86 items (Gasterosteus aculeatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	G3N4C9_GASAC	Cubilin (intrinsic factor-cobalamin receptor). (3607 aa)
	G3N4P3_GASAC	DUF1943 domain-containing protein. (96 aa)
	G3N656_GASAC	LIM zinc-binding domain-containing protein. (739 aa)
	G3N6J1_GASAC	Uncharacterized protein. (230 aa)
	G3N717_GASAC	Uncharacterized protein; Belongs to the CD36 family. (439 aa)
	G3N889_GASAC	Non-specific serine/threonine protein kinase. (552 aa)
	G3N8K5_GASAC	3-hydroxy-3-methylglutaryl coenzyme A reductase. (887 aa)
	G3N9G6_GASAC	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (239 aa)
	G3N9X2_GASAC	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (420 aa)
	G3NAN3_GASAC	Isopentenyl-diphosphate delta isomerase 1. (259 aa)
	G3NCG9_GASAC	START domain-containing protein. (210 aa)
	G3NCV4_GASAC	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (500 aa)
	G3NCX8_GASAC	Apolipoprotein Ea. (286 aa)
	G3NCY8_GASAC	Lipase, hormone-sensitive a. (703 aa)
	G3NDL3_GASAC	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (735 aa)
	G3NFD0_GASAC	Phosphomevalonate kinase. (192 aa)
	G3NFI3_GASAC	Membrane-bound transcription factor peptidase, site 1. (1019 aa)
	G3NFX1_GASAC	Lipase, hormone-sensitive b. (775 aa)
	G3NFZ0_GASAC	Lecithin-cholesterol acyltransferase. (423 aa)
	G3NGM5_GASAC	Uncharacterized protein. (256 aa)
	G3NGN5_GASAC	Uncharacterized protein. (267 aa)
	G3NGQ8_GASAC	Apolipoprotein Eb. (264 aa)
	G3NHA3_GASAC	LIM zinc-binding domain-containing protein. (94 aa)
	G3NIC8_GASAC	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (251 aa)
	G3NJ66_GASAC	Lamin B receptor. (616 aa)
	G3NJG1_GASAC	Cytochrome P450, family 51; Belongs to the cytochrome P450 family. (496 aa)
	G3NLD8_GASAC	High density lipoprotein binding protein a. (1271 aa)
	G3NLK7_GASAC	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (517 aa)
	G3NLR2_GASAC	Squalene epoxidase a. (571 aa)
	G3NPF9_GASAC	Cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 4. (513 aa)
	G3NPH4_GASAC	Membrane-bound transcription factor peptidase, site 2. (446 aa)
	G3NRQ2_GASAC	Apolipoprotein A-Ib. (263 aa)
	G3NU58_GASAC	Low density lipoprotein receptor a. (875 aa)
	G3NUA6_GASAC	ER lipid raft associated 1. (314 aa)
	G3NUD9_GASAC	CLN8 transmembrane ER and ERGIC protein. (282 aa)
	G3NUN6_GASAC	Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor. (857 aa)
	G3NUS4_GASAC	ARV1 homolog, fatty acid homeostasis modulator. (247 aa)
	G3NV04_GASAC	Angiopoietin-like 3. (471 aa)
	G3NW15_GASAC	Uncharacterized protein. (868 aa)
	G3NW97_GASAC	Sterol regulatory element binding transcription factor 2. (1101 aa)
	G3NWU5_GASAC	Low density lipoprotein receptor adaptor protein 1b. (297 aa)
	G3NY15_GASAC	Niemann-Pick disease, type C2. (152 aa)
	G3P320_GASAC	Low density lipoprotein receptor adaptor protein 1a. (276 aa)
	G3P3B0_GASAC	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (397 aa)
	G3P546_GASAC	Apolipoprotein Bb, tandem duplicate 2. (3689 aa)
	G3P559_GASAC	EBP cholestenol delta-isomerase. (227 aa)
	G3P570_GASAC	Vitellogenin domain-containing protein. (1648 aa)
	G3P573_GASAC	Uncharacterized protein. (445 aa)
	G3P7J4_GASAC	Farnesyl-diphosphate farnesyltransferase 1. (416 aa)
	G3P7W5_GASAC	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (245 aa)
	G3P886_GASAC	Cholesterol 25-hydroxylase like 1, tandem duplicate 1; Belongs to the sterol desaturase family. (273 aa)
	G3P956_GASAC	LIM domain and actin binding 1a. (637 aa)
	DISP3	Dispatched RND transporter family member 3. (770 aa)
	G3PAV7_GASAC	24-dehydrocholesterol reductase. (517 aa)
	G3PCU5_GASAC	Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (543 aa)
	G3PDB8_GASAC	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (286 aa)
	NPC1L1	NPC1 like intracellular cholesterol transporter 1. (1287 aa)
	G3PDK2_GASAC	Glucosylceramidase. (539 aa)
	G3PDQ2_GASAC	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (387 aa)
	G3PEE2_GASAC	Sterol regulatory element binding transcription factor 1. (1164 aa)
	G3PGG5_GASAC	SREBF chaperone. (1277 aa)
	G3PIX9_GASAC	Cholesterol 25-hydroxylase like 3. (332 aa)
	G3PL65_GASAC	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (280 aa)
	G3PMK9_GASAC	7-dehydrocholesterol reductase. (472 aa)
	G3PNN1_GASAC	Cytochrome P450, family 7, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (488 aa)
	G3PT43_GASAC	3-hydroxy-3-methylglutaryl coenzyme A reductase. (872 aa)
	G3PT58_GASAC	Cholesterol 25-hydroxylase like 2; Belongs to the sterol desaturase family. (275 aa)
	G3PTT2_GASAC	Non-specific serine/threonine protein kinase. (582 aa)
	G3PTV2_GASAC	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (397 aa)
	G3PUL2_GASAC	Hydroxysteroid (17-beta) dehydrogenase 7. (339 aa)
	LRP8	LDL receptor related protein 8. (922 aa)
	ANGPTL3	Angiopoietin like 3. (480 aa)
	G3PX65_GASAC	CUB domain containing protein 2. (269 aa)
	G3PXR6_GASAC	CLN6 transmembrane ER protein a. (312 aa)
	G3PZ00_GASAC	Niemann-Pick disease, type C1. (1264 aa)
	G3Q188_GASAC	Very low density lipoprotein receptor. (844 aa)
	G3Q253_GASAC	Zgc:92275. (364 aa)
	G3Q2R9_GASAC	NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (344 aa)
	G3Q3W0_GASAC	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (515 aa)
	G3Q5U9_GASAC	Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (855 aa)
	G3Q6S7_GASAC	High density lipoprotein binding protein b. (1261 aa)
	G3Q7B2_GASAC	Low density lipoprotein receptor b. (832 aa)
	G3Q9N6_GASAC	DUF1943 domain-containing protein. (96 aa)
	G3QA83_GASAC	Transmembrane 7 superfamily member 2. (446 aa)
	G3QBG9_GASAC	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (584 aa)
	G3QC52_GASAC	Sterol-C5-desaturase; Belongs to the sterol desaturase family. (297 aa)

Your Current Organism:

Gasterosteus aculeatus

NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPTL3	G3PNN1_GASAC	ENSGACP00000021392	ENSGACP00000019214	Angiopoietin like 3.	Cytochrome P450, family 7, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family.	0.514
ANGPTL3	G3PXR6_GASAC	ENSGACP00000021392	ENSGACP00000022405	Angiopoietin like 3.	CLN6 transmembrane ER protein a.	0.414
ANGPTL3	NPC1L1	ENSGACP00000021392	ENSGACP00000015640	Angiopoietin like 3.	NPC1 like intracellular cholesterol transporter 1.	0.411
G3N4C9_GASAC	G3NGM5_GASAC	ENSGACP00000000149	ENSGACP00000004481	Cubilin (intrinsic factor-cobalamin receptor).	Uncharacterized protein.	0.507
G3N4C9_GASAC	G3NGN5_GASAC	ENSGACP00000000149	ENSGACP00000004491	Cubilin (intrinsic factor-cobalamin receptor).	Uncharacterized protein.	0.506
G3N4C9_GASAC	G3NRQ2_GASAC	ENSGACP00000000149	ENSGACP00000008005	Cubilin (intrinsic factor-cobalamin receptor).	Apolipoprotein A-Ib.	0.437
G3N4C9_GASAC	G3NWU5_GASAC	ENSGACP00000000149	ENSGACP00000009814	Cubilin (intrinsic factor-cobalamin receptor).	Low density lipoprotein receptor adaptor protein 1b.	0.402
G3N4P3_GASAC	G3N6J1_GASAC	ENSGACP00000000263	ENSGACP00000000916	DUF1943 domain-containing protein.	Uncharacterized protein.	0.728
G3N4P3_GASAC	G3N717_GASAC	ENSGACP00000000263	ENSGACP00000001092	DUF1943 domain-containing protein.	Uncharacterized protein; Belongs to the CD36 family.	0.785
G3N4P3_GASAC	G3NCV4_GASAC	ENSGACP00000000263	ENSGACP00000003154	DUF1943 domain-containing protein.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.736
G3N4P3_GASAC	G3NCX8_GASAC	ENSGACP00000000263	ENSGACP00000003178	DUF1943 domain-containing protein.	Apolipoprotein Ea.	0.801
G3N4P3_GASAC	G3NGM5_GASAC	ENSGACP00000000263	ENSGACP00000004481	DUF1943 domain-containing protein.	Uncharacterized protein.	0.865
G3N4P3_GASAC	G3NGN5_GASAC	ENSGACP00000000263	ENSGACP00000004491	DUF1943 domain-containing protein.	Uncharacterized protein.	0.865
G3N4P3_GASAC	G3NGQ8_GASAC	ENSGACP00000000263	ENSGACP00000004514	DUF1943 domain-containing protein.	Apolipoprotein Eb.	0.781
G3N4P3_GASAC	G3NRQ2_GASAC	ENSGACP00000000263	ENSGACP00000008005	DUF1943 domain-containing protein.	Apolipoprotein A-Ib.	0.859
G3N4P3_GASAC	G3NU58_GASAC	ENSGACP00000000263	ENSGACP00000008876	DUF1943 domain-containing protein.	Low density lipoprotein receptor a.	0.647
G3N4P3_GASAC	G3NUN6_GASAC	ENSGACP00000000263	ENSGACP00000009055	DUF1943 domain-containing protein.	Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor.	0.646
G3N4P3_GASAC	G3NWU5_GASAC	ENSGACP00000000263	ENSGACP00000009814	DUF1943 domain-containing protein.	Low density lipoprotein receptor adaptor protein 1b.	0.703
G3N4P3_GASAC	G3NY15_GASAC	ENSGACP00000000263	ENSGACP00000010235	DUF1943 domain-containing protein.	Niemann-Pick disease, type C2.	0.617
G3N4P3_GASAC	G3P320_GASAC	ENSGACP00000000263	ENSGACP00000011993	DUF1943 domain-containing protein.	Low density lipoprotein receptor adaptor protein 1a.	0.583