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| | TK1737 | Xanthine/guanine phosphoribosyltransferase. (154 aa) |
| | cca | tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (456 aa) |
| | TK1784 | Predicted SAM-dependent methyltransferase, DUF890 family. (248 aa) |
| | TK1785 | Probable tRNA/rRNA methyltransferase. (396 aa) |
| | priS | Eukaryotic-type DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after p [...] (346 aa) |
| | TK1809 | 4-alpha-Glucanotransferase, GH57 family. (653 aa) |
| | TK1810 | Cytidylyltransferase. (209 aa) |
| | TK1828 | Galactose-1-phosphate uridylyltransferase. (326 aa) |
| | galK | Galactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (350 aa) |
| | TK1843 | Carbohydrate/pyrimidine kinase, PfkB family; Involved in nucleoside degradation. Phosphorylates cytidine to CMP. Can also act on deoxycytidine and uridine, but is most active with cytidine. ATP is the most preferred phosphate donor, but it can also use GTP, CTP or UTP; Belongs to the carbohydrate kinase PfkB family. (278 aa) |
| | TK1863 | Predicted N6-adenine-specific DNA methylase. (365 aa) |
| | nnrE | YjeF-ralted probable carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow th [...] (480 aa) |
| | TK1893 | Glycerate kinase-related protein, containing MOFRL domain (C-terminus). (248 aa) |
| | mtnP | Purine-nucleoside phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (257 aa) |
| | polB | DNA polymerase II, small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (735 aa) |
| | polC | DNA polymerase II, large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity). (1798 aa) |
| | taw3-2 | Hypothetical protein, conserved, DUF207 family; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. (212 aa) |
| | TK1909 | Dolichol-phosphate mannosyltransferase, fused to membrane-bound GtrA-like domain. (352 aa) |
| | TK1917 | Predicted SAM-dependent methyltransferase. (263 aa) |
| | TK1928 | Diphthine synthase, DPH2 subunit; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. (341 aa) |
| | TK1933 | Predicted DNA methylase. (209 aa) |
| | TK1935 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (450 aa) |
| | TK1956 | Hypothetical protein, conserved, containing ATP/GTP-binding site motif A; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA (By similarity). (351 aa) |
| | TK1957 | 4-hydroxybenzoate octaprenyltransferase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (277 aa) |
| | TK1970 | Probable tRNA/rRNA methyltransferase, SpoU family. (235 aa) |
| | ogt | methylated-DNA-protein-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family. (174 aa) |
| | TK1994 | Nucleotidyltransferase. (108 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (201 aa) |
| | TK2029 | Carbohydrate/pyrimidine kinase, PfkB family; Involved in nucleoside degradation. Phosphorylates ribose 1- phosphate (R1P) to ribose 1,5-bisphosphate. Can also act on deoxyribose 1-phosphate (dR1P), but is most active with R1P. ADP is the most preferred phosphate donor, followed by GDP and UDP. Belongs to the carbohydrate kinase PfkB family. (294 aa) |
| | gcvT | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (398 aa) |
| | TK2045 | SAM-dependent methyltransferase, UPF0020 family. (290 aa) |
| | TK2101 | Aminotransferase, class III; L-ornithine aminotransferase involved in L-proline biosynthesis. Also shows high activity toward L-lysine. 2-oxoglutarate is the best amino acceptor, but 2-oxoadipate also leads to moderate activity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa) |
| | carS | Hypothetical membrane protein, conserved, DUF46 family; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (171 aa) |
| | TK2122 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family, containing RNA-binding PUA domain; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (383 aa) |
| | nadK | ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (278 aa) |
| | kae1 | O-Sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (325 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. (165 aa) |
| | TK2130 | ATP:corrinoid adenosyltransferase. (175 aa) |
| | TK2135 | 23S rRNA (uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (417 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (185 aa) |
| | TK2141 | GHMP kinase; Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. Displays broad nucleotide specificity and utilizes ATP, GTP, UTP, and CTP with comparable catalytic efficiencies. (300 aa) |
| | cpkA | Carbamate kinase-like carbamoyl phosphate synthetase. (315 aa) |
| | Tk-cgt | Cyclodextrin glucanotransferase, GH13 family. (713 aa) |
| | TK2192 | dephospho-CoA kinase. (195 aa) |
| | pyrB | Aspartate carbamoyltransferase, catalytic subunit. (310 aa) |
| | TK2214 | Ribosomal protein-alanine acetyltransferase RimI homolog. (166 aa) |
| | prs | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). It can also use CTP and GTP as substrates in addition to ATP. (280 aa) |
| | TK2241 | SAM-dependent methyltransferase, UbiE/COQ5 family. (228 aa) |
| | TK2242 | GHMP kinase; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P). (318 aa) |
| | TK2250 | Serine/threonine protein kinase, RIO1 family. (311 aa) |
| | TK2254 | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase. (298 aa) |
| | TK2255 | Bifunctional phosphatase/dolichol-phosphate glucosyltransferase. (440 aa) |
| | TK2268 | Aspartate aminotransferase. (392 aa) |
| | ribL | Glycerol-3-phosphate cytidylyltransferase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (149 aa) |
| | TK2279 | Bifunctional sugar nucleotidyltransferase/CDP-alcohol phosphatidyltransferase synthase; Involved in biosynthesis of di-myo-inositol phosphate (DIP), a widespread organic solute in microorganisms adapted to hot environments. Catalyzes the condensation of CTP and L-myo-inositol-1- phosphate into CDP-L-myo-inositol, as well as the biosynthesis of di- myo-inositol-1,3'-phosphate-1'-phosphate (DIPP) from CDP-L-myo-inositol and L-myo-inositol-1-phosphate; In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family. (432 aa) |
| | TK2285 | Carbohydrate/pyrimidine kinase, PfkB family. (273 aa) |
| | TK2304 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family, fused to N-terminal NusB regulator domain; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (450 aa) |
| | TK1293 | Putative membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase. (825 aa) |
| | TK1301 | Probable ATP-NAD kinase. (381 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (174 aa) |
| | tdk | Thymidine kinase. (197 aa) |
| | TK1323 | Glycosyltransferase, family 4. (384 aa) |
| | TK1324 | 4-hydroxybenzoate octaprenyltransferase. (264 aa) |
| | TK1328 | tRNA (1-methyladenosine) methyltransferase. (253 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. Can utilize other nucleoside triphosphates (GTP, CTP, UTP AND ITP) as a phosphoryl donor; Belongs to the FGGY kinase family. (497 aa) |
| | tmk | Thymidylate kinase. (205 aa) |
| | dnaG | DnaG-related protein, containing Toprim domain; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (464 aa) |
| | TK1436 | Probable alpha-amylase, GH57 family; Catalyzes the formation of branch points in alpha-glucans by cleavage of an alpha-1,4 glycosidic bond and subsequent transfer of the cleaved-off oligosaccharide to a new alpha-1,6 position. The branch chain-length distribution of the reaction products shows degree of polymerization (DP) of 5 to 30, with two local maxima at DP 6 and DP 11. Exhibits an alpha-retaining catalytic mechanism. Does not display alpha-galactosidase or pullulanase activity, since melibiose and pullulan are not substrates. Is not able to catalyze the hydrolysis or transglycosy [...] (675 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (292 aa) |
| | TK1445 | Aspartokinase. (366 aa) |
| | metE | Methionine synthase II (cobalamin-independent); Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown (By similarity). (336 aa) |
| | TK1460 | Predicted endonuclease-methyltransferase fusion protein. (1282 aa) |
| | idsA | Bifunctional short-chain isoprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (343 aa) |
| | TK1473 | Amino acid kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. (262 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (337 aa) |
| | TK1476 | Nucleotidyltransferase. (124 aa) |
| | TK1479 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (277 aa) |
| | TK1482 | Purine-nucleoside phosphorylase; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. (267 aa) |
| | TK1489 | Adenine phosphoribosyltransferase, fused to N-terminal DNA-binding domain. (237 aa) |
| | rpoK | DNA-directed RNA polymerase, subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (57 aa) |
| | rpoN | DNA-directed RNA polymerase subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (65 aa) |
| | rpoD | DNA-directed RNA polymerase, subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. (259 aa) |
| | TK1507 | Ribosomal RNA small subunit methyltransferase C. (195 aa) |
| | cmk | Cytidylate kinase. (193 aa) |
| | adkA | Archaeal adenylate kinase; Belongs to the archaeal adenylate kinase family. (196 aa) |
| | TK1548 | Probable serine--glyoxylate aminotransferase, class V. (385 aa) |
| | TK1554 | Glycosyltransferase, family 2. (426 aa) |
| | TK1574 | Histone acetyltransferase Elp3 homolog. (595 aa) |
| | TK1673 | N5-glutamine methyltransferase, HemK family. (194 aa) |
| | bpsA | Hypothetical protein, conserved, DUF43 family; Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine. Can also use spermine to produce N(4)-aminopropylspermine. (351 aa) |
| | TK1697 | Hypothetical protein, conserved, DUF359 family; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). Can also use UTP, with lower efficiency and has weak activity with ATP, but shows a strong preference for GTP as the phosphate donor. (177 aa) |
| | TK1709 | Nucleotidyltransferase. (135 aa) |
| | TK1711 | Sugar-phosphate nucleotydyltransferase. (331 aa) |
| | TK1713 | Glycosyltransferase, family 4. (357 aa) |
| | TK1714 | Glycosyltransferase, family 2. (323 aa) |
| | TK1715 | CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase. (397 aa) |
| | TK1716 | Cytidylyltransferase. (229 aa) |
| | TK1717 | Glycosyltransferase, family 2. (294 aa) |
| | TK1718 | Oligosaccharyl transferase, STT3 subunit. (766 aa) |
| | TK1720 | Dolichol-phosphate mannosyltransferase. (241 aa) |
| | TK1721 | Glycosyltransferase, family 4. (359 aa) |
| | TK1722 | Probable beta-1,3-galactosyltransferase. (272 aa) |
| | TK1723 | Glycosyltransferase, family 4. (388 aa) |
| | TK1731 | Glycosyltransferase, family 4. (353 aa) |
| | TK1732 | Dolichol-phosphate mannosyltransferase, fused to C-terminal uncharacterized domain. (373 aa) |
| | pol | DNA-directed DNA polymerase, family B; Intein encoded endonucleases are thought to mediate intein mobility by site-specific recombination initiated by endonuclease cleavage at the 'homing site' in gene that lack the intein. PI-PkoI recognizes 5'-GATTTAGATCCCTGTACC-3' and PI-PkoII recognizes 5'- CAGCTACTACGGTTAC-3'. (1671 aa) |
| | TK0008 | Predicted DNA methylase. (366 aa) |
| | TK0037 | SAM-dependent methyltransferase, UbiE/COQ5 family. (319 aa) |
| | TK0051 | protein-L-isoaspartate carboxylmethyltransferase, flame shift. (170 aa) |
| | TK0059 | CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (189 aa) |
| | TK0060 | Hypothetical protein, conserved, DUF127 family; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. (180 aa) |
| | TK0063 | Nucleotidyltransferase, fused to N-terminal DNA-binding domain. (182 aa) |
| | TK0067 | Nicotinamide mononucleotide adenylyltransferase. (188 aa) |
| | taw2 | Met-10+ like protein; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). (278 aa) |
| | dphB | Diphthine synthase, methylase subunit; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. (264 aa) |
| | TK0125 | N-acetyltransferase, GNAT family. (169 aa) |
| | speE | Spermidine synthase; Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high- temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to agmatine to yield N1- aminopropylagmatine. It can also use cadaverine (1,5-diaminopentane) and putrescine (1,4-diaminobutane) as substrate with a lower activity than that of agmatine. The [...] (288 aa) |
| | TK0153 | ATP:dephospho-CoA triphosphoribosyl transferase. (308 aa) |
| | taw3-1 | Hypothetical protein, conserved, DUF207 family; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. (198 aa) |
| | TK0180 | acetyl-CoA acetyltransferase. (388 aa) |
| | flpA | snoRNP component, Fibrillarin homolog; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (226 aa) |
| | TK0186 | Multiple substrate aminotransferase. (417 aa) |
| | TK0187 | Predicted glutamine amidotransferase, class I. (283 aa) |
| | purT | Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (429 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (449 aa) |
| | TK0218 | Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (277 aa) |
| | TK0219 | Sugar-phosphate nucleotidyltransferase. (413 aa) |
| | TK0222 | Nucleotidyltransferase. (122 aa) |
| | TK0224 | SAM-dependent methyltransferase, UbiE/COQ5 family. (207 aa) |
| | TK0232 | N-acetyltransferase, GNAT family. (273 aa) |
| | TK0233 | Ribosomal protein-serine acetyltransferase RimL homolog. (193 aa) |
| | TK0234 | Predicted SAM-dependent methyltransferase. (206 aa) |
| | TK0242 | ATP phosphoribosyltransferase, predicted regulatory subunit. (293 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (203 aa) |
| | hisC | Histidinol-phosphate aminotransferase. (336 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (325 aa) |
| | aspC | Probable aromatic aminotransferase; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (364 aa) |
| | aroA | 5-enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (399 aa) |
| | aroK | Archaeal shikimate kinase. (271 aa) |
| | lysJ | N2-acetyl-lysine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways. (362 aa) |
| | lysZ | N2-acetyl-aminoadipate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (251 aa) |
| | mptE | Hypothetical protein, conserved, DUF115 family; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (231 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (302 aa) |
| | kptA | RNA 2'-phosphotransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase. (180 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (225 aa) |
| | TK0329 | Lysine/arginine/ornithine transport system kinase. (319 aa) |
| | TK0331 | N-acetyltransferase, GNAT family. (283 aa) |
| | TK0338 | Predicted nucleotide kinase, related to CMP and AMP kinases; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (177 aa) |
| | TK0341 | Nucleotidyltransferase, fused to N-terminal DNA-binding domain. (202 aa) |
| | deoA | Thymidine phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP, dCMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. (503 aa) |
| | TK0360 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (312 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (284 aa) |
| | TK0364 | Dolichol-phosphate mannosyltransferase. (221 aa) |
| | thiI | Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (381 aa) |
| | pfkC | ADP-dependent phosphofructokinase; Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor. (461 aa) |
| | serK | Chromosome partitioning protein ParB homolog; Free serine kinase that uses ADP to phosphorylate L-serine to yield O-phospho-L-serine and AMP. (242 aa) |
| | TK0422 | tRNA m1G methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of either N(1)-methyladenine or N(1)-methylguanine at position 9 (m1A9 or m1G9) in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family. (370 aa) |
| | TK1733 | Glycosyltransferase, family 1. (369 aa) |
| | ribH | Riboflavin synthase, beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (156 aa) |
| | thi4 | Thiazole biosynthetic enzyme Thi4; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (251 aa) |
| | TK0435 | Phosphomethylpyrimidine kinase, fused to C-terminal uncharacterized domain. (431 aa) |
| | TK0436 | ABC-type transporter, ATPase component, fused to acetyltransferase domain. (633 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate decarboxylase UbiX; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (185 aa) |
| | dacZ | Hypothetical protein, conserved, DUF147 family; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. (266 aa) |
| | pyk | Pyruvate kinase; Belongs to the pyruvate kinase family. (478 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa) |
| | TK0538 | N-acetyltransferase, GNAT family. (177 aa) |
| | mat | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (405 aa) |
| | TK0548 | Aromatic aminotransferase. (389 aa) |
| | TK0549 | Carbamoyl transferase, NodU family. (536 aa) |
| | trmY | Hypothetical protein, conserved, DUF358 family; Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs; Belongs to the methyltransferase superfamily. TrmY family. (198 aa) |
| | TK0591 | Predicted N-acetyltransferase, GNAT family. (335 aa) |
| | rpoP | DNA-directed RNA polymerase, subunit P; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (49 aa) |
| | TK0631 | Chemotaxis protein methyltransferase. (279 aa) |
| | TK0634 | Chemotaxis histidine kinase, flame shift. (548 aa) |
| | TK0635 | Chemotaxis histidine kinase, flame shift. (231 aa) |
| | TK0664 | Hypoxanthine/guanine phosphoribosyltransferase. (215 aa) |
| | dys | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. (337 aa) |
| | TK0674 | Nucleotidyltransferase. (148 aa) |
| | TK0679 | Serine/threonine protein kinase, RIO1 family. (221 aa) |
| | cobB | NAD-dependent protein deacetylase Sir2p homolog; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. (257 aa) |
| | TK0704 | SAM-dependent methyltransferase, UbiE/COQ5 family. (209 aa) |
| | TK0722 | Probable protein-S isoprenylcysteine O-methyltransferase. (143 aa) |
| | TK0729 | SAM-dependent methyltransferase, UbiE/COQ5 family. (200 aa) |
| | tmcA | Predicted ATPase, DUF699 family, fused to acetyltransferase domain; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (811 aa) |
| | tgtA | Archaeosine tRNA-guanine transglycosylase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (580 aa) |
| | TK0762 | Glycosyltransferase, family 2. (350 aa) |
| | TK0801 | Serine/threonine protein kinase Rio1p homolog. (258 aa) |
| | TK0806 | Putative membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase. (452 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (602 aa) |
| | TK0810 | Oligosaccharyl transferase, STT3 subunit. (1000 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (224 aa) |
| | TK0856 | GTP:adenosylcobinamide-phosphate guanylyltransferase. (191 aa) |
| | cobS | Cobalamin-5-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (231 aa) |
| | thyX | Alternative thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (245 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (315 aa) |
| | TK0872 | tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (309 aa) |
| | nep1 | Ribosome biogenesis protein Nep1p homolog, suppressor Mra1 family; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. (220 aa) |
| | thiL | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (309 aa) |
| | TK0891 | Glycosyltransferase, family 4. (387 aa) |
| | rsmA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (279 aa) |
| | TK0939 | GHMP kinase; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P). (324 aa) |
| | TK0945 | Nucleotidyltransferase. (234 aa) |
| | TK0948 | Putative translation factor Sua5p homolog; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (339 aa) |
| | TK0949 | Glycosyltransferase, family 4. (344 aa) |
| | TK0955 | Sugar-phosphate nucleotidyltransferase. (413 aa) |
| | TK0962 | Nucleotidyltransferase. (104 aa) |
| | trm1 | N2,N2-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (376 aa) |
| | TK0981 | N2, N2-dimethylguanosine tRNA methyltransferase. (331 aa) |
| | TK1026 | Geranylgeranylglyceryl diphosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids; Belongs to the GGGP/HepGP synthase family. Group II subfamily. (252 aa) |
| | TK1035 | Predicted glutamine amidotransferase, class II. (267 aa) |
| | pgk2 | 2-phosphoglycerate kinase. (290 aa) |
| | TK1045 | Cobalamin adenosyltransferase. (171 aa) |
| | TK1054 | N-acetyltransferase, GNAT family. (177 aa) |
| | TK1073 | Nucleotidyltransferase. (101 aa) |
| | rpoA2 | DNA-directed RNA polymerase, subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (391 aa) |
| | TK1082 | DNA-directed RNA polymerase, subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (906 aa) |
| | TK1083 | DNA-directed RNA polymerase, subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1123 aa) |
| | rpoH | DNA-directed RNA polymerase, subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (82 aa) |
| | TK1094 | Alanine aminotransferase. (399 aa) |
| | TK1109 | Bifunctional mannose-6-phosphate isomerase/mannose-1-phosphate guanylyl transferase; Belongs to the mannose-6-phosphate isomerase type 2 family. (465 aa) |
| | glkA | ADP-dependent glucokinase; Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate. Involved in chitin degradation. (453 aa) |
| | TK1116 | 23S rRNA (uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (421 aa) |
| | TK1128 | Nucleotidyltransferase. (94 aa) |
| | pgk | 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (411 aa) |
| | TK1158 | Predicted endonuclease-methyltransferase fusion protein. (1125 aa) |
| | rpoL | DNA-directed RNA polymerase, subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. (94 aa) |
| | uppS | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids. (264 aa) |
| | TK1174 | Predicted acetyltransferase, isoleucine patch superfamily. (173 aa) |
| | TK1188 | Sugar-phosphate nucleotydyltransferase. (419 aa) |
| | TK1211 | Aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (443 aa) |
| | ribK | Predicted transcription regulator, containing Crp and DUF120 domains; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (211 aa) |
| | TK1273 | SAM-dependent methyltransferase, UbiE/COQ5 family. (249 aa) |
| | upp | Uracilphosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (230 aa) |
| | TK1292 | Phosphoenolpyruvate synthetase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (793 aa) |
