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| | TK0052 | Phosphoserine phosphatase. (209 aa) |
| | TK0242 | ATP phosphoribosyltransferase, predicted regulatory subunit. (293 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (203 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (376 aa) |
| | TK0245 | Imidazoleglycerol-phosphate dehydratase. (177 aa) |
| | hisH | Imidazoleglycerol-phosphate synthase, subunit H; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (195 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. (233 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase, cyclase subunit F; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisI | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (209 aa) |
| | hisC | Histidinol-phosphate aminotransferase. (336 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (227 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (325 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (433 aa) |
| | trpG | Anthranilate synthase, component II; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concen [...] (192 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (208 aa) |
| | trpB1 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (389 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (251 aa) |
| | TK0259 | Prephenate dehydrogenase. (256 aa) |
| | aspC | Probable aromatic aminotransferase; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (364 aa) |
| | TK0261 | Predicted chorismate mutase, N-truncation. (58 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (355 aa) |
| | aroA | 5-enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (399 aa) |
| | aroK | Archaeal shikimate kinase. (271 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (213 aa) |
| | aroB | 3-dehydroquinate synthetase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (341 aa) |
| | TK0268 | 2-dehydro-3-deoxyphosphoheptonate aldolase. (304 aa) |
| | TK0269 | Transketolase, C-terminal section. (306 aa) |
| | TK0270 | Transketolase, N-terminal section. (219 aa) |
| | TK0272 | Pyrroline-5-carboxylate reductase, flame shift. (103 aa) |
| | TK0273 | Pyrroline-5-carboxylate reductase, flame shift. (153 aa) |
| | lysK | N2-acetyl-lysine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (344 aa) |
| | lysJ | N2-acetyl-lysine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways. (362 aa) |
| | lysZ | N2-acetyl-aminoadipate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (251 aa) |
| | lysY | N2-acetyl-aminoadipyl-delta-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (330 aa) |
| | TK0278 | RimK-related lysine biosynthesis protein. (273 aa) |
| | TK0280 | Homoisocitrate dehydrogenase. (347 aa) |
| | leuD | Homoaconitase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | leuC | Homoaconitase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (380 aa) |
| | TK0283 | Homocitrate synthase. (361 aa) |
| | TK0313 | ArgE/DapE-related deacylase. (362 aa) |
| | pfkC | ADP-dependent phosphofructokinase; Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor. (461 aa) |
| | TK0475 | Bifunctional D-arabino 3-hexulose-6-phosphate formaldehyde lyase/phosphohexuloisomerase. (406 aa) |
| | pyk | Pyruvate kinase; Belongs to the pyruvate kinase family. (478 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa) |
| | mat | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (405 aa) |
| | TK0551 | D-isomer specific 2-hydroxyacid dehydrogenase. (333 aa) |
| | TK0672 | Glutamate synthase beta chain-related oxidoreductase. (348 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). (334 aa) |
| | TK0864 | threonine-O-3-phosphate decarboxylase. (322 aa) |
| | apgM | 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (411 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (315 aa) |
| | TK0950 | Asparagine synthase (glutamine-hydrolyzing). (483 aa) |
| | fba | DhnA-type fructose-1,6-bisphosphate aldolase; Belongs to the DeoC/FbaB aldolase family. (281 aa) |
| | TK0990 | Oxaloacetate decarboxylase, alpha subunit. (595 aa) |
| | TK1094 | Alanine aminotransferase. (399 aa) |
| | glkA | ADP-dependent glucokinase; Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate. Involved in chitin degradation. (453 aa) |
| | pgk | 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (411 aa) |
| | dapAL | Probable dihydrodipicolinate synthase; Belongs to the DapA family. (292 aa) |
| | TK1325 | ferredoxin:NADP oxidoreductase, alpha subunit. (481 aa) |
| | rpiA | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (229 aa) |
| | trpB2 | Tryptophan synthase beta subunit-related protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (442 aa) |
| | TK1443 | Aspartate-semialdehyde dehydrogenase. (335 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (292 aa) |
| | TK1445 | Aspartokinase. (366 aa) |
| | metE | Methionine synthase II (cobalamin-independent); Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown (By similarity). (336 aa) |
| | TK1447 | Methionine synthase II (cobalamin-independent). (309 aa) |
| | TK1449 | Cystathionine gamma-synthase. (366 aa) |
| | TK1466 | ArgE/DapE-related deacylase. (439 aa) |
| | TK1478 | Threonine synthase. (354 aa) |
| | TK1497 | Enolase-related protein. (341 aa) |
| | TK1627 | Homoserine dehydrogenase. (334 aa) |
| | TK1684 | ferredoxin:NADP oxidoreductase, alpha subunit. (481 aa) |
| | TK1687 | Cysteine synthase. (273 aa) |
| | TK1781 | ArgE/DapE-related deacylase. (422 aa) |
| | glnA | Glutamine synthetase; Carries out the ATP-dependent synthesis of glutamine from ammonium nitrogen and glutamate. Exhibits both L-gamma- glutamylhydroxamate synthetase and gamma-glutamyltransferase activities when using hydroxylamine as substrate; in fact, the enzyme possesses low biosynthetic activity, suggesting that the reaction is biased towards the degradation of glutamine under ammonia-rich conditions. Might play some role in ammonia assimilation under ammonia-starvation conditions. Can also use GTP instead of ATP in the synthetase reaction, but not CTP or UTP. (443 aa) |
| | TK1966 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (304 aa) |
| | TK2074 | Glutamate synthase beta chain-related oxidoreductase. (351 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (226 aa) |
| | TK2163 | Tungsten-containing glyceraldehyde-3-phosphate:ferredoxin oxidoreductase. (652 aa) |
| | fbp | Thermophile-specific fructose-1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). Does not display hydrolase activity against fructose 2,6-bisphosphate, fructose 6-phosphate, fructose 1- phosphate, glucose 6-phosphate, and glucose 1-phosphate. Exhibits only negligible activity on inositol-1- phosphate (IMP). Is essential for the growth of T.kodakaraensis under gluconeogen [...] (375 aa) |
| | TK2205 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (381 aa) |
| | prs | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). It can also use CTP and GTP as substrates in addition to ATP. (280 aa) |
| | TK2268 | Aspartate aminotransferase. (392 aa) |
