STRINGSTRING
ilvC ilvC Desaf_2664 Desaf_2664 Desaf_2778 Desaf_2778 dapB dapB dapB-2 dapB-2 hemA hemA asd asd proA proA Desaf_0088 Desaf_0088 zwf zwf Desaf_0187 Desaf_0187 Desaf_0246 Desaf_0246 Desaf_0269 Desaf_0269 Desaf_3649 Desaf_3649 Desaf_0287 Desaf_0287 Desaf_0534 Desaf_0534 Desaf_0754 Desaf_0754 Desaf_0812 Desaf_0812 fcl fcl gmd gmd aroE aroE hldD hldD Desaf_1496 Desaf_1496 Desaf_2258 Desaf_2258 Desaf_2344 Desaf_2344 Desaf_2392 Desaf_2392 Desaf_2530 Desaf_2530 dxr dxr
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa)
Desaf_2664PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; KEGG: dsa:Desal_2440 homoserine dehydrogenase. (429 aa)
Desaf_27783-hydroxyisobutyrate dehydrogenase; KEGG: sbi:SORBI_03g025830 hypothetical protein; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding protein. (291 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (261 aa)
dapB-2Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (261 aa)
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (450 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (341 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (419 aa)
Desaf_00886-phosphogluconate dehydrogenase, decarboxylating; TIGRFAM: 6-phosphogluconate dehydrogenase related protein; KEGG: drt:Dret_2486 6-phosphogluconate dehydrogenase, decarboxylating; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding; 6-phosphogluconate dehydrogenase, C-terminal. (302 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (523 aa)
Desaf_0187TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: dma:DMR_28790 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa)
Desaf_0246KEGG: C_GCAxxG_C_C family protein; TIGRFAM: CGCAxxGCC motif; PFAM: CGCAxxGCC motif. (159 aa)
Desaf_0269TIGRFAM: Flavoprotein WrbA; HAMAP: Flavoprotein wrbA; KEGG: sfu:Sfum_3387 TrpR binding protein WrbA; PFAM: Flavodoxin/nitric oxide synthase. (203 aa)
Desaf_3649PFAM: NADPH-dependent FMN reductase; KEGG: mac:MA0327 iron-sulfur flavoprotein. (191 aa)
Desaf_0287PFAM: 6-phosphogluconate dehydrogenase, NAD-binding protein; KEGG: dae:Dtox_1550 6-phosphogluconate dehydrogenase NAD-binding. (236 aa)
Desaf_0534PFAM: NADPH-dependent FMN reductase; KEGG: geo:Geob_0527 NADPH-dependent FMN reductase. (218 aa)
Desaf_0754Glutathione-disulfide reductase; KEGG: nca:Noca_1648 pyridine nucleotide-disulphide oxidoreductase dimerisation region; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. (448 aa)
Desaf_0812TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: dma:DMR_28790 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa)
fclGDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (316 aa)
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (386 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (305 aa)
hldDADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (328 aa)
Desaf_1496PFAM: 6-phosphogluconate dehydrogenase, NAD-binding protein; KEGG: tro:trd_1142 6-phosphogluconate dehydrogenase-like protein. (238 aa)
Desaf_2258PFAM: NADPH-dependent FMN reductase; KEGG: sfu:Sfum_0893 NADPH-dependent FMN reductase. (193 aa)
Desaf_2344Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (380 aa)
Desaf_2392TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: dba:Dbac_0093 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (330 aa)
Desaf_2530PFAM: 6-phosphogluconate dehydrogenase, NAD-binding protein; KEGG: tra:Trad_1969 6-phosphogluconate dehydrogenase. (233 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (423 aa)
Your Current Organism:
Desulfocurvibacter africanus
NCBI taxonomy Id: 690850
Other names: D. africanus subsp. africanus str. Walvis Bay, Desulfocurvibacter africanus str. Walvis Bay, Desulfocurvibacter africanus subsp. africanus str. Walvis Bay, Desulfovibrio africanus ATCC 19997, Desulfovibrio africanus str. Walvis Bay, Desulfovibrio africanus strain Walvis Bay
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.