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| | hjc | Archaeal type Holliday junction resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. (128 aa) |
| | csl4 | RNA-binding protein, containing S1 domain; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. (198 aa) |
| | rpoL | DNA-directed RNA polymerase, subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. (94 aa) |
| | TK1155 | Small heat shock protein; Belongs to the small heat shock protein (HSP20) family. (164 aa) |
| | TK1145 | ABC-type multidrug transport system, permease component. (256 aa) |
| | TK1122 | Prefoldin, beta subunit. (112 aa) |
| | pfdA2 | Prefoldin, alpha subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. (142 aa) |
| | TK1105 | ABC-type cobalt transport system, CbiQ permease component. (219 aa) |
| | nop10 | RNA-binding protein, Nop10p family; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (59 aa) |
| | eif2a | Translation initiation factor eIF-2, alpha subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (275 aa) |
| | rps27e | SSU ribosomal protein S27E. (65 aa) |
| | rpoH | DNA-directed RNA polymerase, subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (82 aa) |
| | TK1083 | DNA-directed RNA polymerase, subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1123 aa) |
| | TK1082 | DNA-directed RNA polymerase, subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (906 aa) |
| | rpoA2 | DNA-directed RNA polymerase, subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (391 aa) |
| | rpl30e | LSU ribosomal protein L30E; Belongs to the eukaryotic ribosomal protein eL30 family. (102 aa) |
| | rps12 | SSU ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (147 aa) |
| | rps7 | SSU ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (215 aa) |
| | TK1065 | Molybdopterin converting factor, subunit 1. (82 aa) |
| | TK1047 | Translation initiation factor eIF-2B, delta subunit; Belongs to the eIF-2B alpha/beta/delta subunits family. (275 aa) |
| | TK1035 | Predicted glutamine amidotransferase, class II. (267 aa) |
| | TK1033 | Predicted metalloprotease, containing Jab1/MPN domain. (132 aa) |
| | TK1032 | Hydrogenase expression/formation protein HypE. (330 aa) |
| | TK1010 | Putative 5-methylcytosine restriction system, catalytic subunit. (467 aa) |
| | TK1009 | Putative 5-methylcytosine restriction system, GTPase subunit. (828 aa) |
| | pfdA1 | Prefoldin, alpha subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. (146 aa) |
| | TK0976 | snRNP component, Sm-like protein; Belongs to the snRNP Sm proteins family. (76 aa) |
| | rpl37e | LSU ribosomal protein L37E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (63 aa) |
| | TK0965 | Hypothetical protein, conserved, DUF79 family. (86 aa) |
| | TK0961 | Hydrogenase expression/formation protein HypE. (331 aa) |
| | TK0928 | Predicted DNA/RNA repair helicase. (461 aa) |
| | pheT | phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. (574 aa) |
| | rpl21e | LSU ribosomal protein L21E; Belongs to the eukaryotic ribosomal protein eL21 family. (98 aa) |
| | TK0901 | DNA-directed RNA polymerase, subunit F. (115 aa) |
| | nep1 | Ribosome biogenesis protein Nep1p homolog, suppressor Mra1 family; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. (220 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily. (483 aa) |
| | TK0852 | Hypothetical protein, conserved, radical SAM superfamily. (262 aa) |
| | rnhB | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (228 aa) |
| | TK0804 | ABC-type manganese/zinc transport system, permease component. (273 aa) |
| | TK0800 | RNA-binding protein, containing KH domain. (238 aa) |
| | top6B | Type II DNA topoisomerase VI, subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (567 aa) |
| | TK0795 | Putative 5-methylcytosine restriction system, GTPase subunit. (700 aa) |
| | TK0794 | Putative 5-methylcytosine restriction system, catalytic subunit. (476 aa) |
| | TK0791 | Hypothetical protein, conserved, DUF79 family. (88 aa) |
| | TK0745 | ABC-type cobalt transport system, permease component. (256 aa) |
| | TK0726 | ABC-type multidrug transport system, permease component. (239 aa) |
| | TK0708 | ABC-type iron(III)-siderophore transport system, ATPase component. (253 aa) |
| | TK0679 | Serine/threonine protein kinase, RIO1 family. (221 aa) |
| | pfdB | Prefoldin, beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. (117 aa) |
| | TK0642 | Hypothetical protein, conserved. (82 aa) |
| | TK0631 | Chemotaxis protein methyltransferase. (279 aa) |
| | TK0617 | U3 snoRNP component, archaeal imp4 homolog, containing Brix domain; Probably involved in the biogenesis of the ribosome. (208 aa) |
| | rpoP | DNA-directed RNA polymerase, subunit P; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (49 aa) |
| | pcn2 | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. (253 aa) |
| | pcn1 | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. (249 aa) |
| | coaBC | Phosphopantothenoylcysteine synthetase/decarboxylase; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Is specific for tRNA(Asp) since it aspartylates tRNA(Asn) 3 orders of magnitude less efficiently than tRNA(Asp); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. (438 aa) |
| | TK0436 | ABC-type transporter, ATPase component, fused to acetyltransferase domain. (633 aa) |
| | ribH | Riboflavin synthase, beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (156 aa) |
| | TK0361 | Hypothetical protein, conserved, DUF101 family; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity). (142 aa) |
| | rtcB | RNA terminal phosphate cyclase operon orfB homolog, UPF0027 family; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends; Belongs to the RtcB family. (482 aa) |
| | TK0337 | Predicted nucleic acid-binding protein, containing PIN domain and zinc-ribbon module. (178 aa) |
| | fusA | Translation elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF- [...] (732 aa) |
| | rps10 | SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa) |
| | leuD | Homoaconitase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | pdxT | Pyridoxine biosynthesis amidotransferase, SNO family; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (197 aa) |
| | TK0185 | Translation initiation factor eIF-2B, delta subunit; Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Only accepts the alpha-anomer of D-ribose 1,5-bisphosphate as substrate, being inactive on the beta-anomer. Displays a strict substrate specificity, since other phosphorylated sugars such as R5P, ribose, G16P, G6P, G1P, FBP, F6P, and PRPP, are not substrates. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO. (322 aa) |
| | TK0184 | snoRNP component, Nop56p/58p homolog. (420 aa) |
| | flpA | snoRNP component, Fibrillarin homolog; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (226 aa) |
| | gcvH | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (134 aa) |
| | ef1b | Translation elongation factor EF-1, beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (91 aa) |
| | TK0096 | DNA replication licensing factor, MCM2/3/5 family; Belongs to the MCM family. (914 aa) |
| | rnp4 | Ribonuclease P component, Rpp21 homolog; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (132 aa) |
| | tfb2 | Transcription initiation factor IIB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (306 aa) |
| | TK2286 | snoRNP component, Gar1 homolog. (115 aa) |
| | TK2269 | Hypothetical protein, conserved, DUF509 family. (135 aa) |
| | pan | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] (397 aa) |
| | TK2250 | Serine/threonine protein kinase, RIO1 family. (311 aa) |
| | prs | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). It can also use CTP and GTP as substrates in addition to ATP. (280 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (307 aa) |
| | rfcL | Replication factor C, large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (499 aa) |
| | rfcS | Replication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (866 aa) |
| | endA | Archaeal tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. (168 aa) |
| | TK2208 | ABC-type iron(III)-siderophore transport system, ATPase component. (242 aa) |
| | psmB2 | Proteasome, beta subunit 2; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (199 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (152 aa) |
| | kae1 | O-Sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (325 aa) |
| | TK2118 | Molybdopterin converting factor, subunit 1. (88 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa) |
| | TK2091 | Membrane bound hydrogenase, NiFe-hydrogenase large subunit 2. (426 aa) |
| | TK2090 | Membrane bound hydrogenase, NiFe-hydrogenase large subunit 1. (189 aa) |
| | TK2089 | Membrane bound hydrogenase, NiFe-hydrogenase small subunit. (176 aa) |
| | tfe | Transcription initiation factor IIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing [...] (185 aa) |
| | TK2020 | ABC-type iron(III)-siderophore transport system, ATPase component. (248 aa) |
| | hypA | Hydrogenase nickel-incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Belongs to the HypA/HybF family. (139 aa) |
| | TK1997 | Hydrogenase maturation protein HypF. (772 aa) |
| | TK1993 | Hydrogenase expression/formation protein HypE. (338 aa) |
| | nac | Transcription factor, nascent polypeptide-associated complex alpha homolog; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. (111 aa) |
| | TK1956 | Hypothetical protein, conserved, containing ATP/GTP-binding site motif A; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA (By similarity). (351 aa) |
| | TK1945 | Predicted nucleic acid-binding protein, containing PIN domain. (140 aa) |
| | TK1928 | Diphthine synthase, DPH2 subunit; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. (341 aa) |
| | TK1908 | Lipoate-protein ligase A, N-terminal section. (249 aa) |
| | polB | DNA polymerase II, small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (735 aa) |
| | cdc6 | Cell division control protein 6 homolog; Involved in regulation of DNA replication. (415 aa) |
| | radA | RadA/Rad51 recombinase; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity). (836 aa) |
| | TK1864 | ABC-type phosphate transport system, periplasmic component; Belongs to the PstS family. (383 aa) |
| | TK1821 | ATPase, PP-loop superfamily. (323 aa) |
| | priS | Eukaryotic-type DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after p [...] (346 aa) |
| | priL | Eukaryotic-type DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (400 aa) |
| | rnp2 | Ribonuclease P component, Rpp14 homolog; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family. (120 aa) |
| | TK1760 | ABC-type dipeptide/oligopeptide transport system, periplasmic component. (626 aa) |
| | glmA | exo-beta-D-glucosaminidase; Exo-type enzyme that specifically cleaves the non-reducing terminal glycosidic bond of chitooligosaccharides. Catalyzes the hydrolysis of GlcN- GlcNAc to glucosamine (GlcN) and N-acetylglucosamine (GlcNAc). Involved in chitin degradation. Can also hydrolyze reduced chitobiose (GlcN2OH) and chitooligosaccharides of various chain lengths. (786 aa) |
| | TK1736 | Ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1746 aa) |
| | TK1710 | Hypothetical protein, conserved, DUF86 family. (143 aa) |
| | TK1699 | DNA-directed RNA polymerase, subunit E'. (190 aa) |
| | spt4 | DNA-directed RNA polymerase subunit E'; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. (67 aa) |
| | TK1673 | N5-glutamine methyltransferase, HemK family. (194 aa) |
| | psmA | Proteasome, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (260 aa) |
| | rrp4 | Exosome subunit Rrp4p homolog, RNA-binding protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. (257 aa) |
| | rrp41 | Exosome subunit Rrp41p homolog, 3'-5' exoribonuclease; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails. (249 aa) |
| | rrp42 | Exosome subunit Rrp42p homolog, 3'-5' exoribonuclease; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. (272 aa) |
| | TK1629 | Hypothetical protein, conserved. (174 aa) |
| | TK1624 | methylmalonyl-CoA decarboxylase, gamma subunit. (157 aa) |
| | TK1622 | methylmalonyl-CoA decarboxylase, alpha subunit. (522 aa) |
| | TK1614 | NADH:ubiquinone oxidoreductase, subunit E. (154 aa) |
| | TK1613 | NADH:ubiquinone oxidoreductase, NADH-binding subunit F. (600 aa) |
| | atpD | Archaeal/vacuolar-type H+-ATPase, subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (214 aa) |
| | atpB | Archaeal/vacuolar-type H+-ATPase, subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (465 aa) |
| | atpA | Archaeal/vacuolar-type H+-ATPase, subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit; Belongs to the ATPase alpha/beta chains family. (585 aa) |
| | atpC | Archaeal/vacuolar-type H+-ATPase, subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane. (365 aa) |
| | atpE | Archaeal/vacuolar-type H+-ATPase, subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (203 aa) |
| | TK1598 | Archaeal/vacuolar-type H+-ATPase, subunit K. (161 aa) |
| | atpI | Archaeal/vacuolar-type H+-ATPase, subunit I; Produces ATP from ADP in the presence of a proton gradient across the membrane; Belongs to the V-ATPase 116 kDa subunit family. (663 aa) |
| | TK1581 | Hypothetical protein, conserved, UPF0113 family. (169 aa) |
| | TK1556 | ATPase, PP-loop superfamily. (304 aa) |
| | TK1549 | Predicetd ATPase. (193 aa) |
| | rpl10e | LSU ribosomal protein L10E; Belongs to the universal ribosomal protein uL16 family. (182 aa) |
| | rpl3 | LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (346 aa) |
| | rpl4 | LSU ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (255 aa) |
| | rpl23 | LSU ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (86 aa) |
| | rpl2 | LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (239 aa) |
| | rps19 | SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (133 aa) |
| | rpl22 | LSU ribosomal protein L22P; This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (156 aa) |
| | rps3 | SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (209 aa) |
| | rnp1 | Ribonuclease P component, Rpp29 homolog; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family. (125 aa) |
| | rps17 | SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (114 aa) |
| | rpl14 | LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (141 aa) |
| | rpl24 | LSU ribosomal protein L24P; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (121 aa) |
| | rps4e | SSU ribosomal protein S4E; Belongs to the eukaryotic ribosomal protein eS4 family. (243 aa) |
| | rpl5 | LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (183 aa) |
| | rps14 | SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (56 aa) |
| | rps8 | SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | TK2298 | Anaerobic ribonucleoside-triphosphate reductase. (610 aa) |
| | rpl6 | LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (184 aa) |
| | rpl32e | LSU ribosomal protein L32E; Belongs to the eukaryotic ribosomal protein eL32 family. (126 aa) |
| | rpl19e | LSU ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (150 aa) |
| | rpl18 | LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (201 aa) |
| | rps5 | SSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (235 aa) |
| | rpl30 | LSU ribosomal protein L30P. (155 aa) |
| | rpl15 | LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (148 aa) |
| | rpl14e | LSU ribosomal protein L14E; Belongs to the eukaryotic ribosomal protein eL14 family. (83 aa) |
| | TK1511 | Hypothetical protein, conserved, UPF0150 family. (73 aa) |
| | TK1507 | Ribosomal RNA small subunit methyltransferase C. (195 aa) |
| | rps13 | SSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (149 aa) |
| | rps4 | SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (180 aa) |
| | rps11 | SSU ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (140 aa) |
| | rpoD | DNA-directed RNA polymerase, subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. (259 aa) |
| | rpl18e | LSU ribosomal protein L18E; Belongs to the eukaryotic ribosomal protein eL18 family. (121 aa) |
| | rpl13 | LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa) |
| | rps9 | SSU ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (135 aa) |
| | rpoN | DNA-directed RNA polymerase subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (65 aa) |
| | rpoK | DNA-directed RNA polymerase, subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (57 aa) |
| | TK1497 | Enolase-related protein. (341 aa) |
| | rps2 | SSU ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family. (201 aa) |
| | srp54 | Signal recognition particle, SRP54 subunit; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (448 aa) |
| | TK1475 | Hypothetical protein, conserved, DUF86 family. (140 aa) |
| | rpl15e | LSU ribosomal protein L15E; Belongs to the eukaryotic ribosomal protein eL15 family. (194 aa) |
| | rnp3 | Ribonuclease P component, Rpp30 homolog; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family. (220 aa) |
| | TK1439 | Probable nickel responsive regulator; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (138 aa) |
| | TK1438 | Predicted fibronectin-binding protein. (650 aa) |
| | psmB1 | Proteasome, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (203 aa) |
| | rpl11 | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (165 aa) |
| | rpl1 | LSU ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (216 aa) |
| | rpl10 | LSU ribosomal protein L10E; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (340 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (155 aa) |
| | dnaG | DnaG-related protein, containing Toprim domain; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (464 aa) |
| | gcvPA | Glycine cleavage system protein P, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (451 aa) |
| | gcvPB | Glycine cleavage system protein P, subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (502 aa) |
| | TK1361 | DNA replication licensing factor, MCM2/3/5 family; Belongs to the MCM family. (810 aa) |
| | srp19 | Signal recognition particle, SRP19 subunit; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. (108 aa) |
| | TK1328 | tRNA (1-methyladenosine) methyltransferase. (253 aa) |
| | eif6 | Translation initiation factor eIF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (229 aa) |
| | rpl31e | LSU ribosomal protein L31E; Belongs to the eukaryotic ribosomal protein eL31 family. (90 aa) |
| | rpl39e | LSU ribosomal protein L39E; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa) |
| | rpl7ae | LSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (125 aa) |
| | rps28e | SSU ribosomal protein S28E; Belongs to the eukaryotic ribosomal protein eS28 family. (70 aa) |
| | tfb1 | Transcription initiation factor IIB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (300 aa) |
| | TK1262 | Predicted metalloprotease, containing Jab1/MPN domain. (123 aa) |
| | rps15 | SSU ribosomal protein S15P. (151 aa) |
| | prf1 | Peptide chain release factor eRF1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (415 aa) |
| | TK1234 | Lipoate-protein ligase A, C-terminal section. (92 aa) |
| | TK1199 | TBP-interacting protein Tip49 homolog. (440 aa) |
| | rps8e | SSU ribosomal protein S8E. (130 aa) |
