aa) |
| | kptA | RNA 2'-phosphotransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase. (180 aa) |
| | rps10 | SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa) |
| | tuf | Translation elongation factor EF-1, alpha subunit; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (428 aa) |
| | fusA | Translation elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF- [...] (732 aa) |
| | TK1082 | DNA-directed RNA polymerase, subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (906 aa) |
| | TK0337 | Predicted nucleic acid-binding protein, containing PIN domain and zinc-ribbon module. (178 aa) |
| | rtcB | RNA terminal phosphate cyclase operon orfB homolog, UPF0027 family; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends; Belongs to the RtcB family. (482 aa) |
| | TK0360 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (312 aa) |
| | TK0361 | Hypothetical protein, conserved, DUF101 family; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity). (142 aa) |
| | TK0366 | ThiI-related protein. (191 aa) |
| | thiI | Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (381 aa) |
| | TK0422 | tRNA m1G methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of either N(1)-methyladenine or N(1)-methylguanine at position 9 (m1A9 or m1G9) in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family. (370 aa) |
| | TK0439 | Membrane-associated metalloprotease, CaaX family. (195 aa) |
| | cysS | cysteinyl-tRNA synthetase. (476 aa) |
| | rgy | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity); In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily. (1711 aa) |
| | TK0473 | Hypothetical protein, conserved, UPF0148 family. (111 aa) |
| | TK0481 | RNA-binding protein, containing KH domain. (170 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Is specific for tRNA(Asp) since it aspartylates tRNA(Asn) 3 orders of magnitude less efficiently than tRNA(Asp); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. (438 aa) |
| | TK0497 | Met-10+ like protein. (331 aa) |
| | TK0533 | Archaeal transcription factor S; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (110 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (481 aa) |
| | tiaS | Nucleic acid-binding protein, containing OB-fold domain; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. (424 aa) |
| | trmY | Hypothetical protein, conserved, DUF358 family; Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs; Belongs to the methyltransferase superfamily. TrmY family. (198 aa) |
| | TK0556 | Translation initiation factor eIF-2B, beta subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (356 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily. (375 aa) |
| | rpl37ae | LSU ribosomal protein L37AE. (86 aa) |
| | rpoP | DNA-directed RNA polymerase, subunit P; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (49 aa) |
| | TK0617 | U3 snoRNP component, archaeal imp4 homolog, containing Brix domain; Probably involved in the biogenesis of the ribosome. (208 aa) |
| | TK0649 | Putative tRNA-binding protein. (241 aa) |
| | dys | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. (337 aa) |
| | TK0679 | Serine/threonine protein kinase, RIO1 family. (221 aa) |
| | tmcA | Predicted ATPase, DUF699 family, fused to acetyltransferase domain; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (811 aa) |
| | asnS | asparaginyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (431 aa) |
| | tgtA | Archaeosine tRNA-guanine transglycosylase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (580 aa) |
| | TK0764 | Large helicase-related protein; Contains an intein. (1390 aa) |
| | eif1a | Translation initiation factor eIF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (117 aa) |
| | TK0807 | Hypothetical protein, conserved. (383 aa) |
| | TK0872 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (309 aa) |
| | nep1 | Ribosome biogenesis protein Nep1p homolog, suppressor Mra1 family; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. (220 aa) |
| | eif5a | Translation initiation factor eIF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (136 aa) |
| | rsmA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (279 aa) |
| | TK0901 | DNA-directed RNA polymerase, subunit F. (115 aa) |
| | TK1736 | Ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1746 aa) |
| | cca | tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (456 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1065 aa) |
| | rnp2 | Ribonuclease P component, Rpp14 homolog; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family. (120 aa) |
| | TK1784 | Predicted SAM-dependent methyltransferase, DUF890 family. (248 aa) |
| | TK1821 | ATPase, PP-loop superfamily. (323 aa) |
| | TK1853 | Type II/IV secretion system ATPase; Contains an intein. (1198 aa) |
| | TK1863 | Predicted N6-adenine-specific DNA methylase. (365 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (384 aa) |
| | radA | RadA/Rad51 recombinase; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity). (836 aa) |
| | polC | DNA polymerase II, large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity). (1798 aa) |
| | taw3-2 | Hypothetical protein, conserved, DUF207 family; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. (212 aa) |
| | TK1935 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (450 aa) |
| | eif2g | Translation initiation factor eIF-2, gamma subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (410 aa) |
| | rps6e | SSU ribosomal protein S6E; Belongs to the eukaryotic ribosomal protein eS6 family. (125 aa) |
| | TK1956 | Hypothetical protein, conserved, containing ATP/GTP-binding site motif A; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA (By similarity). (351 aa) |
| | TK1970 | Probable tRNA/rRNA methyltransferase, SpoU family. (235 aa) |
| | TK1993 | Hydrogenase expression/formation protein HypE. (338 aa) |
| | TK1997 | Hydrogenase maturation protein HypF. (772 aa) |
| | Tk-hypD | Hydrogenase expression/formation protein hypD. (372 aa) |
| | Tk-hypC | Hydrogenase expression/formation protein HypC. (75 aa) |
| | TK2004 | Hydrogenase maturation protease HycI. (158 aa) |
| | hypA | Hydrogenase nickel-incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Belongs to the HypA/HybF family. (139 aa) |
| | tfe | Transcription initiation factor IIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing [...] (185 aa) |
| | TK2037 | Signal peptidase I. (164 aa) |
| | TK2064 | Probable 2-methylthioadenine synthetase. (427 aa) |
| | frxA | Hydrogenase-specific maturation endopeptidase. (148 aa) |
| | TK2097 | RNA-binding protein, containing THUMP domain. (160 aa) |
| | TK2122 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family, containing RNA-binding PUA domain; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (383 aa) |
| | kae1 | O-Sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (325 aa) |
| | TK2135 | 23S rRNA (uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (417 aa) |
| | TK2151 | Archaeal transcription regulator; Putative transcriptional regulator. (151 aa) |
| | TK2156 | RNA-binding protein, containing PUA domain. (568 aa) |
| | TK2214 | Ribosomal protein-alanine acetyltransferase RimI homolog. (166 aa) |
| | endA | Archaeal tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. (168 aa) |
| | rfcS | Replication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (866 aa) |
| | TK2223 | Met-10+ like protein. (337 aa) |
