STRINGSTRING
Desaf_0110 Desaf_0110 Desaf_0138 Desaf_0138 kdsB kdsB lpxC lpxC kdsA kdsA gmhA gmhA Desaf_1305 Desaf_1305 hldD hldD Desaf_1502 Desaf_1502 Desaf_1554 Desaf_1554 lpxK lpxK Desaf_2296 Desaf_2296 Desaf_2507 Desaf_2507 Desaf_2590 Desaf_2590 lpxD lpxD lpxA lpxA Desaf_3022 Desaf_3022 Desaf_3023 Desaf_3023 Desaf_3173 Desaf_3173 Desaf_3253 Desaf_3253 Desaf_3659 Desaf_3659
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Desaf_0110KpsF/GutQ family protein; SMART: Cystathionine beta-synthase, core; TIGRFAM: KpsF/GutQ; KEGG: drt:Dret_0322 KpsF/GutQ family protein; PFAM: Sugar isomerase (SIS); Cystathionine beta-synthase, core; Belongs to the SIS family. GutQ/KpsF subfamily. (330 aa)
Desaf_0138Three-deoxy-D-manno-octulosonic-acid transferase domain-containing protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (427 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (253 aa)
lpxCUDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (307 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; TIGRFAM: 3-deoxy-8-phosphooctulonate synthase; HAMAP: 3-deoxy-8-phosphooctulonate synthase; KEGG: mgm:Mmc1_1558 2-dehydro-3-deoxyphosphooctonate aldolase. (279 aa)
gmhAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (205 aa)
Desaf_1305PFAM: Protein of unknown function DUF2219; KEGG: dde:Dde_2623 hypothetical protein. (341 aa)
hldDADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (328 aa)
Desaf_1502lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (380 aa)
Desaf_1554rfaE bifunctional protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. (165 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (364 aa)
Desaf_2296KEGG: dba:Dbac_3297 hypothetical protein. (308 aa)
Desaf_2507KEGG: dsa:Desal_0976 hydrolase, HAD-superfamily, subfamily IIIA; TIGRFAM: Histidinol-phosphate phosphatase; HAD-superfamily hydrolase, subfamily IIIA; PFAM: Haloacid dehalogenase-like hydrolase. (177 aa)
Desaf_2590PFAM: Protein of unknown function DUF2219; KEGG: dap:Dacet_1626 hypothetical protein. (342 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (348 aa)
lpxAAcyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (271 aa)
Desaf_3022PFAM: Protein of unknown function DUF374; KEGG: dde:Dde_1961 hypothetical protein. (223 aa)
Desaf_3023PFAM: Bacterial lipid A biosynthesis acyltransferase; KEGG: dde:Dde_1962 acyltransferase. (304 aa)
Desaf_3173KEGG: dsa:Desal_2259 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; TIGRFAM: Phosphatase KdsC; HAD-superfamily hydrolase, subfamily IIIA. (173 aa)
Desaf_3253PFAM: Glycosyl transferase, family 9; KEGG: dvl:Dvul_1939 glycosyl transferase family protein. (355 aa)
Desaf_3659PFAM: Lipid A 3-O-deacylase-related; KEGG: lipid A 3-O-deacylase-like protein. (213 aa)
Your Current Organism:
Desulfocurvibacter africanus
NCBI taxonomy Id: 690850
Other names: D. africanus subsp. africanus str. Walvis Bay, Desulfocurvibacter africanus str. Walvis Bay, Desulfocurvibacter africanus subsp. africanus str. Walvis Bay, Desulfovibrio africanus ATCC 19997, Desulfovibrio africanus str. Walvis Bay, Desulfovibrio africanus strain Walvis Bay
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