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Desaf_0187 Desaf_0187 gpmA gpmA acsA acsA eno eno Desaf_0487 Desaf_0487 ldh ldh Desaf_0614 Desaf_0614 Desaf_0721 Desaf_0721 Desaf_0794 Desaf_0794 Desaf_0812 Desaf_0812 Desaf_0850 Desaf_0850 Desaf_1086 Desaf_1086 Desaf_1087 Desaf_1087 pgi pgi Desaf_1160 Desaf_1160 Desaf_1251 Desaf_1251 Desaf_1265 Desaf_1265 Desaf_1391 Desaf_1391 Desaf_1509 Desaf_1509 Desaf_1541 Desaf_1541 Desaf_1542 Desaf_1542 aroA-2 aroA-2 Desaf_2091 Desaf_2091 Desaf_2186 Desaf_2186 Desaf_2280 Desaf_2280 Desaf_2391 Desaf_2391 Desaf_2392 Desaf_2392 Desaf_2414 Desaf_2414 aroA-3 aroA-3 Desaf_2828 Desaf_2828 aroA-4 aroA-4 Desaf_2884 Desaf_2884 Desaf_2887 Desaf_2887 Desaf_2946 Desaf_2946 tpiA tpiA pgk pgk fbp fbp Desaf_3133 Desaf_3133 Desaf_3217 Desaf_3217 gpmI gpmI Desaf_3337 Desaf_3337 eno-2 eno-2 Desaf_3687 Desaf_3687 Desaf_3715 Desaf_3715 Desaf_3716 Desaf_3716 Desaf_3764 Desaf_3764
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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Your Input:
Desaf_0187TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: dma:DMR_28790 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa)
gpmA2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (247 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (663 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (448 aa)
Desaf_0487KEGG: tra:Trad_0749 phosphoglucomutase, alpha-D-glucose phosphate-specific; TIGRFAM: Phosphoglucomutase, alpha-D-glucose specific; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domain III; Alpha-D-phosphohexomutase, C-terminal. (550 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (328 aa)
Desaf_0614KEGG: iron-containing alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, iron-type. (389 aa)
Desaf_0721KEGG: sfu:Sfum_0630 pyruvate, water dikinase; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile region. (858 aa)
Desaf_0794CoA-binding domain protein; PFAM: CoA-binding; ATP-grasp fold, succinyl-CoA synthetase-type; KEGG: CoA-binding domain-containing protein. (697 aa)
Desaf_0812TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: dma:DMR_28790 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa)
Desaf_08506-phosphofructokinase; KEGG: dde:Dde_1589 diphosphate--fructose-6-phosphate 1-phosphotransferase; PFAM: Phosphofructokinase. (448 aa)
Desaf_10863-methyl-2-oxobutanoate dehydrogenase (ferredoxin); KEGG: dsa:Desal_3825 2-ketoisovalerate ferredoxin reductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal. (358 aa)
Desaf_10872-oxoglutarate synthase; KEGG: drt:Dret_0090 thiamine pyrophosphate protein domain protein TPP-binding; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding protein. (255 aa)
pgiHAMAP: Phosphoglucose isomerase (PGI); KEGG: tgr:Tgr7_0871 glucose-6-phosphate isomerase; PFAM: Phosphoglucose isomerase (PGI); Belongs to the GPI family. (547 aa)
Desaf_11606-phosphofructokinase; KEGG: dba:Dbac_0531 diphosphate--fructose-6-phosphate 1-phosphotransferase; PFAM: Phosphofructokinase. (443 aa)
Desaf_1251Butyrate--CoA ligase; KEGG: dma:DMR_19670 putative acetyl-coenzyme A synthetase; PFAM: AMP-dependent synthetase/ligase. (549 aa)
Desaf_1265PFAM: Aldehyde dehydrogenase; KEGG: ava:Ava_3615 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (466 aa)
Desaf_1391acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (639 aa)
Desaf_1509KEGG: glucokinase; PFAM: Glucokinase; Belongs to the bacterial glucokinase family. (316 aa)
Desaf_1541TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit; KEGG: pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase. (564 aa)
Desaf_1542TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate; KEGG: dde:Dde_1793 2-oxoacid:acceptor oxidoreductase subunit beta, pyruvate/2-ketoisovalerate; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding protein. (295 aa)
aroA-2Phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (275 aa)
Desaf_2091Fructose-1,6-bisphosphatase, class II; TIGRFAM: GlpX; KEGG: fructose-1,6-bisphosphatase; PFAM: GlpX. (327 aa)
Desaf_2186TIGRFAM: Pyruvate-flavodoxin oxidoreductase; KEGG: dvl:Dvul_0348 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; Thiamine pyrophosphate enzyme, C-terminal TPP-binding protein. (1232 aa)
Desaf_2280Pyruvate, water dikinase; KEGG: pyruvate phosphate dikinase pEp/pyruvate-binding protein; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile region. (865 aa)
Desaf_2391TIGRFAM: Fructose-1,6-bisphosphate aldolase, class II; Ketose-bisphosphate aldolase, class-II; KEGG: dvl:Dvul_1089 fructose-1,6-bisphosphate aldolase, class II; PFAM: Ketose-bisphosphate aldolase, class-II. (309 aa)
Desaf_2392TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: dba:Dbac_0093 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (330 aa)
Desaf_2414PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domain III; Alpha-D-phosphohexomutase, C-terminal; KEGG: dma:DMR_27100 phosphohexose mutase. (464 aa)
aroA-3Phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (265 aa)
Desaf_2828TIGRFAM: Homoserine kinase, putative; Cofactor-independent phosphoglycerate mutase, archaeal; KEGG: proposed homoserine kinase; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Metalloenzyme. (399 aa)
aroA-4Phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (267 aa)
Desaf_2884Alcohol dehydrogenase; KEGG: dba:Dbac_3326 iron-containing alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, iron-type. (393 aa)
Desaf_2887Alcohol dehydrogenase; KEGG: dvm:DvMF_0330 iron-containing alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, iron-type. (380 aa)
Desaf_2946Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (800 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
pgkHAMAP: Phosphoglycerate kinase; KEGG: dba:Dbac_0879 phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (397 aa)
fbpHAMAP: Fructose-1,6-bisphosphatase; KEGG: dvm:DvMF_0404 fructose-1,6-bisphosphatase; PFAM: Fructose-1,6-bisphosphatase; Belongs to the FBPase class 1 family. (340 aa)
Desaf_3133Pyruvate, water dikinase., Phosphoenolpyruvate--protein phosphotransferase; KEGG: dvm:DvMF_0416 pyruvate phosphate dikinase PEP/pyruvate-binding; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile region; PEP-utilising enzyme. (1198 aa)
Desaf_3217PFAM: Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: pmr:PMI1592 fructose-bisphosphate aldolase. (349 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (525 aa)
Desaf_3337KEGG: sfu:Sfum_0649 pyruvate, water dikinase; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile region. (869 aa)
eno-2Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
Desaf_3687TIGRFAM: Pyruvate kinase; KEGG: dba:Dbac_3014 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; Belongs to the pyruvate kinase family. (473 aa)
Desaf_3715KEGG: dma:DMR_18780 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding protein. (279 aa)
Desaf_37162-oxoglutarate synthase; KEGG: pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal. (383 aa)
Desaf_3764Dihydrolipoyl dehydrogenase; KEGG: FAD-dependent pyridine nucleotide-disulfide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. (452 aa)
Your Current Organism:
Desulfocurvibacter africanus
NCBI taxonomy Id: 690850
Other names: D. africanus subsp. africanus str. Walvis Bay, Desulfocurvibacter africanus str. Walvis Bay, Desulfocurvibacter africanus subsp. africanus str. Walvis Bay, Desulfovibrio africanus ATCC 19997, Desulfovibrio africanus str. Walvis Bay, Desulfovibrio africanus strain Walvis Bay
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