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| | pth | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. (118 aa) |
| | TK2299 | Anaerobic ribonucleoside-triphosphate reductase activating enzyme. (236 aa) |
| | rps17e | SSU ribosomal protein S17E; Belongs to the eukaryotic ribosomal protein eS17 family. (67 aa) |
| | TK2277 | Hypothetical protein, conserved. (200 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (213 aa) |
| | TK2275 | RNA-binding protein, containing PUA domain. (172 aa) |
| | ribL | Glycerol-3-phosphate cytidylyltransferase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (149 aa) |
| | queC | Predicted transcription regulator, ExsB family; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (239 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (302 aa) |
| | TK2255 | Bifunctional phosphatase/dolichol-phosphate glucosyltransferase. (440 aa) |
| | lysS | lysyl-tRNA synthetase. (526 aa) |
| | prs | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). It can also use CTP and GTP as substrates in addition to ATP. (280 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (307 aa) |
| | TK2217 | 2-amino-3-oxobutyrate coenzyme A ligase; Glycine C-acetyltransferase. (395 aa) |
| | TK2205 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (381 aa) |
| | pyrB | Aspartate carbamoyltransferase, catalytic subunit. (310 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (152 aa) |
| | TK2141 | GHMP kinase; Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. Displays broad nucleotide specificity and utilizes ATP, GTP, UTP, and CTP with comparable catalytic efficiencies. (300 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (185 aa) |
| | TK2130 | ATP:corrinoid adenosyltransferase. (175 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. (165 aa) |
| | nadK | ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (278 aa) |
| | TK2118 | Molybdopterin converting factor, subunit 1. (88 aa) |
| | TK2115 | Molybdopterin converting factor, subunit 2. (141 aa) |
| | TK2101 | Aminotransferase, class III; L-ornithine aminotransferase involved in L-proline biosynthesis. Also shows high activity toward L-lysine. 2-oxoglutarate is the best amino acceptor, but 2-oxoadipate also leads to moderate activity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa) |
| | hydG | Cytosolic NiFe-hydrogenase, gamma subunit. (294 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (201 aa) |
| | porG | Pyruvate/2-oxoisovalerate: ferredoxin oxidoreductases, common gamma subunit. (185 aa) |
| | TK1968 | 2-dehydropantoate 2-reductase; Catalyzes the NAD(P)H-dependent reduction of ketopantoate into pantoic acid. Prefers NADH rather than NADPH as the electron donor. (309 aa) |
| | rps6e | SSU ribosomal protein S6E; Belongs to the eukaryotic ribosomal protein eS6 family. (125 aa) |
| | eif2g | Translation initiation factor eIF-2, gamma subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (410 aa) |
| | TK1909 | Dolichol-phosphate mannosyltransferase, fused to membrane-bound GtrA-like domain. (352 aa) |
| | taw3-2 | Hypothetical protein, conserved, DUF207 family; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. (212 aa) |
| | mtnP | Purine-nucleoside phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (257 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (384 aa) |
| | mfnA | Glutamate decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine. In vitro, can also catalyzes the decarboxylation of L- glutamate to produce 4-aminobutanoate, but this activity does not seem necessary in vivo. Shows much higher activity with L-aspartate than with L-glutamate. Does not decarboxylate L-tyrosine. Belongs to the group II decarboxylase family. MfnA subfamily. (384 aa) |
| | TK1811 | Hydrolase, HAD superfamily. (231 aa) |
| | pyrK | Probable dihydroorotate dehydrogenase, electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (233 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (409 aa) |
| | nadE | NH3-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (254 aa) |
| | glnA | Glutamine synthetase; Carries out the ATP-dependent synthesis of glutamine from ammonium nitrogen and glutamate. Exhibits both L-gamma- glutamylhydroxamate synthetase and gamma-glutamyltransferase activities when using hydroxylamine as substrate; in fact, the enzyme possesses low biosynthetic activity, suggesting that the reaction is biased towards the degradation of glutamine under ammonia-rich conditions. Might play some role in ammonia assimilation under ammonia-starvation conditions. Can also use GTP instead of ATP in the synthetase reaction, but not CTP or UTP. (443 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1065 aa) |
| | TK1732 | Dolichol-phosphate mannosyltransferase, fused to C-terminal uncharacterized domain. (373 aa) |
| | TK1720 | Dolichol-phosphate mannosyltransferase. (241 aa) |
| | TK1718 | Oligosaccharyl transferase, STT3 subunit. (766 aa) |
| | TK1697 | Hypothetical protein, conserved, DUF359 family; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). Can also use UTP, with lower efficiency and has weak activity with ATP, but shows a strong preference for GTP as the phosphate donor. (177 aa) |
| | rps24e | SSU ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family. (98 aa) |
| | rps27ae | SSU ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family. (57 aa) |
| | bpsA | Hypothetical protein, conserved, DUF43 family; Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine. Can also use spermine to produce N(4)-aminopropylspermine. (351 aa) |
| | TK1687 | Cysteine synthase. (273 aa) |
| | TK1686 | Hypothetical protein, conserved, DUF137 family; Catalyzes the condensation of (R)-4-phosphopantoate and beta- alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway. Cannot use (R)- pantoate as substrate and thus does not display pantothenate synthetase (PS) activity. Displays strict specificity for its natural substrates, 4-phosphopantoate, ATP and beta-alanine. (261 aa) |
| | TK1685 | ferredoxin:NADP oxidoreductase, beta subunit. (284 aa) |
| | TK1676 | Nicotinate-nucleotide pyrophosphorylase. (390 aa) |
| | TK1627 | Homoserine dehydrogenase. (334 aa) |
| | eif2b | Translation initiation factor eIF-2, beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (142 aa) |
| | TK1607 | alanyl-tRNA synthetase-related protein (C-terminus). (406 aa) |
| | atpD | Archaeal/vacuolar-type H+-ATPase, subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (214 aa) |
| | atpB | Archaeal/vacuolar-type H+-ATPase, subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (465 aa) |
| | atpA | Archaeal/vacuolar-type H+-ATPase, subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit; Belongs to the ATPase alpha/beta chains family. (585 aa) |
| | atpF | Archaeal/vacuolar-type H+-ATPase, subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane. (102 aa) |
| | atpC | Archaeal/vacuolar-type H+-ATPase, subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane. (365 aa) |
| | atpE | Archaeal/vacuolar-type H+-ATPase, subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (203 aa) |
| | speH | S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (143 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (917 aa) |
| | hisS | histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (436 aa) |
| | TK1550 | asparaginyl-tRNA synthetase-related protein (N-truncation). (299 aa) |
| | TK1548 | Probable serine--glyoxylate aminotransferase, class V. (385 aa) |
| | rpl10e | LSU ribosomal protein L10E; Belongs to the universal ribosomal protein uL16 family. (182 aa) |
| | rpl3 | LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (346 aa) |
| | rpl4 | LSU ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (255 aa) |
| | rpl23 | LSU ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (86 aa) |
| | rpl2 | LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (239 aa) |
| | rps19 | SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (133 aa) |
| | rpl22 | LSU ribosomal protein L22P; This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (156 aa) |
| | rps3 | SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (209 aa) |
| | rpl29 | LSU ribosomal protein L29P; Belongs to the universal ribosomal protein uL29 family. (66 aa) |
| | TK1534 | Protein translation factor SUI1 homolog; Belongs to the SUI1 family. (98 aa) |
| | rps17 | SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (114 aa) |
| | rpl14 | LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (141 aa) |
| | rpl24 | LSU ribosomal protein L24P; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (121 aa) |
| | rps4e | SSU ribosomal protein S4E; Belongs to the eukaryotic ribosomal protein eS4 family. (243 aa) |
| | rpl5 | LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (183 aa) |
| | rps14 | SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (56 aa) |
| | rps8 | SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rpl6 | LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (184 aa) |
| | rpl32e | LSU ribosomal protein L32E; Belongs to the eukaryotic ribosomal protein eL32 family. (126 aa) |
| | rpl19e | LSU ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (150 aa) |
| | rpl18 | LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (201 aa) |
| | rps5 | SSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (235 aa) |
| | rpl30 | LSU ribosomal protein L30P. (155 aa) |
| | rpl15 | LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (148 aa) |
| | rpl34e | LSU ribosomal protein L34E; Belongs to the eukaryotic ribosomal protein eL34 family. (90 aa) |
| | rpl14e | LSU ribosomal protein L14E; Belongs to the eukaryotic ribosomal protein eL14 family. (83 aa) |
| | rps13 | SSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (149 aa) |
| | rps4 | SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (180 aa) |
| | rps11 | SSU ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (140 aa) |
| | rpl18e | LSU ribosomal protein L18E; Belongs to the eukaryotic ribosomal protein eL18 family. (121 aa) |
| | rpl13 | LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa) |
| | rps9 | SSU ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (135 aa) |
| | rps2 | SSU ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family. (201 aa) |
| | rpl40e | LSU ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. (51 aa) |
| | TK1482 | Purine-nucleoside phosphorylase; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. (267 aa) |
| | TK1479 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (277 aa) |
| | TK1478 | Threonine synthase. (354 aa) |
| | leuS | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (967 aa) |
| | rpl15e | LSU ribosomal protein L15E; Belongs to the eukaryotic ribosomal protein eL15 family. (194 aa) |
| | TK1449 | Cystathionine gamma-synthase. (366 aa) |
| | TK1447 | Methionine synthase II (cobalamin-independent). (309 aa) |
| | metE | Methionine synthase II (cobalamin-independent); Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown (By similarity). (336 aa) |
| | TK1445 | Aspartokinase. (366 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (292 aa) |
| | TK1443 | Aspartate-semialdehyde dehydrogenase. (335 aa) |
| | trpB2 | Tryptophan synthase beta subunit-related protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (442 aa) |
| | TK1438 | Predicted fibronectin-binding protein. (650 aa) |
| | spt5 | Transcription antitermination protein; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (152 aa) |
| | rpl11 | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (165 aa) |
| | rpl1 | LSU ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (216 aa) |
| | rpl10 | LSU ribosomal protein L10E; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (340 aa) |
| | rpl12 | LSU ribosomal protein L12A; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (106 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (155 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (573 aa) |
| | tmk | Thymidylate kinase. (205 aa) |
| | TK1326 | ferredoxin:NADP oxidoreductase, beta subunit. (291 aa) |
| | rpl18a | LSU ribosomal protein L20A. (77 aa) |
| | eif6 | Translation initiation factor eIF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (229 aa) |
| | rpl31e | LSU ribosomal protein L31E; Belongs to the eukaryotic ribosomal protein eL31 family. (90 aa) |
| | rpl39e | LSU ribosomal protein L39E; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa) |
| | TK1313 | Hypothetical protein, conserved. (203 aa) |
| | rpl7ae | LSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (125 aa) |
| | rps28e | SSU ribosomal protein S28E; Belongs to the eukaryotic ribosomal protein eS28 family. (70 aa) |
| | rpl24e | LSU ribosomal protein L24E; Binds to the 23S rRNA. (67 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (174 aa) |
| | infB | Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity). (1144 aa) |
| | TK1301 | Probable ATP-NAD kinase. (381 aa) |
| | TK1293 | Putative membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase. (825 aa) |
| | upp | Uracilphosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (230 aa) |
| | TK1286 | Predicted GTPase, GTP1/OBG family, containing TGS domain. (388 aa) |
| | TK1283 | Predicted ATPase, PP-loop superfamily. (215 aa) |
| | TK1282 | Molybdenum cofactor biosynthesis protein MoeA. (400 aa) |
| | rps19e | SSU ribosomal protein S19E; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (150 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (888 aa) |
| | ribK | Predicted transcription regulator, containing Crp and DUF120 domains; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (211 aa) |
| | rps3ae | SSU ribosomal protein S3AE; Belongs to the eukaryotic ribosomal protein eS1 family. (200 aa) |
| | rps15 | SSU ribosomal protein S15P. (151 aa) |
| | prf1 | Peptide chain release factor eRF1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (415 aa) |
| | argS | arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (642 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (533 aa) |
| | rps8e | SSU ribosomal protein S8E. (130 aa) |
| | thrS | Threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr); Belongs to the class-II aminoacyl-tRNA synthetase family. (626 aa) |
| | TK1161 | Dihydropteroate synthase. (272 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (455 aa) |
| | eif2a | Translation initiation factor eIF-2, alpha subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (275 aa) |
| | rps27e | SSU ribosomal protein S27E. (65 aa) |
| | rpl44e | LSU ribosomal protein L44E; Binds to the 23S rRNA. (94 aa) |
| | rpl30e | LSU ribosomal protein L30E; Belongs to the eukaryotic ribosomal protein eL30 family. (102 aa) |
| | rps12 | SSU ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (147 aa) |
| | rps7 | SSU ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (215 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (741 aa) |
| | TK1047 | Translation initiation factor eIF-2B, delta subunit; Belongs to the eIF-2B alpha/beta/delta subunits family. (275 aa) |
| | TK1031 | Predicted ATPase, RNase L inhibitor homolog. (594 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (339 aa) |
| | TK0984 | alanyl-tRNA synthetase-related protein (partial). (215 aa) |
| | glyS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). (570 aa) |
| | rpl37e | LSU ribosomal protein L37E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (63 aa) |
| | rpl35ae | LSU ribosomal protein L35AE; Belongs to the eukaryotic ribosomal protein eL33 family. (86 aa) |
| | TK0950 | Asparagine synthase (glutamine-hydrolyzing). (483 aa) |
| | TK0934 | Molybdopterin-guanine dinucleotide biosynthesis protein B. (244 aa) |
| | pheT | phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. (574 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha subunit. (501 aa) |
| | gatE | Archaeal Glu-tRNA(Gln) amidotransferase, subunit E containing GAD domain; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (629 aa) |
| | gatD | Archaeal Glu-tRNA(Gln) amidotransferase, subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (440 aa) |
| | rpl21e | LSU ribosomal protein L21E; Belongs to the eukaryotic ribosomal protein eL21 family. (98 aa) |
| | thiL | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (309 aa) |
| | TK0882 | Agmatinase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the decarboxylation of N1-(3-aminopropyl)agmatine to yield spermidine and urea. It can also use agmatine to yield putrescine. (288 aa) |
| | eif5a | Translation initiation factor eIF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (136 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (315 aa) |
| | thyX | Alternative thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (245 aa) |
| | cobD | Cobinamide synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (294 aa) |
| | cobS | Cobalamin-5-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (231 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily. (483 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (174 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (381 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (224 aa) |
| | TK0810 | Oligosaccharyl transferase, STT3 subunit. (1000 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (602 aa) |
| | eif1a | Translation initiation factor eIF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (117 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). (334 aa) |
| | tgtA | Archaeosine tRNA-guanine transglycosylase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (580 aa) |
| | asnS | asparaginyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (431 aa) |
| | TK0686 | Hydrolase, HAD superfamily. (242 aa) |
| | TK0649 | Putative tRNA-binding protein. (241 aa) |
| | rpl37ae | LSU ribosomal protein L37AE. (86 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily. (375 aa) |
| | TK0561 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (454 aa) |
| | TK0556 | Translation initiation factor eIF-2B, beta subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (356 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (481 aa) |
| | TK0544 | Molybdenum cofactor biosynthesis protein B. (170 aa) |
| | TK0541 | Molybdenum cofactor biosynthesis protein MoeA. (396 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa) |
| | coaBC | Phosphopantothenoylcysteine synthetase/decarboxylase; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Is specific for tRNA(Asp) since it aspartylates tRNA(Asn) 3 orders of magnitude less efficiently than tRNA(Asp); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. (438 aa) |
| | TK0477 | Hydrolase, HAD superfamily. (217 aa) |
| | TK0475 | Bifunctional D-arabino 3-hexulose-6-phosphate formaldehyde lyase/phosphohexuloisomerase. (406 aa) |
| | TK0474 | Arginase; Belongs to the arginase family. (244 aa) |
| | cysS | cysteinyl-tRNA synthetase. (476 aa) |
| | TK0435 | Phosphomethylpyrimidine kinase, fused to C-terminal uncharacterized domain. (431 aa) |
| | thi4 | Thiazole biosynthetic enzyme Thi4; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (251 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (428 aa) |
| | purC-2 | Phosphoribosylaminoimidazolesuccinocarboxamide synthase; Belongs to the SAICAR synthetase family. (219 aa) |
| | TK0431 | Hypothetical protein, conserved, containing DUF1246 and DUF1297 domains. (310 aa) |
| | purO | Inosine 5'-monophosphate cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. (198 aa) |
| | ribH | Riboflavin synthase, beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (156 aa) |
| | ribA | Riboflavin biosynthesis protein RibA; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (386 aa) |
| | TK0425 | Riboflavin synthase, alpha subunit. (184 aa) |
| | TK0424 | Riboflavin biosynthesis protein RibD; Bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminas/5-amino-6-(5-phosphoribosylamino)uracil reductase. (353 aa) |
| | serK | Chromosome partitioning protein ParB homolog; Free serine kinase that uses ADP to phosphorylate L-serine to yield O-phospho-L-serine and AMP. (242 aa) |
| | thiI | Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (381 aa) |
| | TK0364 | Dolichol-phosphate mannosyltransferase. (221 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (284 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (156 aa) |
| | fusA | Translation elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF- [...] (732 aa) |
| | tuf | Translation elongation factor EF-1, alpha subunit; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (428 aa) |
| | rps10 | SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (225 aa) |
| | TK0303 | Membrane-bound metal-dependent hydrolase. (583 aa) |
| | TK0297 | Quinolinate synthetase B; Catalyzes the oxidation of L-aspartate to iminoaspartate. (466 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (302 aa) |
| | mptE | Hypothetical protein, conserved, DUF115 family; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (231 aa) |
| | TK0283 | Homocitrate synthase. (361 aa) |
| | leuC | Homoaconitase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (380 aa) |
| | leuD | Homoaconitase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | TK0280 | Homoisocitrate dehydrogenase. (347 aa) |
| | TK0278 | RimK-related lysine biosynthesis protein. (273 aa) |
| | lysY | N2-acetyl-aminoadipyl-delta-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (330 aa) |
| | lysZ | N2-acetyl-aminoadipate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (251 aa) |
| | lysJ | N2-acetyl-lysine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways. (362 aa) |
| | lysK | N2-acetyl-lysine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (344 aa) |
| | TK0273 | Pyrroline-5-carboxylate reductase, flame shift. (153 aa) |
| | TK0272 | Pyrroline-5-carboxylate reductase, flame shift. (103 aa) |
| | TK0268 | 2-dehydro-3-deoxyphosphoheptonate aldolase. (304 aa) |
| | aroB | 3-dehydroquinate synthetase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (341 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (213 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | aroK | Archaeal shikimate kinase. (271 aa) |
| | aroA | 5-enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (399 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (355 aa) |
| | TK0259 | Prephenate dehydrogenase. (256 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (251 aa) |
| | trpB1 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (389 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (208 aa) |
| | trpG | Anthranilate synthase, component II; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concen [...] (192 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (433 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (325 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (227 aa) |
| | hisC | Histidinol-phosphate aminotransferase. (336 aa) |
| | hisI | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (209 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase, cyclase subunit F; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. (233 aa) |
| | hisH | Imidazoleglycerol-phosphate synthase, subunit H; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (195 aa) |
| | TK0245 | Imidazoleglycerol-phosphate dehydratase. (177 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (376 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (203 aa) |
| | TK0242 | ATP phosphoribosyltransferase, predicted regulatory subunit. (293 aa) |
| | TK0240 | Arginase; Belongs to the arginase family. (273 aa) |
| | TK0239 | Putative tRNA-binding protein. (109 aa) |
| | TK0218 | Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (277 aa) |
| | pdxS | Pyridoxine/pyridoxal 5-phosphate biosynthesis protein, SOR/SNZ family; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (335 aa) |
| | pdxT | Pyridoxine biosynthesis amidotransferase, SNO family; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (197 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (449 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (235 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (334 aa) |
| | purT | Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (429 aa) |
| | purD | Phosphoribosylamine-glycine ligase. (431 aa) |
| | TK0203 | Hypothetical protein, conserved, containing DUF1246 and DUF1297 domains. (380 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, PurS component; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thoug [...] (80 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (223 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (713 aa) |
| | purP | Hypothetical protein, conserved, containing DUF1246 and DUF1297 domains; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. (331 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa) |
| | guaAB | GMP synthase, PP-loop-ATPase component; Catalyzes the synthesis of GMP from XMP. (307 aa) |
| | guaAA | GMP synthase, glutamine amidotransferase component; Catalyzes the synthesis of GMP from XMP. (188 aa) |
| | TK0185 | Translation initiation factor eIF-2B, delta subunit; Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Only accepts the alpha-anomer of D-ribose 1,5-bisphosphate as substrate, being inactive on the beta-anomer. Displays a strict substrate specificity, since other phosphorylated sugars such as R5P, ribose, G16P, G6P, G1P, FBP, F6P, and PRPP, are not substrates. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO. (322 aa) |
| | taw3-1 | Hypothetical protein, conserved, DUF207 family; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. (198 aa) |
| | speE | Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to agmatine to yield N1- aminopropylagmatine. It can also use cadaverine (1,5-diaminopentane) and putrescine (1,4-diaminobutane) as substrate with a lower activity than that of agmatine. The [...] (288 aa) |
| | ef1b | Translation elongation factor EF-1, beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (91 aa) |
| | TK0067 | Nicotinamide mononucleotide adenylyltransferase. (188 aa) |
| | TK0052 | Phosphoserine phosphatase. (209 aa) |
