(37 nodes) Mixed, incl. RHOU GTPase cycle, and Small GTPase Rho network (Gasterosteus aculeatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ARHGEF4	Rho guanine nucleotide exchange factor 4. (569 aa)
	G3NDH7_GASAC	Ras homolog family member Q. (141 aa)
	G3NEN7_GASAC	Rho guanine nucleotide exchange factor (GEF) 7a. (802 aa)
	G3NF67_GASAC	Cytoplasmic protein. (395 aa)
	G3NF92_GASAC	Spermatogenesis associated 13. (630 aa)
	G3NHC0_GASAC	Cytoplasmic protein. (383 aa)
	G3NLA9_GASAC	Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1. (1605 aa)
	G3NNV4_GASAC	Zgc:113162. (315 aa)
	G3NT06_GASAC	Non-specific serine/threonine protein kinase. (673 aa)
	G3P0N1_GASAC	Kalirin RhoGEF kinase a. (2926 aa)
	G3P341_GASAC	G protein-coupled receptor kinase interacting ArfGAP 2a. (760 aa)
	G3P4W6_GASAC	Ras homolog family member Ub. (243 aa)
	G3P609_GASAC	Thyroid hormone receptor interactor 10a. (586 aa)
	G3P6U5_GASAC	Uncharacterized protein. (191 aa)
	G3P8G4_GASAC	Uncharacterized protein. (2336 aa)
	PAK2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (498 aa)
	G3PA20_GASAC	Uncharacterized protein. (191 aa)
	G3PAN1_GASAC	Non-specific serine/threonine protein kinase. (539 aa)
	G3PFB8_GASAC	Non-specific serine/threonine protein kinase. (438 aa)
	CDC42	Cell division cycle 42. (197 aa)
	G3PG48_GASAC	P21 protein (Cdc42/Rac)-activated kinase 7. (637 aa)
	G3PHT1_GASAC	Ras homolog family member V. (236 aa)
	G3PIU6_GASAC	Non-specific serine/threonine protein kinase. (563 aa)
	G3PKI0_GASAC	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1691 aa)
	G3PKT1_GASAC	Non-specific serine/threonine protein kinase. (622 aa)
	G3PPS0_GASAC	Rho guanine nucleotide exchange factor (GEF) 7b. (800 aa)
	G3PQ06_GASAC	Rho family GTPase 3a. (243 aa)
	G3PRQ9_GASAC	Rac family small GTPase 3b. (192 aa)
	RHOU	Ras homolog family member U. (258 aa)
	G3PUS8_GASAC	Ras homolog family member H. (195 aa)
	G3PV93_GASAC	SH3 and PX domains 2Aa. (1116 aa)
	G3PW85_GASAC	Thyroid hormone receptor interactor 10b. (532 aa)
	G3PXX3_GASAC	Myosin IXAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2599 aa)
	G3PYU4_GASAC	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. (761 aa)
	G3Q3P7_GASAC	Uncharacterized protein. (459 aa)
	G3Q4B9_GASAC	Uncharacterized protein. (193 aa)
	PAK3	Non-specific serine/threonine protein kinase. (578 aa)

Your Current Organism:

Gasterosteus aculeatus

NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF4	CDC42	ENSGACP00000000134	ENSGACP00000016487	Rho guanine nucleotide exchange factor 4.	Cell division cycle 42.	0.842
ARHGEF4	G3NDH7_GASAC	ENSGACP00000000134	ENSGACP00000003377	Rho guanine nucleotide exchange factor 4.	Ras homolog family member Q.	0.771
ARHGEF4	G3NEN7_GASAC	ENSGACP00000000134	ENSGACP00000003788	Rho guanine nucleotide exchange factor 4.	Rho guanine nucleotide exchange factor (GEF) 7a.	0.404
ARHGEF4	G3NF92_GASAC	ENSGACP00000000134	ENSGACP00000003994	Rho guanine nucleotide exchange factor 4.	Spermatogenesis associated 13.	0.843
ARHGEF4	G3NNV4_GASAC	ENSGACP00000000134	ENSGACP00000007018	Rho guanine nucleotide exchange factor 4.	Zgc:113162.	0.451
ARHGEF4	G3NT06_GASAC	ENSGACP00000000134	ENSGACP00000008474	Rho guanine nucleotide exchange factor 4.	Non-specific serine/threonine protein kinase.	0.699
ARHGEF4	G3P4W6_GASAC	ENSGACP00000000134	ENSGACP00000012639	Rho guanine nucleotide exchange factor 4.	Ras homolog family member Ub.	0.776
ARHGEF4	G3P6U5_GASAC	ENSGACP00000000134	ENSGACP00000013319	Rho guanine nucleotide exchange factor 4.	Uncharacterized protein.	0.805
ARHGEF4	G3PA20_GASAC	ENSGACP00000000134	ENSGACP00000014444	Rho guanine nucleotide exchange factor 4.	Uncharacterized protein.	0.842
ARHGEF4	G3PAN1_GASAC	ENSGACP00000000134	ENSGACP00000014655	Rho guanine nucleotide exchange factor 4.	Non-specific serine/threonine protein kinase.	0.645
ARHGEF4	G3PFB8_GASAC	ENSGACP00000000134	ENSGACP00000016292	Rho guanine nucleotide exchange factor 4.	Non-specific serine/threonine protein kinase.	0.645
ARHGEF4	G3PG48_GASAC	ENSGACP00000000134	ENSGACP00000016572	Rho guanine nucleotide exchange factor 4.	P21 protein (Cdc42/Rac)-activated kinase 7.	0.645
ARHGEF4	G3PHT1_GASAC	ENSGACP00000000134	ENSGACP00000017157	Rho guanine nucleotide exchange factor 4.	Ras homolog family member V.	0.776
ARHGEF4	G3PIU6_GASAC	ENSGACP00000000134	ENSGACP00000017525	Rho guanine nucleotide exchange factor 4.	Non-specific serine/threonine protein kinase.	0.647
ARHGEF4	G3PKT1_GASAC	ENSGACP00000000134	ENSGACP00000018211	Rho guanine nucleotide exchange factor 4.	Non-specific serine/threonine protein kinase.	0.645
ARHGEF4	G3PPS0_GASAC	ENSGACP00000000134	ENSGACP00000019605	Rho guanine nucleotide exchange factor 4.	Rho guanine nucleotide exchange factor (GEF) 7b.	0.404
ARHGEF4	G3PQ06_GASAC	ENSGACP00000000134	ENSGACP00000019691	Rho guanine nucleotide exchange factor 4.	Rho family GTPase 3a.	0.602
ARHGEF4	G3PRQ9_GASAC	ENSGACP00000000134	ENSGACP00000020295	Rho guanine nucleotide exchange factor 4.	Rac family small GTPase 3b.	0.824
ARHGEF4	G3PUS8_GASAC	ENSGACP00000000134	ENSGACP00000021365	Rho guanine nucleotide exchange factor 4.	Ras homolog family member H.	0.771
ARHGEF4	G3PV93_GASAC	ENSGACP00000000134	ENSGACP00000021530	Rho guanine nucleotide exchange factor 4.	SH3 and PX domains 2Aa.	0.752