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hisF hisF hisA hisA TK0218 TK0218 pdxS pdxS guaB guaB TK0852 TK0852 TK0720 TK0720 TK0703 TK0703 TK0675 TK0675 TK1574 TK1574 taw1 taw1 TK1676 TK1676 TK1766 TK1766 TK1807 TK1807 deoC deoC TK2109 TK2109 TK2114 TK2114 tpiA tpiA TK2145 TK2145 TK2160 TK2160 moaA moaA TK2248 TK2248 pyrD pyrD pyrF pyrF TK2299 TK2299 TK0475 TK0475 TK0290 TK0290 TK0283 TK0283 TK0268 TK0268 aroD aroD trpA trpA trpF trpF trpC trpC TK0893 TK0893 fba fba TK0990 TK0990 TK1064 TK1064 queE queE TK1228 TK1228 dapAL dapAL fni fni
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisFImidazoleglycerol-phosphate synthase, cyclase subunit F; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa)
hisA1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. (233 aa)
TK0218Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (277 aa)
pdxSPyridoxine/pyridoxal 5-phosphate biosynthesis protein, SOR/SNZ family; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (335 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa)
TK0852Hypothetical protein, conserved, radical SAM superfamily. (262 aa)
TK0720Hypothetical protein, conserved. (133 aa)
TK0703Hypothetical protein, conserved, radical SAM superfamily. (315 aa)
TK0675Hypothetical protein, conserved, radical SAM superfamily. (445 aa)
TK1574Histone acetyltransferase Elp3 homolog. (595 aa)
taw1Hypothetical protein, conserved, radical SAM superfamily; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (333 aa)
TK1676Nicotinate-nucleotide pyrophosphorylase. (390 aa)
TK1766Hypothetical protein, conserved, radical SAM superfamily. (361 aa)
TK1807Hypothetical protein, conserved, radical SAM superfamily. (302 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. Could be involved in pentose biosynthesis. Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (224 aa)
TK2109Biotin synthase-related protein, radical SAM superfamily. (279 aa)
TK2114Hypothetical protein, conserved. (310 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (226 aa)
TK2145Hypothetical protein, conserved, radical SAM superfamily. (590 aa)
TK2160Hypothetical protein, conserved, radical SAM superfamily. (443 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (307 aa)
TK2248Biotin synthase-related protein, radical SAM superfamily. (312 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (302 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (213 aa)
TK2299Anaerobic ribonucleoside-triphosphate reductase activating enzyme. (236 aa)
TK0475Bifunctional D-arabino 3-hexulose-6-phosphate formaldehyde lyase/phosphohexuloisomerase. (406 aa)
TK0290Pyruvate-formate lyase-activating enzyme. (306 aa)
TK0283Homocitrate synthase. (361 aa)
TK02682-dehydro-3-deoxyphosphoheptonate aldolase. (304 aa)
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (213 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (251 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (208 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (227 aa)
TK0893Pyruvate fromate-lyase activating enzyme-related protein, radical SAM superfamily. (349 aa)
fbaDhnA-type fructose-1,6-bisphosphate aldolase; Belongs to the DeoC/FbaB aldolase family. (281 aa)
TK0990Oxaloacetate decarboxylase, alpha subunit. (595 aa)
TK1064Predicted metallocofactor modifying protein, radical SAM superfamily. (383 aa)
queEOrganic radical activating enzyme, radical SAM superfamily; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (253 aa)
TK1228Probable molybdenum cofactor biosynthesis protein A. (419 aa)
dapALProbable dihydrodipicolinate synthase; Belongs to the DapA family. (292 aa)
fniIsopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (374 aa)
Your Current Organism:
Thermococcus kodakarensis
NCBI taxonomy Id: 69014
Other names: Pyrococcus sp. (strain KOD1), Pyrococcus sp. KOD1, T. kodakarensis KOD1, Thermococcus kodakaraensis KOD1, Thermococcus kodakarensis KOD1, Thermococcus kodakarensis str. KOD1, Thermococcus kodakarensis strain KOD1
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