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| | TK2304 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family, fused to N-terminal NusB regulator domain; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (450 aa) |
| | pth | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. (118 aa) |
| | TK2298 | Anaerobic ribonucleoside-triphosphate reductase. (610 aa) |
| | rps17e | SSU ribosomal protein S17E; Belongs to the eukaryotic ribosomal protein eS17 family. (67 aa) |
| | TK2277 | Hypothetical protein, conserved. (200 aa) |
| | TK2275 | RNA-binding protein, containing PUA domain. (172 aa) |
| | TK2255 | Bifunctional phosphatase/dolichol-phosphate glucosyltransferase. (440 aa) |
| | TK2254 | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase. (298 aa) |
| | pan | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] (397 aa) |
| | lysS | lysyl-tRNA synthetase. (526 aa) |
| | radB | RadB recombinase; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity). (220 aa) |
| | TK2223 | Met-10+ like protein. (337 aa) |
| | rfcL | Replication factor C, large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (499 aa) |
| | rfcS | Replication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (866 aa) |
| | mre11 | DNA repair exonuclease Rad32/Mre11 homolog; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (460 aa) |
| | rad50 | DNA double-strand break repair ATPase Rad50 homolog; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (883 aa) |
| | TK2152 | Hypothetical protein, conserved, DUF431 family. (211 aa) |
| | TK2143 | Uracil-DNA glycosylase. (196 aa) |
| | lig | ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Can also use NAD, but less efficiently than ATP; Belongs to the ATP-dependent DNA ligase family. (562 aa) |
| | TK2135 | 23S rRNA (uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (417 aa) |
| | TK2122 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family, containing RNA-binding PUA domain; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (383 aa) |
| | ogt | methylated-DNA-protein-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family. (174 aa) |
| | TK1970 | Probable tRNA/rRNA methyltransferase, SpoU family. (235 aa) |
| | TK1961 | Replication factor A complex, RPA41 subunit. (356 aa) |
| | rps6e | SSU ribosomal protein S6E; Belongs to the eukaryotic ribosomal protein eS6 family. (125 aa) |
| | eif2g | Translation initiation factor eIF-2, gamma subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (410 aa) |
| | TK1935 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (450 aa) |
| | TK1933 | Predicted DNA methylase. (209 aa) |
| | TK1932 | ATPase, RecA superfamily. (448 aa) |
| | TK1909 | Dolichol-phosphate mannosyltransferase, fused to membrane-bound GtrA-like domain. (352 aa) |
| | taw3-2 | Hypothetical protein, conserved, DUF207 family; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. (212 aa) |
| | polC | DNA polymerase II, large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity). (1798 aa) |
| | polB | DNA polymerase II, small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (735 aa) |
| | cdc6 | Cell division control protein 6 homolog; Involved in regulation of DNA replication. (415 aa) |
| | radA | RadA/Rad51 recombinase; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity). (836 aa) |
| | nucS | Hypothetical protein, conserved, DUF91 family; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (252 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (384 aa) |
| | TK1865 | Predicted AP endonuclease. (271 aa) |
| | TK1863 | Predicted N6-adenine-specific DNA methylase. (365 aa) |
| | TK1842 | Probable transposase. (393 aa) |
| | TK1841 | Predicted site-specific integrase-resolvase. (202 aa) |
| | TK1830 | Probable alpha-amylase, GH57 family. (361 aa) |
| | priS | Eukaryotic-type DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after p [...] (346 aa) |
| | priL | Eukaryotic-type DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (400 aa) |
| | TK1784 | Predicted SAM-dependent methyltransferase, DUF890 family. (248 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1065 aa) |
| | TK1736 | Ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1746 aa) |
| | TK1732 | Dolichol-phosphate mannosyltransferase, fused to C-terminal uncharacterized domain. (373 aa) |
| | TK1720 | Dolichol-phosphate mannosyltransferase. (241 aa) |
| | TK1718 | Oligosaccharyl transferase, STT3 subunit. (766 aa) |
| | rps24e | SSU ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family. (98 aa) |
| | rps27ae | SSU ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family. (57 aa) |
| | TK1673 | N5-glutamine methyltransferase, HemK family. (194 aa) |
| | TK1640 | Nucleotide pyrophosphohydrolase. (106 aa) |
| | psmA | Proteasome, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (260 aa) |
| | rrp4 | Exosome subunit Rrp4p homolog, RNA-binding protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. (257 aa) |
| | rrp41 | Exosome subunit Rrp41p homolog, 3'-5' exoribonuclease; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails. (249 aa) |
| | rrp42 | Exosome subunit Rrp42p homolog, 3'-5' exoribonuclease; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. (272 aa) |
| | eif2b | Translation initiation factor eIF-2, beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (142 aa) |
| | TK1607 | alanyl-tRNA synthetase-related protein (C-terminus). (406 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (917 aa) |
| | hisS | histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (436 aa) |
| | TK1550 | asparaginyl-tRNA synthetase-related protein (N-truncation). (299 aa) |
| | rpl10e | LSU ribosomal protein L10E; Belongs to the universal ribosomal protein uL16 family. (182 aa) |
| | rpl3 | LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (346 aa) |
| | rpl4 | LSU ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (255 aa) |
| | rpl23 | LSU ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (86 aa) |
| | rpl2 | LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (239 aa) |
| | rps19 | SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (133 aa) |
| | rpl22 | LSU ribosomal protein L22P; This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (156 aa) |
| | rps3 | SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (209 aa) |
| | rpl29 | LSU ribosomal protein L29P; Belongs to the universal ribosomal protein uL29 family. (66 aa) |
| | TK1534 | Protein translation factor SUI1 homolog; Belongs to the SUI1 family. (98 aa) |
| | rps17 | SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (114 aa) |
| | rpl14 | LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (141 aa) |
| | rpl24 | LSU ribosomal protein L24P; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (121 aa) |
| | rps4e | SSU ribosomal protein S4E; Belongs to the eukaryotic ribosomal protein eS4 family. (243 aa) |
| | rpl5 | LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (183 aa) |
| | rps14 | SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (56 aa) |
| | rps8 | SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rpl6 | LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (184 aa) |
| | rpl32e | LSU ribosomal protein L32E; Belongs to the eukaryotic ribosomal protein eL32 family. (126 aa) |
| | rpl19e | LSU ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (150 aa) |
| | rpl18 | LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (201 aa) |
| | rps5 | SSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (235 aa) |
| | rpl30 | LSU ribosomal protein L30P. (155 aa) |
| | rpl15 | LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (148 aa) |
| | rpl34e | LSU ribosomal protein L34E; Belongs to the eukaryotic ribosomal protein eL34 family. (90 aa) |
| | rpl14e | LSU ribosomal protein L14E; Belongs to the eukaryotic ribosomal protein eL14 family. (83 aa) |
| | rps13 | SSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (149 aa) |
| | rps4 | SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (180 aa) |
| | rps11 | SSU ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (140 aa) |
| | rpl18e | LSU ribosomal protein L18E; Belongs to the eukaryotic ribosomal protein eL18 family. (121 aa) |
| | rpl13 | LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa) |
| | rps9 | SSU ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (135 aa) |
| | rps2 | SSU ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family. (201 aa) |
| | rpl40e | LSU ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. (51 aa) |
| | rnj | Hydrolase, metallo-beta-lactamase superfamily; An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily. (444 aa) |
| | leuS | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (967 aa) |
| | TK1460 | Predicted endonuclease-methyltransferase fusion protein. (1282 aa) |
| | rpl15e | LSU ribosomal protein L15E; Belongs to the eukaryotic ribosomal protein eL15 family. (194 aa) |
| | TK1438 | Predicted fibronectin-binding protein. (650 aa) |
| | TK1436 | Probable alpha-amylase, GH57 family; Catalyzes the formation of branch points in alpha-glucans by cleavage of an alpha-1,4 glycosidic bond and subsequent transfer of the cleaved-off oligosaccharide to a new alpha-1,6 position. The branch chain-length distribution of the reaction products shows degree of polymerization (DP) of 5 to 30, with two local maxima at DP 6 and DP 11. Exhibits an alpha-retaining catalytic mechanism. Does not display alpha-galactosidase or pullulanase activity, since melibiose and pullulan are not substrates. Is not able to catalyze the hydrolysis or transglycosy [...] (675 aa) |
| | spt5 | Transcription antitermination protein; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (152 aa) |
| | rpl11 | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (165 aa) |
| | rpl1 | LSU ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (216 aa) |
| | rpl10 | LSU ribosomal protein L10E; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (340 aa) |
| | rpl12 | LSU ribosomal protein L12A; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (106 aa) |
| | dnaG | DnaG-related protein, containing Toprim domain; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (464 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (573 aa) |
| | TK1386 | Metallophosphoesterase, calcineurin superfamily. (225 aa) |
| | TK1342 | Predicted integrase, C-fragment. (318 aa) |
| | hel308 | RNA helicase Ski2 homolog; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (1125 aa) |
| | TK1328 | tRNA (1-methyladenosine) methyltransferase. (253 aa) |
| | rpl18a | LSU ribosomal protein L20A. (77 aa) |
| | eif6 | Translation initiation factor eIF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (229 aa) |
| | rpl31e | LSU ribosomal protein L31E; Belongs to the eukaryotic ribosomal protein eL31 family. (90 aa) |
| | rpl39e | LSU ribosomal protein L39E; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa) |
| | tdk | Thymidine kinase. (197 aa) |
| | TK1313 | Hypothetical protein, conserved. (203 aa) |
| | rpl7ae | LSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (125 aa) |
| | rps28e | SSU ribosomal protein S28E; Belongs to the eukaryotic ribosomal protein eS28 family. (70 aa) |
| | rpl24e | LSU ribosomal protein L24E; Binds to the 23S rRNA. (67 aa) |
| | infB | Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity). (1144 aa) |
| | TK1293 | Putative membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase. (825 aa) |
| | TK1290 | Predicted nucleic acid-binding protein, containing PIN domain. (138 aa) |
| | TK1286 | Predicted GTPase, GTP1/OBG family, containing TGS domain. (388 aa) |
| | fen | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] (340 aa) |
| | rps19e | SSU ribosomal protein S19E; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (150 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (888 aa) |
| | TK1257 | RNA-binding protein, containing THUMP domain. (355 aa) |
| | vapC-8 | Predicted nucleic acid-binding protein, containing PIN domain; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (141 aa) |
| | rps3ae | SSU ribosomal protein S3AE; Belongs to the eukaryotic ribosomal protein eS1 family. (200 aa) |
| | rps15 | SSU ribosomal protein S15P. (151 aa) |
| | prf1 | Peptide chain release factor eRF1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (415 aa) |
| | argS | arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (642 aa) |
| | rps8e | SSU ribosomal protein S8E. (130 aa) |
| | hjc | Archaeal type Holliday junction resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. (128 aa) |
| | thrS | Threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr); Belongs to the class-II aminoacyl-tRNA synthetase family. (626 aa) |
| | csl4 | RNA-binding protein, containing S1 domain; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. (198 aa) |
| | TK1158 | Predicted endonuclease-methyltransferase fusion protein. (1125 aa) |
| | TK1147 | Predicted type II restriction endonuclease. (710 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (246 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (455 aa) |
| | TK1116 | 23S rRNA (uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (421 aa) |
| | eif2a | Translation initiation factor eIF-2, alpha subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (275 aa) |
| | rps27e | SSU ribosomal protein S27E. (65 aa) |
| | rpl44e | LSU ribosomal protein L44E; Binds to the 23S rRNA. (94 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (1229 aa) |
| | rpl30e | LSU ribosomal protein L30E; Belongs to the eukaryotic ribosomal protein eL30 family. (102 aa) |
| | rps12 | SSU ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (147 aa) |
| | rps7 | SSU ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (215 aa) |
| | TK1067 | Hypothetical protein, conserved, containing DUF650 and DUF651 domains; Involved in DNA damage repair. (412 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (741 aa) |
| | TK1047 | Translation initiation factor eIF-2B, delta subunit; Belongs to the eIF-2B alpha/beta/delta subunits family. (275 aa) |
| | TK1031 | Predicted ATPase, RNase L inhibitor homolog. (594 aa) |
| | TK1021 | Helicase-associated endonuclease for fork-structured DNA. (804 aa) |
| | smc | Chromosome segregation ATPase; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1189 aa) |
| | TK0984 | alanyl-tRNA synthetase-related protein (partial). (215 aa) |
| | TK0981 | N2, N2-dimethylguanosine tRNA methyltransferase. (331 aa) |
| | glyS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). (570 aa) |
| | rpl37e | LSU ribosomal protein L37E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (63 aa) |
| | trm1 | N2,N2-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (376 aa) |
| | rpl35ae | LSU ribosomal protein L35AE; Belongs to the eukaryotic ribosomal protein eL33 family. (86 aa) |
| | pelA | Cell division protein pelota homolog; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. (357 aa) |
| | TK0940 | Hypothetical protein, conserved; DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double- stranded DNA substrates. (263 aa) |
| | TK0932 | IS200-like transposase. (136 aa) |
| | TK0931 | Probable transposase. (391 aa) |
| | pheT | phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. (574 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha subunit. (501 aa) |
| | gatE | Archaeal Glu-tRNA(Gln) amidotransferase, subunit E containing GAD domain; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (629 aa) |
| | gatD | Archaeal Glu-tRNA(Gln) amidotransferase, subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (440 aa) |
| | nfi | Endonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (197 aa) |
| | rpl21e | LSU ribosomal protein L21E; Belongs to the eukaryotic ribosomal protein eL21 family. (98 aa) |
| | rsmA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (279 aa) |
| | eif5a | Translation initiation factor eIF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (136 aa) |
| | nep1 | Ribosome biogenesis protein Nep1p homolog, suppressor Mra1 family; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. (220 aa) |
| | TK0872 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (309 aa) |
| | TK0850 | Probable transposase. (431 aa) |
| | TK0810 | Oligosaccharyl transferase, STT3 subunit. (1000 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (602 aa) |
| | TK0807 | Hypothetical protein, conserved. (383 aa) |
| | rnhB | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (228 aa) |
| | eif1a | Translation initiation factor eIF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (117 aa) |
| | top6B | Type II DNA topoisomerase VI, subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (567 aa) |
| | top6A | Type II DNA topoisomerase VI, subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (385 aa) |
| | TK0796 | DNA-binding protein, containing HTH domain of resolvase. (139 aa) |
| | xerA | Integrase/recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Belongs to the 'phage' integrase family. XerA subfamily. (282 aa) |
| | TK0773 | Predicted ATP-dependent endonuclease, OLD family. (648 aa) |
| | asnS | asparaginyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (431 aa) |
| | TK0722 | Probable protein-S isoprenylcysteine O-methyltransferase. (143 aa) |
| | mutS2 | MutS-like DNA mismatch repair ATPase; Has ATPase and non-specific DNA-binding activities. Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily. (576 aa) |
| | TK0655 | Predicted site-specific integrase/resolvase. (209 aa) |
| | TK0654 | Probable transposase. (417 aa) |
| | TK0649 | Putative tRNA-binding protein. (241 aa) |
| | rpl37ae | LSU ribosomal protein L37AE. (86 aa) |
| | TK0614 | SSV1 integrase homolog, C-fragment. (317 aa) |
| | pcn2 | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. (253 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily. (375 aa) |
| | TK0556 | Translation initiation factor eIF-2B, beta subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (356 aa) |
| | trmY | Hypothetical protein, conserved, DUF358 family; Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs; Belongs to the methyltransferase superfamily. TrmY family. (198 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (481 aa) |
| | pcn1 | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. (249 aa) |
| | TK0521 | DEAD/DEAH box RNA helicase, fused to C-terminal uncharacterized domain. (900 aa) |
| | TK0497 | Met-10+ like protein. (331 aa) |
| | TK0495 | Probable transposase. (420 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Is specific for tRNA(Asp) since it aspartylates tRNA(Asn) 3 orders of magnitude less efficiently than tRNA(Asp); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. (438 aa) |
| | rgy | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity); In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily. (1711 aa) |
| | TK0461 | Hypothetical protein, conserved, RAMP superfamily. (210 aa) |
| | cas1 | Hypothetical protein, conserved, DUF48 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (326 aa) |
| | cas2 | Hypothetical protein, conserved, DUF196 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (85 aa) |
| | cysS | cysteinyl-tRNA synthetase. (476 aa) |
| | TK0422 | tRNA m1G methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of either N(1)-methyladenine or N(1)-methylguanine at position 9 (m1A9 or m1G9) in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family. (370 aa) |
| | TK0381 | SSV1 integrase homolog, C-fragment. (287 aa) |
| | TK0366 | ThiI-related protein. (191 aa) |
| | TK0364 | Dolichol-phosphate mannosyltransferase. (221 aa) |
| | TK0360 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (312 aa) |
| | TK0345 | 3-methyladenine DNA glycosylase. (280 aa) |
| | TK0317 | TatD-related deoxyribonuclease. (252 aa) |
| | fusA | Translation elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF- [...] (732 aa) |
| | tuf | Translation elongation factor EF-1, alpha subunit; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (428 aa) |
| | rps10 | SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa) |
| | TK0303 | Membrane-bound metal-dependent hydrolase. (583 aa) |
| | TK0298 | Probable transposase. (431 aa) |
| | TK0242 | ATP phosphoribosyltransferase, predicted regulatory subunit. (293 aa) |
| | TK0239 | Putative tRNA-binding protein. (109 aa) |
| | TK0219 | Sugar-phosphate nucleotidyltransferase. (413 aa) |
| | flpA | snoRNP component, Fibrillarin homolog; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (226 aa) |
| | taw3-1 | Hypothetical protein, conserved, DUF207 family; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. (198 aa) |
| | TK0170 | Endonuclease IV. (281 aa) |
| | ef1b | Translation elongation factor EF-1, beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (91 aa) |
| | TK0104 | Probable integrase/recombinase. (172 aa) |
| | TK0073 | SSV1 integrase homolog, C-fragment. (297 aa) |
| | taw2 | Met-10+ like protein; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). (278 aa) |
| | TK0060 | Hypothetical protein, conserved, DUF127 family; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. (180 aa) |
| | TK0051 | protein-L-isoaspartate carboxylmethyltransferase, flame shift. (170 aa) |
| | TK0026 | Probable phosphoglycolate phosphatase, HAD superfamily. (217 aa) |
| | TK0019 | Predicted ABC-type transport system, ATPase component. (339 aa) |
| | vapC | Predicted nucleic acid-binding protein, containing PIN domain; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (138 aa) |
| | TK0008 | Predicted DNA methylase. (366 aa) |
| | pol | DNA-directed DNA polymerase, family B; Intein encoded endonucleases are thought to mediate intein mobility by site-specific recombination initiated by endonuclease cleavage at the 'homing site' in gene that lack the intein. PI-PkoI recognizes 5'-GATTTAGATCCCTGTACC-3' and PI-PkoII recognizes 5'- CAGCTACTACGGTTAC-3'. (1671 aa) |
