STRINGSTRING
TK1893 TK1893 TK1956 TK1956 TK2029 TK2029 eno eno nadK nadK tpiA tpiA TK2141 TK2141 cpkA cpkA TK2192 TK2192 prs prs TK2242 TK2242 TK2250 TK2250 TK2285 TK2285 TK0153 TK0153 TK0200 TK0200 aroK aroK lysZ lysZ mptE mptE pyrH pyrH TK0329 TK0329 TK0338 TK0338 pfkC pfkC serK serK TK0435 TK0435 pyk pyk TK0634 TK0634 TK0635 TK0635 TK0679 TK0679 gap gap TK0801 TK0801 adk adk apgM apgM thiL thiL TK0939 TK0939 fba fba pgk2 pgk2 glkA glkA pgiA pgiA pgk pgk ribK ribK TK1292 TK1292 TK1301 TK1301 ndk ndk tdk tdk glpK glpK tmk tmk thrB thrB TK1445 TK1445 TK1473 TK1473 mvk mvk TK1497 TK1497 cmk cmk adkA adkA TK1697 TK1697 galK galK TK1843 TK1843 nnrE nnrE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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TK1893Glycerate kinase-related protein, containing MOFRL domain (C-terminus). (248 aa)
TK1956Hypothetical protein, conserved, containing ATP/GTP-binding site motif A; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA (By similarity). (351 aa)
TK2029Carbohydrate/pyrimidine kinase, PfkB family; Involved in nucleoside degradation. Phosphorylates ribose 1- phosphate (R1P) to ribose 1,5-bisphosphate. Can also act on deoxyribose 1-phosphate (dR1P), but is most active with R1P. ADP is the most preferred phosphate donor, followed by GDP and UDP. Belongs to the carbohydrate kinase PfkB family. (294 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
nadKATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (278 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (226 aa)
TK2141GHMP kinase; Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. Displays broad nucleotide specificity and utilizes ATP, GTP, UTP, and CTP with comparable catalytic efficiencies. (300 aa)
cpkACarbamate kinase-like carbamoyl phosphate synthetase. (315 aa)
TK2192dephospho-CoA kinase. (195 aa)
prsPhosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). It can also use CTP and GTP as substrates in addition to ATP. (280 aa)
TK2242GHMP kinase; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P). (318 aa)
TK2250Serine/threonine protein kinase, RIO1 family. (311 aa)
TK2285Carbohydrate/pyrimidine kinase, PfkB family. (273 aa)
TK0153ATP:dephospho-CoA triphosphoribosyl transferase. (308 aa)
TK0200Phosphoenolpyruvate synthetase-related protein. (498 aa)
aroKArchaeal shikimate kinase. (271 aa)
lysZN2-acetyl-aminoadipate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (251 aa)
mptEHypothetical protein, conserved, DUF115 family; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (231 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (225 aa)
TK0329Lysine/arginine/ornithine transport system kinase. (319 aa)
TK0338Predicted nucleotide kinase, related to CMP and AMP kinases; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (177 aa)
pfkCADP-dependent phosphofructokinase; Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor. (461 aa)
serKChromosome partitioning protein ParB homolog; Free serine kinase that uses ADP to phosphorylate L-serine to yield O-phospho-L-serine and AMP. (242 aa)
TK0435Phosphomethylpyrimidine kinase, fused to C-terminal uncharacterized domain. (431 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (478 aa)
TK0634Chemotaxis histidine kinase, flame shift. (548 aa)
TK0635Chemotaxis histidine kinase, flame shift. (231 aa)
TK0679Serine/threonine protein kinase, RIO1 family. (221 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase (phosphorylating). (334 aa)
TK0801Serine/threonine protein kinase Rio1p homolog. (258 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (224 aa)
apgM2,3-Bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (411 aa)
thiLThiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (309 aa)
TK0939GHMP kinase; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P). (324 aa)
fbaDhnA-type fructose-1,6-bisphosphate aldolase; Belongs to the DeoC/FbaB aldolase family. (281 aa)
pgk22-phosphoglycerate kinase. (290 aa)
glkAADP-dependent glucokinase; Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate. Involved in chitin degradation. (453 aa)
pgiAArchaeal glucose-6-phosphate isomerase; Belongs to the archaeal-type GPI family. (189 aa)
pgk3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (411 aa)
ribKPredicted transcription regulator, containing Crp and DUF120 domains; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (211 aa)
TK1292Phosphoenolpyruvate synthetase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (793 aa)
TK1301Probable ATP-NAD kinase. (381 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (174 aa)
tdkThymidine kinase. (197 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. Can utilize other nucleoside triphosphates (GTP, CTP, UTP AND ITP) as a phosphoryl donor; Belongs to the FGGY kinase family. (497 aa)
tmkThymidylate kinase. (205 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (292 aa)
TK1445Aspartokinase. (366 aa)
TK1473Amino acid kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. (262 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (337 aa)
TK1497Enolase-related protein. (341 aa)
cmkCytidylate kinase. (193 aa)
adkAArchaeal adenylate kinase; Belongs to the archaeal adenylate kinase family. (196 aa)
TK1697Hypothetical protein, conserved, DUF359 family; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). Can also use UTP, with lower efficiency and has weak activity with ATP, but shows a strong preference for GTP as the phosphate donor. (177 aa)
galKGalactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (350 aa)
TK1843Carbohydrate/pyrimidine kinase, PfkB family; Involved in nucleoside degradation. Phosphorylates cytidine to CMP. Can also act on deoxycytidine and uridine, but is most active with cytidine. ATP is the most preferred phosphate donor, but it can also use GTP, CTP or UTP; Belongs to the carbohydrate kinase PfkB family. (278 aa)
nnrEYjeF-ralted probable carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow th [...] (480 aa)
Your Current Organism:
Thermococcus kodakarensis
NCBI taxonomy Id: 69014
Other names: Pyrococcus sp. (strain KOD1), Pyrococcus sp. KOD1, T. kodakarensis KOD1, Thermococcus kodakaraensis KOD1, Thermococcus kodakarensis KOD1, Thermococcus kodakarensis str. KOD1, Thermococcus kodakarensis strain KOD1
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